A5083553833- Immune cells in cancer
- TGF-β signaling in diseases
- Ferroptosis and cancer prognosis
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Intraperitoneal and Appendiceal Malignancies
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Tryptophan and brain disorders
- Cancer Research and Treatments
- Phagocytosis and Immune Regulation
- Colorectal Cancer Surgical Treatments
- Uterine Myomas and Treatments
- Epigenetics and DNA Methylation
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- Fibroblast Growth Factor Research
- Cancer, Lipids, and Metabolism
- Endometriosis Research and Treatment
- Caveolin-1 and cellular processes
- Immune Cell Function and Interaction
- Diagnosis and treatment of tuberculosis
- Diagnosis and Treatment of Venous Diseases
- Colorectal and Anal Carcinomas
Universitätsklinik für Kinder und Jugendpsychiatrie
2025
Royal Marsden NHS Foundation Trust
2023-2024
Royal Marsden Hospital
2021-2024
Queen Mary University of London
2019-2023
St George’s University Hospitals NHS Foundation Trust
2015-2023
South West London and St George's Mental Health NHS Trust
2015
St George's Hospital
2015
Kingston Hospital NHS Trust
2009
Charing Cross Hospital
2007
Although there are many prospective targets in the tumor microenvironment (TME) of high-grade serous ovarian cancer (HGSOC), pre-clinical testing is challenging, especially as limited information on murine TME. Here, we characterize TME six orthotopic, transplantable syngeneic HGSOC lines established from genetic models and compare these to patient biopsies. We identify significant correlations between transcriptome, host cell infiltrates, matrisome, vasculature, tissue modulus mouse human...
Abstract The tumor microenvironment evolves during malignant progression, with major changes in nonmalignant cells, cytokine networks, and the extracellular matrix (ECM). In this study, we aimed to understand how ECM neoplastic transformation of serous tubal intraepithelial carcinoma lesions (STIC) into high-grade ovarian cancers (HGSOC). Analysis mechanical properties human fallopian tubes (FT) ovaries revealed that normal FT fimbria had a lower tissue modulus, measure stiffness, than or...
Abstract Neoadjuvant chemotherapy (NACT) may stimulate anticancer adaptive immune responses in high-grade serous ovarian cancer (HGSOC), but little is known about effects on innate immunity. Using omental biopsies from HGSOC, and tumors orthotopic mouse HGSOC models that replicate the human tumor microenvironment, we studied impact of platinum-based NACT tumor-associated macrophages (TAM). We found reduces markers associated with alternative macrophage activation while increasing expression...
The correct morphology and migration of neurons, which is essential for the normal development nervous system, enabled by regulation their cytoskeletal elements. We reveal that Neurabin-I, a neuronal-specific F-actin–binding protein, has an function in developing forebrain. show gain loss Neurabin-I expression affect neuronal morphology, neurite outgrowth, radial differentiating cortical hippocampal suggesting tight required forebrain development. Importantly, prevents pyramidal neurons from...
The peritoneal cancer index quantitatively assesses distribution and tumor burden in the cavity. aim of this study is to evaluate association between completeness surgical cytoreduction for ovarian identify a cut-off above which complete unlikely.This single-center prospective cohort observational study. A total 100 consecutive patients who underwent surgery were included. Peritoneal scores prior after calculated, value incomplete was identified using receiver operator characteristic (ROC)...
Introduction Over the last decade there has been a transition from traditional laparoscopy to robotic surgery for treatment of endometrial cancer. A number gynecological oncology surgical fellowship programmes have adopted robot-assisted laparoscopy, but effect training on complications and survival not evaluated. Our aim was assess impact proficiency-based progression curriculum in peri-operative outcomes Methods This is an observational cohort study performed tertiary referral subspecialty...
Background The Global Gynecological Oncology Surgical Outcomes Collaborative (GO SOAR) has developed a network of gynecological oncology surgeons, surgical departments, and other interested parties that have the long-term ability to collaborate on outcome studies. Presented is protocol for GO SOAR2 study. Primary Objectives To compare survival following interval delayed cytoreductive surgery, between surgery no (chemotherapy alone); international variations in access women with stage III–IV...
A 31-year-old Moroccan woman with no significant past medical history was seen during her second pregnancy. At 25 weeks gestation she admitted a febrile illness associated productive cough which treated as community acquired pneumonia oral antibiotics. 31 tender swelling in the right groin and underwent incision drainage of presumed femoral abscess. 36 re-presented multiple skin lesions on arms, legs buttocks. Initial investigation found obvious cause for presentation. The decision induction...
Objective: This study was conducted to find the optimal management for mature cystic teratomas (MCTs) in women age 50 or older. Design: a retrospective longitudinal study. Materials and Methods: Demographic, clinical, biochemical, radiology, surgical, pathology data were collected retrospectively from current authors' electronic patient records all over 50, with preoperative imaging histologic diagnoses of teratomas. The review period 2000 2014. Results: There 32 cases identified an range...
The objective of this study is to evaluate the role laparoscopy in case selection patients for pelvic exenteration treat recurrent cervical or endometrial cancer. Pelvic a rare surgical procedure performed by specialised multidisciplinary teams. We review 55 consecutive laparoscopies being evaluated possible exenterative surgery cancer at single centre UK with significant practice. All had no evidence metastatic disease on imaging prior laparoscopy. Despite thorough radiological assessment...
Although there are many prospective targets in the tumor microenvironment (TME) of high-grade serous ovarian cancer (HGSOC), pre-clinical testing is challenging especially as limited information on murine TME. Here, we have characterized TME six orthotopic, transplantable syngeneic HGSOC lines established from genetic models and compared these to patient biopsies. This analysis identified significant correlations between transcriptome, host cell infiltrates, matrisome, vasculature tissue...
Objective To assess the influence of proficiency-based progression (PBP) training in robot-assisted laparoscopic (RAL) surgery for endometrial cancer on peri-operative and survival outcomes. Design Observational cohort study. Setting Tertiary referral subspecialty centre. Population All women with primary treated RAL between 2015 2022. Methods Proficiency-based cases were identified pre-operatively by consultant surgeons based clinical factors, such as BMI comorbidities, case complexity...
<div>Abstract<p>Neoadjuvant chemotherapy (NACT) may stimulate anticancer adaptive immune responses in high-grade serous ovarian cancer (HGSOC), but little is known about effects on innate immunity. Using omental biopsies from HGSOC, and tumors orthotopic mouse HGSOC models that replicate the human tumor microenvironment, we studied impact of platinum-based NACT tumor-associated macrophages (TAM). We found reduces markers associated with alternative macrophage activation while...
<div>Abstract<p>Neoadjuvant chemotherapy (NACT) may stimulate anticancer adaptive immune responses in high-grade serous ovarian cancer (HGSOC), but little is known about effects on innate immunity. Using omental biopsies from HGSOC, and tumors orthotopic mouse HGSOC models that replicate the human tumor microenvironment, we studied impact of platinum-based NACT tumor-associated macrophages (TAM). We found reduces markers associated with alternative macrophage activation while...
<p>Legend of supplementary tables</p>
<p>CIBERSORT results of the TGFBI high/low samples in TCGA and ICGC datasets</p>
<p>List of antibodies used for flow cytometry</p>
<p>IHC of TGFBI and POSTN</p>
<p>Effect of anti-TGFBI treatment in the HGS2 model</p>