A5061256858- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Musculoskeletal synovial abnormalities and treatments
- Prostate Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Bone and Joint Diseases
- Spinal Fractures and Fixation Techniques
- Osteomyelitis and Bone Disorders Research
- Cancer, Lipids, and Metabolism
- Oral and Maxillofacial Pathology
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Management of metastatic bone disease
- Dermatological and Skeletal Disorders
- Bone health and treatments
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Orthopaedic implants and arthroplasty
- Advanced Radiotherapy Techniques
- Scoliosis diagnosis and treatment
- Multisensory perception and integration
- Vascular Tumors and Angiosarcomas
University Hospitals Birmingham NHS Foundation Trust
2008-2022
University of Birmingham
2013-2019
NIHR Surgical Reconstruction and Microbiology Research Centre
2015-2019
Royal Orthopaedic Hospital
2009-2017
European Society of Radiology
2016
Aston University
2016
Royal National Orthopaedic Hospital NHS Trust
2012-2013
University College London
2012-2013
Selly Oak Hospital
2010
Heart of England NHS Foundation Trust
2010
BackgroundBased on previous findings, we hypothesised that radiotherapy to the prostate would improve overall survival in men with metastatic cancer, and benefit be greatest patients a low burden. We aimed compare standard of care for without radiotherapy.MethodsWe did randomised controlled phase 3 trial at 117 hospitals Switzerland UK. Eligible had newly diagnosed cancer. randomly allocated open-label 1:1 ratio (control group) or (radiotherapy group). Randomisation was stratified by...
BackgroundSTAMPEDE has previously reported that the use of upfront docetaxel improved overall survival (OS) for metastatic hormone naïve prostate cancer patients starting long-term androgen deprivation therapy. We report on outcomes stratified by burden M1 patients.MethodsWe randomly allocated in 2 : 1 ratio to standard-of-care (SOC; control group) or SOC + docetaxel. Metastatic disease was categorised using retrospectively-collected baseline staging scans where available. Analysis used Cox...
Background STAMPEDE has previously reported that radiotherapy (RT) to the prostate improved overall survival (OS) for patients with newly diagnosed cancer low metastatic burden, but not those high-burden disease. In this final analysis, we report long-term findings on primary outcome measure of OS and secondary measures symptomatic local events, RT toxicity quality life (QoL). Methods Patients were randomised at care sites in United Kingdom Switzerland between January 2013 September 2016,...
BCOR-CCNB3 fusion transcripts resulting from an X-chromosomal paracentric inversion were recently identified in a series of unclassifiable soft tissue and bone sarcomas with Ewing sarcoma-like morphology. The morphologic clinical features these are, as yet, not well characterized. Here we describe the clinicopathologic 10 cases sarcoma compare their course typical sarcoma. Nine patients male, all 11 to 18 years age. Seven tumors located 3 deep tissues. histomorphologic spectrum was quite...
(1) To examine how many patients have clinically and/or radiologically active chronic recurrent multifocal osteomyelitis (CRMO) ≥ 10 years after first onset of symptoms, and (2) to compare clinical whole-body magnetic resonance imaging (WB-MRI) findings.Seventeen (82% women) who were diagnosed with childhood-onset CRMO at least (average 12) before reexamination reevaluated. Patients completed a standardized questionnaire, underwent laboratory investigation WB-MRI. Clinical features compared...
Prostate radiotherapy (RT) improves survival in men with low-burden metastatic prostate cancer. However, owing to the dichotomized nature of burden criteria, it is not clear how this benefit varies bone metastasis counts and site.
The aim of this study was to identify any progression between benign osteofibrous dysplasia (OFD), OFD-like adamantinoma and malignant adamantinoma, investigate the rates local recurrence, metastases survival, in order develop treatment algorithms for each.A single institution retrospective review all patients presenting with OFD, 1973 2012 undertaken. Complete data were available 73 (42 OFD; ten an 21 adamantinoma). mean follow-up 10.3 years (3 25) 9.2 (3.0 26.3) 11.6 (0.25 33)...
Aims Myoepithelial tumours of soft tissue are rare lesions with a broad morphological and clinical spectrum. Previous studies have found EWSR1 rearrangements in approximately half all cases PBX1 , ZNF44 POU5F1 been identified as recurrent fusion partners. In bone, only small number myoepithelial described. We investigated an intraosseous myoepithelioma the sacrum 54‐year‐old man without rearrangement for presence other genes. Methods results G‐banding analysis, SNP‐array fluorescence situ...
Abstract Purpose Postoperative infection still constitutes an important complication of spine surgery, and the optimal imaging modality for diagnosing postoperative has not yet been established. The aim this prospective multicenter study was to assess diagnostic performance three modalities in patients with suspected infection: MRI, [ 18 F]FDG PET/CT, SPECT/CT 99m Tc-UBI 29-41. Methods Patients had undergo at least 2 out 3 investigated. Sixty-three enrolled fulfilled such criteria were...