A5101871755- Wound Healing and Treatments
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- TGF-β signaling in diseases
- Curcumin's Biomedical Applications
- Food and Agricultural Sciences
- Hormonal Regulation and Hypertension
- Liver physiology and pathology
- Electrospun Nanofibers in Biomedical Applications
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Aldose Reductase and Taurine
- Chronic Kidney Disease and Diabetes
- Angiogenesis and VEGF in Cancer
- Peptidase Inhibition and Analysis
- Ecology and Conservation Studies
- Traditional Chinese Medicine Analysis
- Diabetic Foot Ulcer Assessment and Management
- ATP Synthase and ATPases Research
- Botany and Plant Ecology Studies
- Metal complexes synthesis and properties
- Cytomegalovirus and herpesvirus research
- Nuclear Receptors and Signaling
- Natural product bioactivities and synthesis
- Turfgrass Adaptation and Management
Mudanjiang Medical University
2015-2025
First Affiliated Hospital of Soochow University
2024
Sichuan University
2024
West China Second University Hospital of Sichuan University
2024
Soochow University
2024
Cangzhou Central Hospital
2023
University of Louisville
2020
Jinan University
2014
Brigham and Women's Hospital
2014
Beijing Academy of Agricultural and Forestry Sciences
2010
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes that structurally characterized by glomerular basement membrane thickening, extracellular matrix accumulation, destabilization podocyte foot processes. MicroRNAs (miRNAs) are dysregulated in DN, but identification the specific miRs involved remains incomplete. Here, we confirm peripheral blood from patients with kidneys animals type 1 or 2 have low levels miR-23b compared those their nondiabetic counterparts....
The application of gelatin hydrogels is hampered by their poor mechanical properties, which are unfavorable for debridement and diabetic wound healing. Herein, bovine serum albumin (BSA)-bridged biopotentiated bone marrow mesenchymal stem cell (BMSC)-derived nanovesicles (NV), named [email protected], were fabricated reinforcement with genipin BSA in a one-pot, low-cost green approach based on amide bonding-guided crosslinking. Genipin introduction endowed the crosslinking weak properties...
Perfluorooctane sulfonate (PFOS) is a synthetic material that has been widely used in industrial applications for decades. Exposure to PFOS associated with decreased adult testosterone level, and Leydig cell impairment during the time of adulthood. However, little known about effects utero on fetal cells (FLC).The present study investigated FLC function. Pregnant Sprague Dawley female rats received vehicle (0.05% Tween20) or (5, 20 mg/kg) by oral gavage from gestational day (GD) 11-19. At...
Recent studies showed that transplantation of mesenchymal stem cells (MSCs) significantly decreased tissue fibrosis; however, little attention has been paid to its efficacy on attenuating skin fibrosis, and the mechanism involved in effect is poorly understood. In this work, we investigated effects MSCs keloid fibroblasts extracellular matrix deposition through paracrine actions whether antifibrotic properties transforming growth factor-β (TGF-β)-dependent activation. vitro experiments...
Diabetic nephropathy is characterized by persistent albuminuria, progressive decline in GFR, and secondary hypertension. MicroRNAs are dysregulated diabetic nephropathy, but identification of the specific microRNAs involved remains incomplete. Here, we show that peripheral blood from patients with diabetes kidneys animals type 1 or 2 have low levels microRNA-25 (miR-25) compared those their nondiabetic counterparts. Furthermore, treatment high glucose decreased expression miR-25 cultured...
Diabetes-induced oxidative stress is one of the major contributors to dysfunction endothelial progenitor cells (EPCs) and impaired regeneration. Thus, we tested whether increasing antioxidant protein metallothionein (MT) in EPCs promotes angiogenesis a hind limb ischemia (HLI) model MT transgenic (JTMT) mice with high-fat diet– streptozocin-induced diabetes. Compared littermate wild-type (WT) diabetic mice, JTMT had improved blood flow recovery after HLI. Similarly, transplantation bone...
Stem cell injection is an effective approach for treating diabetic wounds; however, shear stress during injections can negatively affect their stemness and growth. Cell-laden porous microspheres provide shelter bone mesenchymal stem cells (BMSC). Herein, curcumin-loaded flower-like (CFPM) are designed by combining phase inversion emulsification with thermally induced separation-guided four-arm poly (l-lactic acid) (B-PLLA). Notably, the CFPM shows a well-defined surface topography inner...
Diabetic wound healing remains a worldwide challenge for both clinicians and researchers. The high expression of matrix metalloproteinase 9 (MMP9) inflammatory response are indicative poor diabetic healing. H8, curcumin analogue, is able to treat diabetes anti-inflammatory, our pretest showed that it has the potential However, H8 highly expressed in organs such as liver kidney, resulting its unfocused use targeting. (These data were not published, see Table S1 Supporting Information.)...
Background: Severe endometrial injury constitutes a significant risk to female fertility, often leading the development of intrauterine adhesions. Pyroptosis, form programmed cell death associated with inflammation, is initiated by cleavage gasdermin family proteins caspase, which has been implicated in injury. In recent years, hydrogen sulfide (H2S), gaseous signaling molecule, exerts regulatory effects on pyroptosis diverse pathological processes. The aim this study elucidate role H2S...
Introduction Abdominal Aortic Aneurysm (AAA) is a common vascular disease characterized by progressive expansion and remodeling of the aortic wall. However, with gradual blood vessels, walls vessels cannot withstand tension rupture, jeopardizing people’s health. Methods The aim experiment was to establish an abdominal aneurysm model in rats applying porcine pancreatic elastase externally, measure diameter thickness as well hemodynamics using animal ultrasound, active contraction rate...
We investigated the effect of an 11β-HSD1 inhibitor (H8) on hepatic steatosis and its mechanism action. Although H8, a curcumin derivative, has been shown to alleviate insulin resistance, non-alcoholic fatty liver disease (NAFLD) remains unknown. Rats were fed high-fat diet (HFD) for 8 weeks, intraperitoneally injected with streptozotocin (STZ) induce NAFLD, and, then, treated H8 (3 or 6 mg/kg/day) (6 4 evaluate effects NAFLD. significantly alleviated HFD+STZ-induced lipid accumulation,...
Wound healing is a complicated event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. MicroRNAs (miRNAs) have been proved to play an important role the process of skin trauma, alteration specific miRNA expression during different phases may be associated with abnormal wound healing. In this study, we determined variation miR-23b after trauma normal mice cultured cells exposed lipopolysaccharide. We further demonstrated excessive could significantly...
Abstract Background Liver fibrosis is a progressive liver injury response. Transforming growth factor β1 (TGF-β1) oversecreted during and promotes the development of fibrosis. Therapeutic approaches targeting TGF-β1 its downstream pathways are essential to inhibit The N-terminal latency-associated peptide (LAP) blocks binding receptor. Removal LAP critical for activation TGF-β1. Therefore, inhibition by may be potential approach affect Methods Truncated (tLAP) plasmids were constructed....
Abstract Accumulating evidence indicates that cellular premature senescence of the glomerulus, including endothelial cells, mesangial and podocytes leads to diabetic nephropathy (DN), DN is regarded as a clinical model senescence. However, role senescence‐associated genes in glomerulus progression remains unclear. Therefore, this work aims identify validate potential aging‐related provide novel clues for treatment based on anti‐aging. The microarray GSE96804 dataset, 41 glomeruli 20 control...