A5077012256- Intensive Care Unit Cognitive Disorders
- Clinical Nutrition and Gastroenterology
- Electrolyte and hormonal disorders
- Family and Patient Care in Intensive Care Units
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Hygrothermal properties of building materials
- Multimedia Communication and Technology
- French Historical and Cultural Studies
- Diet and metabolism studies
- Exercise and Physiological Responses
- Abdominal Surgery and Complications
- Adipose Tissue and Metabolism
- Anesthesia and Sedative Agents
- Muscle metabolism and nutrition
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- Italian Fascism and Post-war Society
- Respiratory Support and Mechanisms
- Pediatric Pain Management Techniques
- Historical and Literary Analyses
- Historical and Literary Studies
- Reformation and Early Modern Christianity
- Building Energy and Comfort Optimization
Clatterbridge Cancer Centre NHS Foundation Trust
2023-2024
University of Liverpool
2007-2016
University of Plymouth
2001-2016
Medical Research Council
2016
Peterborough and Stamford Hospitals NHS Foundation Trust
2015
University of Brighton
1997-2014
Maidstone and Tunbridge Wells NHS Trust
2011-2014
Maidstone Hospital
2014
Schlumberger (British Virgin Islands)
1999-2013
California Maritime Academy
2012-2013
To examine prospectively the relationship between memories of intensive care (ICU) and levels anxiety after ICU discharge, stability these with time, their to development acute posttraumatic stress disorder (PTSD)-related symptoms.Case series cohort assessed by interview at 2 8 wks discharge.District general hospital (serving a population 350,000) unit.Memories were studied in 45 patients discharge. Thirty examined again assess memory PTSD-related symptoms.Standardized interviews...
Patients recovering from critical illness have been shown to be at risk of developing Post Traumatic Stress disorder (PTSD). This study was evaluate whether a prospectively collected diary patient's intensive care unit (ICU) stay when used during convalescence following will reduce the development new onset PTSD.Intensive patients with an ICU more than 72 hours were recruited randomised controlled trial examining effect outlining details on acute PTSD. The intervention received their 1 month...
Objective To evaluate the effectiveness of a rehabilitation program following critical illness to aid physical and psychological recovery. Design Randomized controlled trial, blind at follow-up with final assessment 6 months. Setting Two district general hospitals one teaching hospital. Patients were 126 consecutively admitted intensive care patients meeting inclusion criteria. Interventions Control received ward visits, three telephone calls home, clinic appointments 8 wks Intervention same...
Previous studies have reported that oxidizing free radical species are generated during exercise, and there has been considerable interest in the potential effects of these on exercising tissues. We hypothesized contracting skeletal muscle was a major source untrained would adapt to oxidative stress single short period contractile activity by upregulation cytoprotective proteins absence overt cellular damage. Fifteen minutes aerobic found induce rapid release superoxide anions from mouse...
Oxidative stress induces adaptations in the expression of protective enzymes and heat shock proteins (HSPs) a variety tissues. We have examined possibility that supplementation subjects with nutritional antioxidant, vitamin C, influences ability lymphocytes to express HSPs following exposure an exogenous oxidant response skeletal muscle physiological oxidative occurs during exercise vivo. Our hypothesis was elevation tissue C content would reduce oxidant-induced HSP content. Lymphocytes from...
The exercise-induced expression of heat shock proteins (HSPs) in rodent models is relatively well defined. In contrast, comparable data from human studies are limited and the stress response skeletal muscle far understood. This study has characterized time course magnitude HSP muscles a healthy active, but untrained, young male population following running exercise protocol. Eight subjects performed 45 min treadmill at speed corresponding to their lactate threshold (11.7 ± 0.5 km/h; 69.8...
Background Relatives of patients recovering from critical illness are at risk developing posttraumatic stress disorder. Objectives To test whether providing a diary to intensive care and their relatives reduces the level symptoms related disorder in relatives. Methods Observational study close family members who stayed more than 72 hours an unit, recruited 2 centers 12-center randomized controlled trial examining effect outlining details patients’ stay unit on development new-onset patients....
Percutaneous muscle biopsy is an important and acceptable technique in the study of conditions involving human skeletal muscle. A review 436 conchotome needle biopsies obtained over 18 months this centre presented.
Abstract Introduction and Aims. To examine how young people in New Zealand engage with alcohol reproduce marketing messages alcohol‐related branding ‘Bebo’, a popular social networking site (SNS) on the Internet. Design Methods. Data are drawn from information posted approximately 150 Bebo Web pages analysed by way of textual analysis cyberspace ethnography. Results. Social sites, such as Bebo, provide digital space which to share range via peer‐to‐peer transmission. also enables youth...
Abstract Age-related loss of skeletal muscle mass and function is a major contributor to morbidity has profound effect on the quality life older people. The potential role age-dependent mitochondrial dysfunction cumulative oxidative stress as underlying cause aging remains controversial topic. Here we show that pharmacological attenuation age-related redox changes in with SS31 associated some improvements damage mitophagy muscles old mice. However, this treatment failed rescue fiber atrophy...
Skeletal muscle wasting is commonly observed in critically-ill patients and has been attributed to catabolic fibre atrophy neuropathy. This study describes the occurrence of a necrotizing myopathy 15 out 31 who had percutaneous biopsies taken from tibialis anterior muscles. While most cases showed necrosis isolated fibres, 5 12 serial progressive up 95 per cent fibres. One other case infarction one staphylococcal vasculitis. Atrophy type 1 and/or 2 fibres was documented by morphometry cases....
Background: Although rates vary across studies, research in recent years shows that prevalence of post‐traumatic stress disorder (PTSD) following intensive care unit (ICU) can be high. Presently no screening tool assessing all three PTSD symptom categories has been validated ICU patients. The aim the study was to conduct a preliminary validation such measure, UK‐ Post‐Traumatic Stress Syndrome 14‐Questions Inventory (UK‐PTSS‐14). Methods: A case series cohort performed at two ICUs UK...