A5040752700- Cervical Cancer and HPV Research
- Genital Health and Disease
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Reproductive tract infections research
- Social Issues in Poland
- Healthcare Policy and Management
- Bladder and Urothelial Cancer Treatments
- Healthcare Systems and Technology
- Lymphatic System and Diseases
- Peripheral Artery Disease Management
- Patient-Provider Communication in Healthcare
- Primary Care and Health Outcomes
- Foot and Ankle Surgery
- Statistical Methods in Clinical Trials
- Polish socio-economic development
- Social Media in Health Education
- Global Health Workforce Issues
- Hepatitis B Virus Studies
- Medical Research and Treatments
University of Oxford
2016-2024
University of Manchester
2007-2009
Human papillomavirus (HPV) infection causes cervical cancer and premalignant dysplasia. Type-specific HPV prevalence data provide a basis for assessing the impact of vaccination programmes on cytology. We report high-risk (HR-HPV) type-specific in relation to cytology 24 510 women (age range: 20–64; mean age 40.2 years) recruited into ARTISTIC trial, which is being conducted within routine NHS Cervical Screening Programme Greater Manchester. The most common HR-HPV types were HPV16, 18, 31,...
Prostate cancer (PCa) is the most common in men UK. Patients with intermediate-risk, clinically localised disease are offered radical treatments such as surgery or radiotherapy, which can result severe side effects. A number of alternative partial ablation (PA) technologies that may reduce treatment burden available; however comparative effectiveness these techniques has never been evaluated a randomised controlled trial (RCT).To assess feasibility RCT PA using high-intensity focused...
Abstract Purpose Prostate-specific membrane antigen (PSMA) is increasingly used to image prostate cancer in clinical practice. We sought develop and test a humanised PSMA minibody IAB2M conjugated the fluorophore IRDye 800CW-NHS ester men undergoing robot-assisted laparoscopic radical prostatectomy (RARP) cells during surgery. Methods The was evaluated pre-clinically using positive/negative xenograft models, following which 23 RARP between 2018 2020 received 2.5 mg 20 of IR800-IAB2M...
We present data on the use of Hybrid Capture 2 (HC2) test for detection high-risk human papillomavirus (HR HPV) with different thresholds positivity within a primary screening setting and as method triage low-grade cytology. In ARTISTIC population-based trial, 18,386 women were screened by cytology HPV. Cervical intraepithelial neoplasia lesions grade two higher (CIN2+ lesions) identified 453 30 months an abnormal baseline sample. When relative light unit/cutoff (RLU/Co) ratio > or = 1 was...
Total ankle replacement (TAR) or arthrodesis (fusion) is the main surgical treatments for end-stage osteoarthritis (OA). The popularity of increasing while fusion rates remain static. Both have efficacy but to date all studies comparing 2 been observational without randomisation, and there are no published guidelines as most appropriate management. TAR versus (TARVA) trial aims compare clinical cost-effectiveness against in treatment OA patients aged 50-85 years.TARVA a multicentre...
Introduction: The ARTISTIC trial was set up within the NHS Cervical Screening Programme in Greater Manchester to evaluate effectiveness of human papillomavirus (HPV) testing primary cervical screening. Here we present preliminary final results. Methods: 24 510 women aged 25–64 were enrolled study after consenting be tested for high‐risk infection (HR–HPV) addition liquid‐based cytology. Participants randomised HPV revealed or concealed results arms a 3:1 ratio. carried out using Hybrid...