A5087986236- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Cancer, Lipids, and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Radiopharmaceutical Chemistry and Applications
- Urinary and Genital Oncology Studies
- Single-cell and spatial transcriptomics
- Molecular Biology Techniques and Applications
- PARP inhibition in cancer therapy
- Statistical Methods in Clinical Trials
- Cell Adhesion Molecules Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cell Image Analysis Techniques
- Urological Disorders and Treatments
- Immunotherapy and Immune Responses
- Gene expression and cancer classification
University of Manchester
2019-2025
The Christie NHS Foundation Trust
2019-2025
Cancer Research UK Manchester Institute
2019-2024
Lancashire Teaching Hospitals NHS Foundation Trust
2024
Prostate Cancer Research
2021
Manchester Academic Health Science Centre
2019
BackgroundSTAMPEDE has previously reported that the use of upfront docetaxel improved overall survival (OS) for metastatic hormone naïve prostate cancer patients starting long-term androgen deprivation therapy. We report on outcomes stratified by burden M1 patients.MethodsWe randomly allocated in 2 : 1 ratio to standard-of-care (SOC; control group) or SOC + docetaxel. Metastatic disease was categorised using retrospectively-collected baseline staging scans where available. Analysis used Cox...
Abstract Spatially resolved transcriptomics has enabled the study of expression genes within tissues while retaining their spatial identity. Most (ST) technologies generate a matched histopathological image as part standard pipeline, providing morphological information that can complement data. Here, we present CellPie, fast, unsupervised factor discovery method based on joint non-negative matrix factorization RNA transcripts and histological features. CellPie employs accelerated...
The emergence of castration-resistant prostate cancer remains an area unmet clinical need. We recently identified a subpopulation normal progenitor cells, characterized by intrinsic resistance to androgen deprivation and expression LY6D. here demonstrate that conditional deletion PTEN in the murine epithelium causes expansion transformed LY6D+ cells without impairing stem cell properties. Transcriptomic analyses luminal autocrine positive feedback loop, based on secretion amphiregulin...
Spatially resolved transcriptomics has enabled the study of expression genes within tissues while retaining their spatial identity. Most technologies generate a matched histopathological image as part standard pipeline, providing morphological information that can complement data. Here we present CellPie , fast, unsupervised factor discovery method, based on joint non-negative matrix factorisation RNA transcripts and histological features. employs accelerated hierarchical least squares...
The emergence of castration resistant prostate cancer is associated with a high mortality and remains an area unmet clinical need. We recently identified rare subpopulation normal progenitor cells, characterized by intrinsic resistance to androgen-deprivation marked the expression LY6D. here describe underlying mechanisms driving castration-resistance LY6D+ luminal progenitors their contribution advanced cancer. demonstrate that conditional deletion PTEN in murine epithelium causes expansion...