A5023390470- Virus-based gene therapy research
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Bioactive natural compounds
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Reproductive tract infections research
- Neonatal Respiratory Health Research
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- TGF-β signaling in diseases
- Genomics and Phylogenetic Studies
- COVID-19 Pandemic Impacts
- Infections and bacterial resistance
- Phytochemicals and Antioxidant Activities
Brigham Young University
2024
Army Medical College
2019-2023
National University of Medical Sciences
2019-2023
Beijing Institute of Technology
2020-2022
COMSATS University Islamabad
2021
Military Hospital
2021
Beijing University of Technology
2017-2019
N6-Methyladenosine (m6A) is the most prevalent internal modification that occurs in mRNA of eukaryotes and plays a vital role post-transcriptional regulation. Recent studies highlighted biological significance m6A nervous system, its dysregulation has been shown to be related degenerative neurodevelopmental diseases. Parkinson's disease (PD) common age-related neurological disorder with pathogenesis still not fully elucidated. Reports have epigenetic mechanisms including DNA methylation...
There is an urgent need for targeted biological therapies prostate cancer with greater efficacy and less toxicity, particularly metastatic disease, where current are not curative. Therapeutic adenoviral vectors or oncolytic adenoviruses offer the possibility of a competent, nontoxic therapeutic alternative cancer. However, free viral particles must be delivered locally, approach that does address they display poor tumor penetration. To fully exploit potential these vectors, we develop...
The high-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. deletions mutations of the tumor suppressor PTEN (5%-40%) in patients are associated with worse survival therapeutic resistance. Characterization unique prognosis molecular signatures status still unclear. This study established a novel risk model, screened optimal prognostic signatures, calculated score for individual different status. Screening results revealed fourteen independent PTEN-wt...
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), a derivate of dopamine, is suspected to be the most probable neurotoxin in degeneration dopaminergic neurons. Numerous hypotheses regarding its pathophysiological roles have been raised, especially related Parkinson's disease and alcohol addiction. In mammalian brain, salsolinol may enzymatically synthesized by synthase from dopamine acetaldehyde. However, direct evidence biosynthesis was still missing. this study, we...
Abstract Breast cancer is the most prevalent malignancy in women, which remains untreatable once metastatic. The treatment of advanced breast restricted due to chemotherapy resistance. We previously investigated anti-cancer potential a tumor selective oncolytic adenovirus along with cisplatin three lung cells; A549, H292, and H661, found it very efficient. To our surprise, this virotherapy showed remarkable cytotoxicity chemo-resistant cells. Here, we extended investigation by using two...
Objective.Conditionally replicating adenoviruses (CRAds) have been proven potent oncolytic viruses in previous studies.They selectively replicate the tumor cells because of incorporated survivin promoter and ultimately lead to their killing with minimal side effects on normal tissue.Chemotherapy cisplatin is commonly employed for treating tumors, but its cytotoxic development resistance remained major concerns be dealt with.The aim this study was explore anticancer potential regulated CRAd...
Abstract Ten‐eleven translocation 1 (TET1), a widely reported DNA demethylation protein, has been associated with tumorigenesis and metastasis. However, whether TET1 is an oncogene or tumor suppressor gene controversial; the mechanism of how affects cancer progression remains unclear. The current study aims to investigate changed in microenvironment explore mechanisms colon progression. Because hypoxia prevails on solid tumors, we established important connection between tumorigenesis. By...
Characterization of the global genetic diversity bovine leukemia virus (BLV) is an ongoing international research effort. Up to now BLV sequences have been classified into eleven distinct genotypes. Although genotyping and molecular analysis field isolates were reported in many countries, there no report describing genotypes present cattle from Pakistan. In this study we examined 27 env gene BLV-infected coming four farms located Khyber Pakhtunkwa, Gilgit Baltisan Punjab provinces....
Cisplatin is ranked as one of the most powerful and commonly prescribed anti-tumor chemotherapeutic agents which improve survival in many solid tumors including non-small cell lung cancer. However, treatment advanced cancer restricted due to chemotherapy resistance. Here, we developed investigated survivin promoter regulating conditionally replicating adenovirus (CRAd) for its potential alone or combination with cisplatin two cells, H23, H2126, their resistant H23/CPR, H2126/CPR. To measure...
ABSTRACT This announcement contains the whole genome sequences of five Ackermannviridae that infect members Enterobacteriaceae family bacteria. Four phages were isolated using Salmonella enterica serovar Typhimurium as a bacterial host: AR2819, Sajous1, SilasIsHot, and FrontPhageNews. ChubbyThor was Shigella boydii .
Members of Enterobacterales are very common pathogens, which continue to show resistance many antibiotics. Carbapenem performed well for some time. Colistin was the final hope carbapenem-resistant Enterobacterales, but against it has virtually tied clinician's hands, especially when comes treating critically ill patients.Detection colistin by agar method as polymerase chain reaction (mobilized resistance-1 gene) in Enterobacterales.A cross-sectional study from Dec 2019 2020 conducted at...
We investigated the occurrence and diet of two sympatric mongoose species; small Indian Urva auropunctatus grey Herpestes edwardsii inhabiting Margalla Hills National Park, Islamabad, Pakistan. The species occurred in park at elevations between 537 m 1363 a.s.l., with occurring higher than mongoose. Out 23 sites sampled, only three were common to both species. mongooses, determined through food remains scats, comprised mammals (rodents, shrews), insects, birds, reptiles seeds fruits. Rodents...
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis (EBL), which has been reported worldwide. The expression viral structural proteins: surface glycoprotein (gp51) and three core proteins - p15 (matrix), p24 (capsid), p12 (nucleocapsid) induce a strong humoral cellular immune response at first step infection. CD4+ T-cell activation generally induced by leukocyte antigen (BoLA) region- positive antigen-presenting cells (APC) after processing an exogenous antigen....
Abstract Hypermethylation of gene promoter has been indicated for the contribution silencing, and DNA demethylating drugs, such as 5‐aza‐2'‐deoxycytidine (DAC), used clinically cancer treatment. However, reason why a proportion genes with hypermethylated exhibit high expression levels remains unclear this drug is not much successful expected in use. Furthermore, CpG islands (CGIs) are found to be located only promotors, but also bodies. By RNA‐seq reduced representation bisulfite sequencing,...
The objective of this study was to determine the true seroprevalence bovine leukemia virus (BLV) infection in dairy cattle from Pakistan at animal and herd-level. We tested 1380 451 herds 92 water buffalo. sera were by ELISA results analyzed using Bayesian inference. median posterior estimate herd level BLV prevalence 1.4%, with a 95% credible interval (CI) 0.7–3.1, whereas within-farm 3.8% CI 2.8–4.8. All collected buffalo negative. Several risk factors potentially associated seropositivity...