A5039227106- Virus-based gene therapy research
- Cancer Research and Treatments
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- RNA Interference and Gene Delivery
- Esophageal and GI Pathology
- Brain Metastases and Treatment
- CAR-T cell therapy research
- Radiopharmaceutical Chemistry and Applications
- Viral gastroenteritis research and epidemiology
- Prostate Cancer Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- DNA Repair Mechanisms
- Neuroblastoma Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Biosimilars and Bioanalytical Methods
- Hormonal and reproductive studies
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
University of Hull
2022-2024
Castle Hill Hospital
2011-2023
St James's University Hospital
2009-2020
Leeds Teaching Hospitals NHS Trust
2018-2019
Scarborough General Hospital
2014-2019
Hull and East Yorkshire Hospitals NHS Trust
2012-2018
Moorfields Eye Hospital NHS Foundation Trust
2016
University College London
2016
Moorfields Eye Hospital
2016
Hull Royal Infirmary
2011
Abiraterone acetate plus prednisolone improves survival in men with relapsed prostate cancer. We assessed the effect of this combination starting long-term androgen-deprivation therapy (ADT), using a multigroup, multistage trial design.
Abstract Purpose: This study sought to define the recommended dose of JS1/34.5-/47-/GM-CSF, an oncolytic herpes simplex type-1 virus (HSV-1) encoding human granulocyte-macrophage colony-stimulating factor (GM-CSF), for future studies in combination with chemoradiotherapy patients squamous cell cancer head and neck (SCCHN). Experimental Design: Patients stage III/IVA/IVB SCCHN received (70 Gy/35 fractions concomitant cisplatin 100 mg/m2 on days 1, 22, 43) dose-escalating (106, 106, 106 pfu/mL...
<h3>Abstract</h3> The rigid, stimulus-bound nature of drug seeking that characterizes Substance-use disorder (SUD) has been related to a dysregulation motivational and early attentional reflexive inhibitory reflective systems. However, the mechanisms by which these systems are engaged drug-paired conditioned stimuli CSs) when they promote enactment habits in individuals with SUD have not elucidated. present study aimed behaviorally electrophysiologically characterize interaction between...
The Na/I symporter (hNIS) promotes concentration of iodine in cells. In cancer gene therapy, this transgene has potential as a reporter for molecular imaging viral biodistribution and therapeutic protein promoting (131)I-mediated radiotherapy. Here, we combined the hNIS an oncolytic adenoviruses targeting colorectal cells.We generated adenovirus (AdIP2) encoding capable selective replication carcinoma selectivity virus was verified vitro vivo. Its spread tumors monitored vivo using...
To assess the effects of external beam radiotherapy (EBRT) on adenoviral-mediated transgene expression in vitro and vivo to define an optimal strategy for combining sodium iodide symporter (NIS)-mediated (131)I therapy with EBRT.Expression reporter genes [NIS, green fluorescent protein (GFP), beta-galactosidase (lacZ), luciferase (Luc)] from replication-deficient adenoviruses was assessed tumor cell lines under basal conditions following irradiation. The viral multiplicity infection (MOI)...
We report the outcomes of patients treated with palliative radiotherapy (pRT) to primary tumour in context well-controlled metastatic disease after initial chemotherapy.Clinical records 132 esophago-gastric (OG) cancer chemotherapy (pCT) between January 2009 and June 2013 were reviewed. Ninetyseven had responding or stable 3 months chemotherapy, whom 53 received pRT presence (group A, pCT-RT). The remaining 44 pCT alone B, pCT). Treatment-related assessed above groups including time local...
Radiation has been shown to up-regulate gene expression from adenoviral vectors in previous studies. In the current study, we show that radiation-induced dsDNA breaks and subsequent signaling through mitogen-activated protein kinase (MAPK) pathway are responsible, at least part, for this enhancement of transgene both vitro vivo. Inhibitors ataxia-telangiectasia-mutated, poly(ADP-ribose) polymerase-mutated, DNA-dependent (DNA-PK)-mediated DNA repair were maintain (gammaH2AX foci) by...
Adenoviral (AdV) transfer of sodium iodide symporter (NIS) gene has translational potential, but relatively low levels transduction and subsequent radioisotope uptake limit the efficacy approach. In previous studies, we showed that combining NIS delivery with external beam radiotherapy (EBRT) DNA damage repair inhibitors increased viral expression radioiodide uptake. Here, report therapeutic this strategy. An adenovirus expressing from a telomerase promoter (Ad-hTR-NIS) was cytotoxic...
Introduction Prostate cancer (PCa) is the most common in men. Recurrence may occur up to half of patients initially treated with curative intent for high-risk localised/locally advanced PCa. Pelvic nodal recurrence this setting, but no clear standard care exists these patients, potential therapeutic approaches including stereotactic body radiotherapy (SBRT) involved node(s) alone, extended irradiation (ENI) treat sites micrometastatic spread addition and androgen deprivation therapy or...
Pervious randomized studies have demonstrated survival benefit in favor of tyrosine kinase inhibitors (TKIs) compared to cytokines metastatic clear cell renal carcinoma (RCC). However, the role TKIs for treating brain metastasis from RCC remains unknown. Previous reported possible activity sunitinib and sorafenib patients with metastasis. We report on patient who responded first-line but then progressed multiple metastasis, controlled extra-cranial disease. The was treated whole-brain...