A5102005193- Retinoids in leukemia and cellular processes
- Bioactive Natural Diterpenoids Research
- Phytochemistry and Biological Activities
- Plant Diversity and Evolution
- Cancer, Lipids, and Metabolism
- Aluminum toxicity and tolerance in plants and animals
- Advanced Photocatalysis Techniques
- Plant-based Medicinal Research
- Acute Myeloid Leukemia Research
- Plant Pathogens and Fungal Diseases
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Advanced Mathematical Theories and Applications
- Pickering emulsions and particle stabilization
- Protist diversity and phylogeny
- Synthesis of β-Lactam Compounds
- Drug-Induced Ocular Toxicity
- Epigenetics and DNA Methylation
- Cancer therapeutics and mechanisms
- Pain Mechanisms and Treatments
- Chemotherapy-related skin toxicity
- Medicinal Plants and Bioactive Compounds
- Cognitive Computing and Networks
- Legionella and Acanthamoeba research
- Fibroblast Growth Factor Research
Gansu University of Traditional Chinese Medicine
2024
Qingdao University
2023-2024
Qingdao Municipal Hospital
2023-2024
Affiliated Hospital of Qingdao University
2023
Southwest Medical University
2023
Lanzhou University
2007-2021
Xi'an Jiaotong University
2018
Örebro University Hospital
2018
Karolinska Institutet
2018
421 Hospital of PLA
2016
Spinocerebellar ataxia type 2 (SCA2) is caused by the expansion of a polyglutamine (polyQ) repeat in ataxin-2, SCA2 gene product. In contrast to other polyQ diseases, intranuclear inclusions are not prominent SCA2. animal models with expression mutant ataxin-2 targeted Purkinje cells, neuronal dysfunction and morphologic changes observed without formation aggregates. this report, we investigated mechanisms underlying pathogenesis using cellular models. We confirmed that product, was...
Purpose To evaluate the effects of chromium (Cr) and magnesium (Mg) ions on metabolic profiles, inflammation, oxidative stress with impaired glucose tolerance (IGT) insulin resistance (IR). Methods 120 individuals IGT IR were randomly divided into four groups treated (1) chromium, (2) magnesium, (3) or (4) placebo. Metabolic inflammatory indicators measured at baseline after 3 months intervention. Results Comparison among showed that fasting plasma (FPG), 2 h post (2hPPG), (FINS) homeostatic...
Alzheimer's disease (AD)-related brain deterioration is linked to the type 2 diabetes mellitus (T2DM) features hyperglycemia, hyperinsulinemia, and insulin resistance. Hypoxia as a common risk factor for both AD T2DM. Hypoxia-inducible factor-1 alpha (HIF-1α) acts main regulator of hypoxia response may be key target in comorbidity HIF-1α expression closely related resistance, inflammation. Tissue oxygen consumption disrupts homeostasis, leading increased reactive species levels inhibition...
Rationale: Immunotherapy with immune checkpoint inhibitors (ICI) has shown promising activity against many tumor types. However, they can also induce a wide array of immune-related adverse events, ranging from mild to fatal. Primary 3 endocrine gland insufficiency during treatment ICI rarely been reported. Patient concerns: We report the case 33-year-old man Ewing sarcoma who was treated toripalimab as second-line treatment. Approximately 11 months after initiating treatment, patient...
A Gram-negative, extremely halophilic, coccoid archaeal strain, CM5 T , was isolated from a crude sea-salt sample collected near Qingdao, China. The organism grew optimally at 35–40 °C and pH 6.0 in the presence of 20 % (w/v) NaCl. Its colonies were red colour it could use glucose as sole carbon source for growth. 16S rRNA gene sequence most closely related to those Halococcus species. pattern antibiotic susceptibility similar other described Biochemical tests revealed no sign H 2 S...
Crocrassins A (<bold>1</bold>) and B (<bold>2</bold>), two novel sesquiterpenoids with a unique skeleton, were isolated from Chinese medicinal plant <italic>Croton crassifolius</italic>.
Abstract Deguelin, a natural component derived from leguminous plants, has been used as pesticide in some regions. Accumulating evidence show that deguelin promising chemopreventive and therapeutic activities against cancer cells. This study shows low concentrations of can lead to significant delay zebrafish embryonic development through growth inhibition induction apoptosis. Furthermore, we identified fibroblast factor receptor 4 ( FGFR 4) the putative target deguelin. The candidate was...
The aim of this work is to develop curcumin-loaded hollow mesoporous silica microspheres (HMSMs@curcumin) improve the poor oral bioavailability curcumin. Hollow (HMSMs) were synthesized in facile route using a hard template. HMSMs and HMSMs@curcumin characterized by scanning electron microscopy (SEM), transmission (TEM), nitrogen adsorption/desorption measurements, differential calorimetry (DSC), Fourier transform infrared (FTIR), X-ray diffraction (XRD). In addition, demonstrate potential...
= 11.2, H-12)], which represented the structure moieties C-1–C-5 and C-7–C-12 of a lathyrane diterpenoid, respective-ly. The HMBC correlations enable assembly units A andB with quaternary carbons other functionalities. TheHMBC H-5 C-3, C-6, C-7, C-17,correlations H-12 C-11, C-13, C-14, C-20, andcorrelations H
QTc prolongation has been observed during arsenic trioxide and realgar's clinical use, become a huge obstacle for the application. Our lab obtained soluble from realgar named transforming solution or RTS. In this study, we first evaluated cytotoxicity on NB4 cell found that RTS could remarkably inhibit proliferation of than trioxide. Then figured out treatment contrasted with trioxide; results revealed prolonged corrected mice by 20.1% showed 1.9-fold higher H9c2 On contrary, there not find...
A versatile template biomaterial was facilely obtained by ultraviolet (UV) photocrosslinking approach using protein molecules as building blocks. As-formed photocrosslinked hydrogel matrix (PPHM) proved to be composed of covalently bound and dense packing molecules. Therefore, the PPHM endowed with highly smooth topograghy an average roughness approximately 5 nm, self-supporting flexible. The could easily functionalized doping Fe3O4 magnetic nanoparticles inside hydrogel. Further,...
Bleomycin is an antibiotic with cytotoxic properties that commonly used in combination regimens for the treatment of Hodgkin lymphoma. The inconsistency dosage nomenclature bleomycin appears universally, which increases risk medication errors. However, to best our knowledge, no such cases have been reported. Herein, we present a rare case report error caused by overdose. At third cycle chemotherapy, 25-year-old patient stage II lymphoma received 10 times higher dose (150 USP) than usually as...
-elasticity of network that measure the invulnerability and node resilience importance are put forward in case great amount calculation finite field application existing metrics. The disadvantages vulnerability node，the ,the tenacity, betweenness point out through comparability. -resilience certain varies types scales networks calculated compared, result comparability analysis is metrics this paper confined effective measuring aspects exactness. available designing evaluating invulnerability.
Abstract Background The risk of psoriasis in breast cancer patients is largely unknown, as available evidence limited to case findings. We systematically examined the incidence and factors patients. Methods Using Cox regression models, a Swedish nationwide cohort 56,235 (2001-2012) was compared 280,854 age-matched reference individuals from general population estimate hazard ratio (HR) psoriasis. also calculated HRs for according treatment, genetic lifestyle regional 8,987 Results In cohort,...