High-density lipoprotein (HDL) levels are inversely proportional to the risk of atherosclerosis, but mechanisms HDL atheroprotection remain unclear. Monocyte chemoatractant protein-1 (MCP-1) constitutes an early component inflammatory response in atherosclerosis. Here we investigated influence on MCP-1 production vascular smooth muscle cells (VSMCs) and rat aortic explants.HDL inhibited thrombin-induced a concentration-dependent manner. The HDL-dependent inhibition was accompanied by...

We evaluate a spillover effect of the Japanese public long-term care insurance (LTCI) as policy to stimulate family caregivers' labor force participation. Using nationally representative data from 1995 2013, we apply difference-in-difference propensity score matching investigate in two periods: before and after introduction LTCI 2000 its major amendment 2006. Our results show that has significant positive effects on participation vary by gender age. In contrast, is found have generally...

Objective— Plasma high density lipoprotein (HDL) levels have been shown to be inversely correlated with coronary artery disease, but the mechanisms of direct protective effect HDL on endothelial cells (ECs) are not fully understood. In this study, we investigated role HDL-mediated promotion angiogenesis in human ECs (HCECs). Methods and Results— We developed an vitro model HCEC tube formation a matrix gel. optimized maximum dose required induce initial experiments, which response showed that...

To determine whether disc displacement (DD) can be a factor causing changes in condylar position the glenoid fossa, using limited cone beam CT (LCBCT) images taken same time period as MRI that verified DD.The study included 60 joints 57 male and female subjects aged 12-20 years (mean age 14.8 years). Subjects fulfilling inclusion criteria were enrolled from pool of post-orthodontic patients, divided into four groups according to their status confirmed by MRI: partial DD (PDD), total with...

No quantitative standards for the optimal position of mandibular condyle in glenoid fossa are yet available coronal and axial planes. We previously reported measurements this sagittal plane, using recently developed limited cone-beam computed tomography (LCBCT) capable imaging craniofacial structures with high accuracy. In study, we assessed condylar planes.The study included 24 joints 22 asymptomatic patients (10 male, 12 female; age range 12-25 years, mean 18 years) who had no disc...

Previous studies conducted in Japan targeted only mothers who cared for children with disabilities, and lacked reference subjects, such as of without disabilities. The aim this study was to examine the association between raising one or two a disability maternal psychological distress compared disability, assess differences among partnered living grandparent(s), single mothers.This utilized data from Comprehensive Survey Living Conditions (CSLC) 2010. We merged (aged six over), mothers,...

Background The coronary artery calcification (CAC) score measured by multidetector row computed tomography (MDCT) has emerged as a marker for predicting disease (CAD). To evaluate the clinical significance of CAC score, stenosis assessed angiography (CAG) was compared with determined MDCT, risk factors and medications. Methods Results Subjects included 374 consecutive patients who underwent ECG-gate CT using MDCT. accuracy in ≥400 84%, significantly lower than that =0. In addition 92 (68...

<title>Abstract</title> This study examines healthcare utilization patterns among Japan’s older population (aged 75 and above) during a prolonged public health emergency, focusing on the later phase of COVID-19 pandemic (November 2021-September 2022). period was characterized by Omicron variant, widespread vaccination coverage, adapted measures. Using comprehensive dataset 189,841,257 medical claims linked with income tax records, we analyze how correlates measures, severity, levels. Our...

Objective Pentraxin 3 (PTX3) is a novel candidate immunoinflammatory marker that has been reported to be associated with cardiometabolic risk factors and predict adverse outcomes in patients coronary artery disease. The purpose of this study was investigate the association between plasma levels PTX3 plaque vulnerability effect using statin Methods We determined associations among nonculprit lesions stenosis as assessed by integrated backscatter intravascular ultrasound (study 1). One hundred...

Abstract Purpose There has been no study on the prevalence of disc displacement (DD) different levels in children and adolescents with adequate sample size using magnetic resonance images (MRIs). This retrospective cross‐sectional was designed to investigate relationship between increasing age DD various severities a young preorthodontic population. Materials Methods Of 199 patients aged 6 15 years visiting private orthodontic office for initial examination, 153 signs symptoms...

It is widely documented that psychological distress negatively associated with social networks involvement. However, despite the theoretical postulations are crucial for alleviating distress, no study has yet empirically confirmed causality of this relationship. Thus, we used random-effects generalized least squares method to investigate effect one- and two-year lagged values involvement in on distress. Nine years longitudinal data were extracted from a nationally representative survey Japan...

To determine the resident and facility characteristics associated with residents' care-need level deterioration in long-term care welfare facilities Japan.A nationally representative sample of 358 886 residents who lived 3774 for at least 1 year from October 2012 was obtained insurance claims data. Facility were linked a survey institutions establishments 2012. We used multilevel logistic regression according to inclusion exclusion lost follow-up define deteriorations (lost follow-up:...

The association between metabolic syndrome (MetS) and the severity of coronary artery disease (CAD) as determined by multidetector row computed tomography (MDCT) is unclear.The number significantly stenosed vessels (VD), calcification score, visceral fat area (VFA), subcutaneous (SFA), abdominal circumference were quantified using MDCT. Plasma levels factors also measured. adiponectin negatively correlated with body mass index, diastolic blood pressure, triglycerides, hemoglobin A(1c),...

Home independence is an important issue for the elderly in many countries and cultures. The aim of this study was to examine effect short-stay service use on stay-at-home duration people by level care need under Japanese long-term insurance system.

A 51-year-old woman with a large uterine myoma suffered from acute pulmonary throm boembolism. Venography revealed thrombosis in the right common iliac vein and almost complete obstruction of left vein. The ascending lumbar showed collateral drainage. Treatment was initiated continuous intravenous heparin sodium, Greenfield filter inserted to prevent extension embolism during after hysterectomy. After total hysterectomy, venography restora tion patency bilateral veins, no flow seen Thorough...

In rat models of transplant vasculopathy, the strongest staining CXCR3 is observed in innermost layer neointima and because neointimal hyperplasia seen after coronary angioplasty, CXC chemokines may be targets for preventing stenosis. The expression leukocyte surface chemokine receptors (CCR2/CCR5/CXCR2/CXCR3), as determined by flow cytometry, plasma concentrations monocyte chemoattractant protein (MCP)-1 interferon-inducible (IP)10, enzyme immunoassays, were investigated 55 patients with...

In-stent restenosis (ISR) remains the major limitation of percutaneous coronary intervention (PCI), and mechanism ISR is neointimal growth. Higher serum total bilirubin (TBIL) inhibits inflammatory response proliferation vascular smooth muscle cells; however, relationship between TBIL still unclear. This study aimed to determine whether level associated with after stenting in patients artery disease.This investigated 1076 consecutive who underwent follow-up angiography (average period: 236...

Cell adhesion molecules have been implicated in the of leukocytes to endothelial cells and therefore play a role atherosclerosis, which is frequent cause morbidity mortality patients with coronary artery disease (CAD) or undergoing hemodialysis (HD). The levels expression leukocyte were evaluated CAD HD.The (ie, neutrophil, monocyte lymphocyte) surface CD11a, CD18, intracellular molecule-1 (ICAM-1), very late antigen-4 alpha (VLA-4 alpha) L-selectin was investigated by flow cytometry 20 who...