Deep learning (DL) based image processing methods have been successfully applied to low-dose x-ray images on the assumption that feature distribution of training data is consistent with test data. However, computed tomography (LDCT) from different commercial scanners may contain amounts and types noise, violating this assumption. Moreover, in application DL LDCT, distributions LDCT simulation clinical CT examination can be quite different. Therefore, network models trained simulated or one...

An iron(III)-mediated nucleophilic cascade cyclization of N-propiolyl enamides with various diselenides was developed, which provides an efficient way to construct seleno-heterocycles. A mechanism study shows that the process involves selective addition C≡C bond generating a seleniranium ion, followed by intramolecular attack enaminic carbon tertiary enamide. Utilizing this protocol, variety 3-seleno-2-pyridones were successfully synthesized featuring good functional group compatibility and...

A Mn(III)-mediated radical cascade cyclization of N-propargyl enamides with sodium sulfinates was developed. Mechanistic studies indicated that this process is mainly composed the chemoselective addition sulfonyl to C≡C bond and regioselective intramolecular 6-endo-trig cyclization. This protocol provided a powerful method for divergent synthesis diverse polysubstituted meta-sulfonylpyridines or 1,2-dihydropyridines just by varying solvent temperature featuring good functional group...

In recent years, low-dose computed tomography (LDCT) has played an important role in the diagnosis CT to reduce potential adverse effects of X-ray radiation on patients, while maintaining same diagnostic image quality.Deep learning (DL)-based methods have increasingly field LDCT imaging. However, its performance is highly dependent consistency feature distributions between training data and test data. Due patient's breathing movements during acquisition, paired normal dose images are...

Background/Objectives: With the advancement of intelligent sensing technology, rehabilitation systems based on wearable devices have a positive impact functional recovery and quality life stroke patients. This study aims to evaluate application value contextualized training system for survivors, which is devices, in motor function impairments following stroke. Methods: A randomized controlled trial design was employed, 100 patients were randomly divided into control group (n = 50, receiving...

Functionalized pyridines and 1,2‐dihydropyridines are crucial organic entities in natural products, materials, drugs catalysts. Despite progress, a facile eco‐friendly synthesis remains desirable so far. In this context, we disclose novel visible light‐promoted radical cascade sulfonylation‐cyclization‐aromatization of N‐propargyl enamides with selenosulfonates. This approach avoids the use metal‐ or photocatalyst, bases external oxidants, marking significant advance sustainable green...

A copper(II)-catalyzed radical cascade reaction of N-propargyl enamides with sulfonyl hydrazides was developed, which provided an unprecedented method for the direct synthesis meta-sulfonylpyridines in high efficiency good functional group compatibility and simple operation. Mechanistic studies indicated that this tandem process might be composed addition, intramolecular cyclization oxidative aromatization.

Stroke is a serious cerebrovascular disease, and rehabilitation following the acute phase particularly crucial. Not all outcomes are favorable, highlighting necessity for personalized rehabilitation. Precision assessment essential tailored interventions. Wearable inertial measurement units (IMUs) deep learning approaches have been effectively employed motor function prediction. This study aims to use machine techniques data collected from IMUs assess Fugl-Meyer upper extremity subscale...

A catalytic enantioselective conjugate addition with commercially available allenylboronic acid pinacol ester as nucleophile promoted by a chiral copper complex of N-heterocyclic carbene (NHC) is disclosed. This process constitutes an unprecedented instance the that introduces allenyl group into α,β-unsaturated carbonyl compounds, affording products are otherwise difficult to access in up 92% yield, >98% selectivity and 96:4 enantiomeric ratio. DFT calculations were performed elucidate...

Abstract Low-dose computed tomography (LDCT) has gained increasing attention owing to its crucial role in reducing radiation exposure patients. However, LDCT-reconstructed images often suffer from significant noise and artifacts, negatively impacting the radiologists’ ability accurately diagnose. To address this issue, many studies have focused on denoising LDCT using deep learning (DL) methods. these DL-based methods been hindered by highly variable feature distribution of data different...

Aiming at the characteristic of infrared image whose background is complicate and noise serious, this paper puts forward a fused detection algorithm based on energy accumulation morphology. The can restrain Gauss distribution effectively. morphological top-hat operator remove efficiently. Firstly, analyze characteristics small target, in establish mathematical model. Secondly, by accumulation. Thirdly, operator. Finally, do binarization global threshold, obtain target few remainder opening...

Abstract Development, validation and application of an HPLC assay for new antiviral nucleoside analogues AM365 AM188 in isolated perfused rat liver perfusate bile were performed. An analytical column (Phenosphere‐NEXT, 250 × 4.6 mm, C 18 , 4 µm, Phenomenex) was used tandem with a guard (4 3 operated at 25°C. The mobile phase [methanol:10 mmol/L sodium orthophosphate buffer (pH 7.0), 15:85, v/v] pumped 1 mL/min. signal from diode array detector collected 190 to 300 nm. chromatogram processed...

Background Complete pathologic response following neoadjuvant therapy (NAT) for pancreatic ductal adenocarcinoma (PDAC) is rare; alternative markers associated with survival are needed. The aim of this study was to evaluate the impact tumor NAT on overall (OS) in PDAC patients who received and curative-intent surgery. Methods A retrospective utilizing 2006-2018 National Cancer Database identified 6,960 adult NAT. As a comparator group, 15,799 underwent upfront surgical resection were...

WeiR.ChenUniversity of Central OklahomaDepartment Physics and EngineeringEdmond, Oklahoma 73034andUniversity AstronomyNorman, 73109E-mail: wchen@ucok.eduHong LiuUniversity OklahomaCenter for Bioengineering School ofElectrical EngineeringNorman, 73019Wei YueJiping WangUniversity VirginiaDepartment Internal MedicineCharlottesville, Virginia 22908Robert E. NordquistUniversity OphthalmologyOklahoma City, 73104andWound Healing Oklahoma, Inc.3945 North Walnut StreetOklahoma 73105Abstract....

Traditional deep learning reconstruction (DLR) methods have been sparsely applied in practical low-dose computed tomography (LDCT) imaging, as they heavily rely on the similarity between latent distributions of data features. However, real LDCT imaging scenarios, distribution features is highly diverse and complex, which limits generalizability existing DLR methods. Recently, diffusion models shown great potential field some early studies used them to address domain generalization problem....

Optical physiotherapy system can bring effective treatment for skin diseases and arthritis. On the one hand, using artificial light such as infrared, ultraviolet, visible or laser to irradiate lesion area, local heating by wave improve tissue vitality, promote collagen production, achieve purpose of disease prevention treatment. other feeding back signals specific bands human body, imbalance function be adjusted health status. In this work, a uniform phototherapy based on multi-band LED is...