European Guidelines for Quality Assurance in Cervical Cancer Screening have been initiated the Europe Against Programme. The first edition established principles of organised population-based screening and stimulated numerous pilot projects. second multidisciplinary was published 2008 comprises approximately 250 pages divided into seven chapters prepared by 48 authors contributors. Considerable attention has devoted to organised, programme policies which minimise adverse effects maximise...

The cervical smear test, like all screening tests, is not 100% effective in detecting abnormality. In order to prevent 80-90% of invasive cancers, requires smears be taken competently at regular intervals and correctly interpreted. With laboratories following the guidelines this report, NHSCSP should able meet Health Nation target reduce incidence cancer less than 12 cases per 100 000 women UK by year 2000.

The current paper presents an annex in the second edition of European Guidelines for Quality Assurance Cervical Cancer Screening. It provides guidance on how to make a satisfactory conventional Pap smear or liquid‐based cytology (LBC) sample. Practitioners taking samples should first explain woman purpose, procedure and result will be communicated. Three sampling methods are considered as acceptable preparing smears: (i) cervical broom; (ii) combination spatula endocervical brush; (iii)...

EGFR mutations correlate with improved clinical outcome whereas KRAS are associated lack of response to tyrosine kinase inhibitors in patients non-small cell lung cancer (NSCLC). Endobronchial ultrasound (EBUS)-transbronchial needle aspiration (TBNA) is being increasingly used the management NSCLC. Co-amplification at lower denaturation temperature (COLD)–polymerase chain reaction (PCR) (COLD-PCR) a sensitive assay for detection genetic solid tumours. This study assessed feasibility using...

Antibodies raised against human milk fat globule (HMFG 1 and 2) carcinoembryonic antigen were used in an immunoperoxidase technique to differentiate mesothelioma, carcinoma, benign, reactive mesothelium. Sixteen mesotheliomas, 27 lung carcinomas, 13 specimens of mesothelium examined. Staining for was not seen or mesothelioma but present 22 carcinomas. Mesothelioma carcinoma usually stained with HMFG 2; did not. These three antibodies may help distinguish

There are many different systems of cytology classification used in the member states European Union (EU) and languages. The following short annexe to Chapter 3 Guidelines for Quality Assurance Cervical Cancer Screening provides a framework that will allow terminologies languages be translated into standard terminology based on Bethesda system (TBS) while retaining cervical intraepithelial neoplasia (CIN) histology. This approach has followed extensive consultation with representatives...

The BSCC terminology was originally published in 1986 and although highly successful, requires revision. Through a process of professional consensus literature review this has been undertaken by the BSCC. revision takes account recent developments improvements understanding morphology disease is compatible with other terminologies use elsewhere, whilst still maintaining focus on practice UK cervical screening programmes.

Histological diagnosis of malignant mesothelioma and differentiation from adenocarcinoma is often difficult. Definitive pathological confirmation requires demonstration an appropriate immunohistochemical phenotype. Selection optimum panel antibodies for the reliable identification hindered by absence a specific label cells. Recently, we have found that ovarian carcinoma cell antibody CA125 labels cells, HBME-1 has been developed as sensitive mesothelial marker. We compared staining patterns...

Objectives: Endoscopic ultrasound (EUS)‐guided fine needle aspiration (FNA) is increasingly used in preoperative localization and diagnosis of pancreatic neoplasms including neuroendocrine tumours (NETs). The objective the present study was to identify cytological features NETs obtained by EUS‐FNA. Methods: group consisted nine cases correctly diagnosed or strongly suggestive based on Cytological smears were retrospectively reviewed. clinical data immunocytochemical stains applied cell block...

The quality of a cervical cytology laboratory depends on adequate handling and staining the samples, screening interpretation slides reporting results. These guidelines give an overview procedures recommended in Europe to manage balance between best patient care possible, assurance cost effectiveness will be published as chapter 4 European Guidelines for Quality Assurance Cervical Cancer Screening. include protocols personnel organisation, material requirements, analysing recording results,...

Abstract In women over the age of 35 years, an accurate diagnosis breast cancer can be made in 95 per cent patients using a ‘triple assessment’ system collating information from clinical examination, mammography, sonomammography, and fine-needle aspiration cytology. These methods have not been specifically evaluated aged years or less, hence study was undertaken on 30 such patients. Clinical examination unreliable predicting malignancy with sensitivity only 37 cent. Thirty presented lump...

Abstract The widespread interstitial pulmonary infiltration in two patients, showing the clinical, radiological and histological features of lymphocytic pneumonia (LIP), has been characterized by immunological criteria as malignant lymphoma follicle centre cell (FCC) origin with plasmacytic differentiation. One patient also had parotid glands which present for many years was previously considered benign (benign lymphoepithelial lesion). other a long history Sjögrens syndrome. lymphomas these...

In an attempt to distinguish reactive from neoplastic mesothelial proliferation, the histological material and clinical records of 153 patients on whom open or closed pleural biopsies were performed during 1976 reviewed. six 10 subsequently shown have malignant mesothelioma specimens biopsy had been reported as negative equivocal but in retrospect showed changes not observed pleurisy. These included papillary exfoliated papillae, sheets atypical cells, abnormal fibroblastic proliferation....

Three patients, two with typical primary Sjögren's syndrome (SS) and the third several features of SS, including abnormal sialography reduced tear secretion, developed B cell non-Hodgkin's lymphoma (NHL) parotid or lung, both. Isoelectric focusing concentrated urine specimens in agarose, followed by immunofixation, demonstrated presence each patient's monoclonal free light chains same class as that shown on tumour cells. In one patient level urinary was monitored found to correlate disease...

Despite the high response rates induced by chemotherapy, many patients with limited small-cell lung cancer (SCLC) relapse at site of primary disease. Failure radiotherapy to overcome this has led use surgery as part a combined modality approach. Between December 1981 and 1985, 189 SCLC were assessed for suitability after an initial three cycles chemotherapy (doxorubicin, cyclophosphamide, etoposide). Fifty-seven found have disease, these, 19 ineligible or unfit surgery. Of 38 eligible...