A5083507492- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Gut microbiota and health
- CRISPR and Genetic Engineering
- Coral and Marine Ecosystems Studies
- RNA and protein synthesis mechanisms
- Escherichia coli research studies
- Environmental DNA in Biodiversity Studies
- RNA Interference and Gene Delivery
- Evolution and Genetic Dynamics
- Virus-based gene therapy research
- Viral Infectious Diseases and Gene Expression in Insects
- Antibiotic Resistance in Bacteria
- Molecular Biology Techniques and Applications
- Wildlife Ecology and Conservation
- Prostate Cancer Treatment and Research
- Clostridium difficile and Clostridium perfringens research
- Prostate Cancer Diagnosis and Treatment
- Rangeland Management and Livestock Ecology
- Identification and Quantification in Food
- Mitochondrial Function and Pathology
- Animal Diversity and Health Studies
- Wireless Power Transfer Systems
Université Paris-Saclay
2020-2025
Centre National de la Recherche Scientifique
2014-2025
CEA Paris-Saclay
2021-2025
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2021-2025
Genoscope
2020-2025
Génomique Métabolique du Genoscope
2020-2023
Museum of Decorative Arts in Prague
2022
Université d'Évry Val-d'Essonne
2022
Manchester Academic Health Science Centre
2021
Health Sciences Centre
2021
The roles of restriction-modification (R-M) systems in providing immunity against horizontal gene transfer (HGT) and stabilizing mobile genetic elements (MGEs) have been much debated. However, few studies precisely addressed the distribution these light HGT, its mechanisms vectors. We analyzed R-M 2261 prokaryote genomes found their frequency to be strongly dependent on presence MGEs, CRISPR-Cas systems, integrons natural transformation. Yet are rare plasmids, prophages nearly absent from...
Bacterial adaptation is accelerated by the acquisition of novel traits through horizontal gene transfer, but integration these genes affects genome organization. We found that transferred are concentrated in only ~1% chromosomal regions (hotspots) 80 bacterial species. This concentration increases with size and rate transfer. Hotspots diversify rapid turnover; their distribution depends on local contexts (neighboring core genes), content mobile genetic elements. concentrate most changes...
Abstract Bacteria have developed various defense mechanisms to avoid infection and killing in response the fast evolution turnover of viruses other genetic parasites. Such pan-immune system ( defensome ) encompasses a growing number lines that include well-studied innate adaptive systems such as restriction-modification, CRISPR-Cas abortive infection, but also newly found ones whose are still poorly understood. While abundance distribution is well-known complete culturable genomes, there...
Significance The role of restriction–modification (R-M) as bacteria's innate immune system, and a barrier to sexual exchange, has often been challenged. Recent works suggested that the diversification these systems might have driven evolution highly virulent bacterial lineages. Here, we showed R-M were more abundant in species enduring DNA exchanges within-species flux genetic material was higher when cognate present. Presumably, bacteria frequent infections by mobile elements select for...
Coral reefs are among the most diverse ecosystems on Earth. They support high biodiversity of multicellular organisms that strongly rely associated microorganisms for health and nutrition. However, extent coral reef microbiome diversity its distribution at oceanic basin-scale remains to be explored. Here, we systematically sampled 3 morphotypes, 2 fish species, planktonic communities in 99 from 32 islands across Pacific Ocean, assess composition biogeography. We show a very large richness...
Self-transmissible mobile genetic elements drive horizontal gene transfer between prokaryotes. Some of these integrate in the chromosome, whereas others replicate autonomously as plasmids. Recent works showed existence few differences, and occasional interconversion, two types elements. Here, we enquired on why evolutionary processes have maintained by comparing integrative conjugative (ICE) with extrachromosomal ones (conjugative plasmids) highly abundant MPFT type. We observed that...
Abstract Coral reef science is a fast-growing field propelled by the need to better understand coral health and resilience devise strategies slow loss resulting from environmental stresses. Key are symbiotic interactions established within complex holobiont, i.e . multipartite assemblages comprising host organism, endosymbiotic dinoflagellates, bacteria, archaea, fungi, viruses. Tara Pacific an ambitious project built upon experience of previous Oceans expeditions, leveraging...
Abstract Pinctada radiata , commonly known as the Gulf pearl oyster, is a species of oyster found primarily in warm waters Red Sea, Persian Gulf, and parts Indian Ocean. contributes to marine ecosystems by filtering water, which helps maintain water quality supports other life. This first bivalve Lessepsian migrant, having migrated from Sea Mediterranean via Suez Canal. The reference genome could help identify genes enabling adaptation varying temperatures salinities, facilitating survival...
Abstract The reference genome of Androsace saussurei (Ericales: Primulaceae: Primuloideae) provides a valuable resource for understanding the mechanisms plant adaptations to most extreme environments where flowering plants can thrive and speciation dwelling on high alpine sky islands. entirety sequence was assembled into 20 contiguous chromosomal pseudomolecules. This chromosome-level assembly encompasses 413 Mb, composed 253 contigs 101 scaffolds, with contig scaffold N50 values 4.95 Mb...
Arca noae, also known as the Noah's Ark clam, is a bivalve mollusk found in shallow coastal waters of Mediterranean Sea and eastern Atlantic Ocean. This species plays crucial ecological role by filtering plankton organic particles from water, helping maintain water quality supporting nutrient cycling marine ecosystems. It an important food source for various predators, including fish crustaceans, thereby contributing to web. noae notably resilient environmental stressors, such temperature...
The Acomys minous reference genome offers a crucial resource for uncovering phylogenetic relationships within the genus and its complex phylogeographic history . entirety of sequence was assembled into 20 contiguous chromosomal pseudomolecules. This chromosome-level assembly encompasses 2.35 Gb, composed 297 contigs 113 scaffolds, with contig scaffold N50 values 29.3 Mb Mb, respectively.
Pinctada radiata , commonly known as the Gulf pearl oyster, is a species of oyster found primarily in warm waters Red Sea, Persian Gulf, and parts Indian Ocean. contributes to marine ecosystems by filtering water, which helps maintain water quality supports other life. This first bivalve Lessepsian migrant, having migrated from Sea Mediterranean via Suez Canal. The reference genome could help identify genes enabling adaptation varying temperatures salinities, facilitating survival diverse...
Arca noae , also known as the Noah's Ark clam, is a bivalve mollusk found in shallow coastal waters of Mediterranean Sea and eastern Atlantic Ocean. This species plays crucial ecological role by filtering plankton organic particles from water, helping maintain water quality supporting nutrient cycling marine ecosystems. It an important food source for various predators, including fish crustaceans, thereby contributing to web. notably resilient environmental stressors, such...
Mitochondrial DNA (mtDNA) deletion mutations are frequently observed in aged postmitotic tissues and the cause of a wide range human disorders. Presently, molecular bases underlying mtDNA formation remain matter intense debate, it is commonly accepted that several mechanisms contribute to spectra mitochondrial genome. In this work we performed an extensive screening deletions evaluated association between breakpoint density presence non-canonical elements over-represented sequence motifs....
Transposition in IS3, IS30, IS21 and IS256 insertion sequence (IS) families utilizes an unconventional two-step pathway. A figure-of-eight intermediate Step I, from asymmetric single-strand cleavage joining reactions, is converted into a double-stranded minicircle whose junction (the abutted left right ends) the substrate for symmetrical transesterification attacks on target DNA II, suggesting intrinsically different synaptic complexes (SC) each step. Transposases of these ISs bind poorly to...