A5045651407- Occupational and environmental lung diseases
- Occupational exposure and asthma
- Air Quality and Health Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lanthanide and Transition Metal Complexes
- Medical Imaging and Pathology Studies
- Advanced MRI Techniques and Applications
- Inhalation and Respiratory Drug Delivery
- Pleural and Pulmonary Diseases
- Neonatal Respiratory Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Radiation Dose and Imaging
- Orthopaedic implants and arthroplasty
- Traumatic Ocular and Foreign Body Injuries
- Breast Implant and Reconstruction
- Noise Effects and Management
- Parathyroid Disorders and Treatments
- Cerebral Venous Sinus Thrombosis
- Indoor Air Quality and Microbial Exposure
- Occupational Health and Safety Research
- Medical Imaging Techniques and Applications
- Radioactivity and Radon Measurements
- Luminescence Properties of Advanced Materials
- Electron and X-Ray Spectroscopy Techniques
- MRI in cancer diagnosis
SUNY Upstate Medical University
2015-2024
New England Research (United States)
2014
New England Research Institutes
2014
Centers for Medicare and Medicaid Services
2014
Office of Science
2014
Memorial Sloan Kettering Cancer Center
2011
New York Hospital Queens
2011
NewYork–Presbyterian Hospital
2011
American Red Cross
2011
Bellevue Hospital Center
2011
Fluconazole has been associated with various teratisms in animals, including craniofacial ossification defects, thin, wavy ribs, and renal pelvis defects. We describe three infants born to women who were receiving fluconazole through or beyond the first trimester of pregnancy. All had congenital anomalies; no other drug was implicated. Only one survived. Their anomalies, similar those observed animal studies, largely craniofacial, skeletal (i.e., ribs defects), cardiac. One these previously...
Gadolinium (Gd)-based magnetic resonance contrast agents (GBMCA), including gadodiamide, have been identified as the probable causative of serious disease, nephrogenic systemic fibrosis (NSF).To investigate retained Gd-containing deposits in skin biopsies from patients with NSF and to determine their relative concentrations over time administration GBMCA.An investigator-blinded retrospective study, analysing 43 20 gadodiamide-related one NSF-negative gadodiamide-exposed dialysis patient,...
Abstract Nephrogenic systemic fibrosis (NSF) is a painful and debilitating fibrosing disorder of the skin tissues. It associated with exposure to Gd, used in MRIs MRAs, patients renal insufficiency. We here present an illustrative example young patient who underwent multiple Gd‐enhanced scans, both before after developing severe NSF. examined biopsy tissues for quantification detectable insoluble Gd deposits using automated scanning electron microscopy/energy dispersive X‐ray spectroscopy....
Rationale: Recent reports of progressive massive fibrosis and rapidly pneumoconiosis in U.S. coal miners have raised concerns about excessive exposures to mine dust, despite declining dust levels.Objectives: To evaluate the histologic abnormalities retained particles available miner lung pathology specimens, compare these findings with those derived from corresponding chest radiographs.Methods: Miners severe disease tissue were identified through investigator outreach. Demographic as well...
Fibrous tissue capsules, from around silicone breast implants, were examined by light microscopy, and transmission scanning electron the latter combined with energy dispersive X-ray analysis. Contractile fibroblasts (myofibroblasts) found in most of these fibrous especially those recently formed or manipulated. The element silicon was positively identified analysis half specimens. This material only gel-filled implants. In specimens studied, clinical hardness unrelated to presence capsule.
Rationale: The reasons for resurgent coal workers’ pneumoconiosis and its most severe forms, rapidly progressive massive fibrosis (PMF), in the United States are not yet fully understood. Objectives: To compare pathologic mineralogic features of contemporary miners with those their historical counterparts. Methods: Lung pathology specimens from 85 PMF were included evaluation analysis. We compared proportion cases findings born between 1910 1930 (historical) or after (contemporary). Results:...
Exposure to atmospheric fine particulate matter (PM), even at low ambient concentrations, has clearly been linked increases in mortality and morbidity. A 10- micro g m(-3) increase PM10 (PM < 10 m) found produce a 0.5% daily mortality. The mechanism of action is source debate, although recent attention focused on the cardiac effects PM exposures. Likewise, several possible etiologic agents have implicated, including ultrafine <or= 100 nm), metals, acid components, yet responsible constituent...
A patient presented with granulomatous lung disease associated the pulmonary deposition of various metallic particles. To evaluate relation between dust and process, lymphocyte transformation tests to aluminium sulphate, titanium chloride, beryllium nickel sulphate were performed. proliferative response chloride was observed on two separate occasions; no responses other metals shown. These results are consistent hypersensitivity titanium, suggest, in this individual, a possible aetiological...
Epidemiologic surveys have indicated an excess of nonmalignant respiratory disease in workers exposed to aluminum oxide (Al2O3) during abrasives production. However, clinical, roentgenographic, histologic, and microanalytic description these are lacking.This is a report nine Al2O3-exposed with abnormal chest roentgenograms (profusion ⩾ 1/0, ILO/UC) from plant engaged the production Al2O3 alundum ore. Mean duration exposure was 25 yr, time since first 28 yr. In subgroup three, severity...
Nephrogenic systemic fibrosis (NSF) is an extremely debilitating fibrosing disorder affecting renal failure patients. The association of NSF with gadolinium (Gd) containing magnetic resonance contrast agents was noted in 2006. Gd deposition skin biopsies demonstrated shortly thereafter.We used automated scanning electron microscopy (SEM)/energy dispersive x-ray spectroscopy for situ quantitative analysis insoluble Gd-containing deposits, recording multi-elemental composition and spatial...
Objective: To describe pathologic findings in symptomatic World Trade Center–exposed local workers, residents, and cleanup workers enrolled a treatment program. Methods: Twelve patients underwent surgical lung biopsy for suspected interstitial disease (group 1, n = 6) or abnormal pulmonary function tests 2, 6). High-resolution computed axial tomography were coded. Scanning electron microscopy with energy-dispersive x-ray spectroscopy was performed. Results: showed reticular 1) normal...