A5045756342- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Palliative Care and End-of-Life Issues
- Colorectal and Anal Carcinomas
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Childhood Cancer Survivors' Quality of Life
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Breast Cancer Treatment Studies
- Colorectal Cancer Surgical Treatments
- Intestinal and Peritoneal Adhesions
- Photodynamic Therapy Research Studies
- Intraperitoneal and Appendiceal Malignancies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Colorectal Cancer Screening and Detection
- Melanoma and MAPK Pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Treatments and Studies
- Optical Coherence Tomography Applications
- Management of metastatic bone disease
- Nonmelanoma Skin Cancer Studies
- Pain Management and Opioid Use
- AI in cancer detection
Princess Margaret Cancer Centre
2013-2024
University Health Network
2013-2024
Mount Sinai Hospital
2012-2024
University of Toronto
2012-2024
Cancer Institute (WIA)
2009
Ontario Institute for Cancer Research
2009
American College of Surgeons
2002
Harvard University
1998
Massachusetts General Hospital
1998
Ottawa Regional Cancer Foundation
1996
Adoptive cell therapy using autologous tumor-infiltrating lymphocytes (TIL) has shown significant clinical benefit, but is limited by toxicities due to a requirement for post-infusion interleukin-2 (IL-2), which high dose standard. To assess modified TIL protocol lower IL-2, we performed single institution phase II in unresectable, metastatic melanoma. The primary endpoint was response rate. Secondary endpoints were safety and assessment of immune correlates following infusion. Twelve...
Regulatory T (Treg) cells expressing the transcription factor FOXP3 are essential for maintenance of immunologic self-tolerance but play a detrimental role in most cancers due to their ability suppress antitumor immunity. The phenotype human circulating Treg has been extensively studied, less is known about tumor-infiltrating cells. We studied and function ovarian cancer melanoma identify potential cell-associated molecules that can be targeted by tumor immunotherapies.
Background: For patients who are diagnosed with early-stage cutaneous melanoma, the principal therapy is wide surgical excision of primary tumour and assessment lymph nodes. The purpose present guideline was to update 2010 Cancer Care Ontario on local margins sentinel node biopsy (slnb), including treatment positive node, for melanomas trunk, extremities, head neck. Methods: Using Ovid, medline embase electronic databases were systematically searched systematic reviews literature evaluating...
Background Various immunotherapeutic strategies for cancer are aimed at augmenting the T cell response against tumor cells. Adoptive therapy (ACT), where cells manipulated ex vivo and subsequently re-infused in an autologous manner, has been performed using from various sources. Some of highest clinical rates metastatic melanoma have reported trials tumor-infiltrating lymphocytes (TILs). These protocols still room improvement furthermore currently only a limited number institutions. The goal...
Abstract Almost all genomic studies of breast cancer have focused on well-established tumours because it is technically challenging to study the earliest mutational events occurring in human epithelial cells. To address this we created a unique dataset samples ductoscopically obtained from ducts leading carcinomas and matched opposite side nipple. Here, demonstrate that perturbations mRNA abundance, with increasing proximity tumour, cannot be explained by copy number aberrations. Rather,...
Educational demands coupled with restricted hours reduce residents' availability to provide care at academic hospitals. Physician assistants (PAs) may address this issue. This study assessed the effect of PAs on patient discharges, resident workload, and perceptions a surgical team.Two were employed teams caring for complex patients. Measures included time discharge order entry, residents spent electronic medical record (EMR), opinions PA effectiveness.The had 0.5% late 16% early rate....
Abstract Background Re-excision due to positive margins following breast-conserving surgery (BCS) negatively affects patient outcomes and healthcare costs. The inability visualize margin involvement is a significant challenge in BCS. 5-Aminolevulinic acid hydrochloride (5-ALA HCl), non-fluorescent oral prodrug, causes intracellular accumulation of fluorescent porphyrins cancer cells. This single-center Phase II randomized controlled trial evaluated the safety, feasibility, diagnostic...
Background: Patients undergoing colorectal surgery are vulnerable during their transition from hospital to home and require increased support following discharge hospital. Study objectives were perform an initial assessment of patient uptake, outcomes, satisfaction with integrated monitoring system called Home Stay. Methods: The intervention was that uses a mobile app platform. downloaded the prior received Daily Health Check day #1 #14, #21, #30. Patient responses’ accessed by health-care...
Patterns of failure and long term outcomes were prospectively evaluated following tumor factors-stratified radiation dose for anal/perianal cancer.Between 2008-2013, patients with squamous cell carcinoma accrued to an institutional REB-approved prospective study. All treated image-guided intensity-modulated therapy (IG-IMRT). Radiation selection (27-36 Gy elective target, 45-63 gross target) was based on clinico-pathologic features. Chemotherapy regimen 5-fluorouracil/mitomycin-C (weeks...
A randomized controlled trial was conducted to evaluate the effect of a postdischarge app on 30-day readmissions and patient-reported outcomes following colorectal surgery.Patients undergoing surgery are particularly vulnerable during their transition from hospital-to-home. There has been increasing interest in e-health provide cost-effective transitional care. An integrated discharge monitoring program using mobile platform developed support patients after surgery.A 2 arm, superiority...