A5035368639- Cerebrovascular and genetic disorders
- Cell Adhesion Molecules Research
- Genomics and Rare Diseases
- Neurological diseases and metabolism
- Reflective Practices in Education
- Evaluation of Teaching Practices
- COVID-19 and healthcare impacts
- Nutritional Studies and Diet
- Employment and Welfare Studies
- Health disparities and outcomes
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Pneumonia and Respiratory Infections
- Endometrial and Cervical Cancer Treatments
- Fungal and yeast genetics research
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Child Abuse and Trauma
- Education and Critical Thinking Development
- Primary Care and Health Outcomes
- Moyamoya disease diagnosis and treatment
- Child Abuse and Related Trauma
- Romani and Gypsy Studies
- Cardiovascular Health and Risk Factors
- Irish and British Studies
NHS Greater Glasgow and Clyde
2023-2025
University of Glasgow
2024-2025
University of Edinburgh
1990-2023
The Queen's Medical Research Institute
2022
Ludwig-Maximilians-Universität München
2022
Roslin Institute
2022
Health Data Research UK
2022
Institute of Genetics and Cancer
2022
Western General Hospital
2022
LMU Klinikum
2022
Abstract Background The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) may cause resistance of tumour cells to alkylating agents, and is a predictive biomarker in high-grade gliomas treated with temozolomide. Recent EANO guidelines recommend internal validation MGMT methylation cut-offs reporting gray zone values. This study aimed develop method derive from pyrosequencing data. Methods We developed find the optimal using values (CpG sites 72-83) 308 glioblastoma cases...
Nuclear pre-mRNA splicing in Saccharomyces cerevisiae, as higher eukaryotes, occurs large RNA-protein complexes called spliceosomes. The small nuclear RNA components, U1, U2, U4, U5, and U6, have been extensively studied; however, very little is known about the protein components of yeast Here we use antibodies against precursor processing PRP8, a component U5 ribonucleoprotein particle, to detect its association with spliceosomes throughout reaction post-splicing complex containing excised...
AbstractAbstractIntroduction The use of near-peer teaching in medical schools is increasing internationally. Peer observation (POT) a useful and effective method for enhancing experiences quality, but its among student peer teachers not well documented. aim the study was to explore perceptions on value limitations POT.Methods Ten students were trained as observers. Using previously developed model, they observed 27 sessions led by other (observees), with pre- post-observation meeting....
<h3>Background and Objectives</h3> Based on previous case reports disease-based cohorts, a minority of patients with cerebral small vessel disease (cSVD) have monogenic cause, many also manifesting extracerebral phenotypes. We investigated the frequency, penetrance, phenotype associations putative pathogenic variants in cSVD genes UK Biobank (UKB), large population-based study. <h3>Methods</h3> used systematic review literature ClinVar to identify rare <i>CTSA</i>, <i>TREX1</i>,...
To describe the association between socio-economic status and prevalence of key cardiovascular risk factors in people with type 2 diabetes Scotland.A cross-sectional study 264 011 Scotland 2016 identified from population-based register. Socio-economic was defined using quintiles area-based Scottish Index Multiple Deprivation (SIMD) quintile (Q)1 Q5 used to identify most- least-deprived fifths population, respectively. Logistic regression models adjusted for age, sex, health board, history...
Abstract Background Sars-CoV-2, the causative agent of COVID-19, has led to more than 226,000 deaths in UK and multiple risk factors for mortality including age, sex deprivation have been identified. This study aimed identify which individual indicators Scottish Index Multiple Deprivation (SIMD), an area-based index, were predictive mortality. Methods was a prospective cohort anonymised electronic health records 710 consecutive patients hospitalised with Covid-19 disease between March June...
Abstract Background This study aims to explore the association of childhood maltreatment with obesity and type 2 diabetes (T2D) in adulthood, whether is a mediator latter. Methods In retrospective cohort using UK Biobank data, participants recalled maltreatment. Linear regression, logistic Cox proportional hazard models were used investigate associations body mass index (BMI), obesity, T2D, adjusted for sociodemographic factors. Decomposition analysis was examine extent which T2D excess risk...
Abstract Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and absence of diabetes mellitus prior doxycycline treatment (but not time to HAP onset) identified requiring coverage.
Abstract Based on previous case reports and disease-based cohorts, a minority of patients with cerebral small vessel disease (cSVD) have monogenic cause, many also manifesting extra-cerebral phenotypes. We investigated the frequency, penetrance, phenotype associations rare variants in cSVD genes UK Biobank (UKB), large population-based study. used systematic review literature ClinVar to identify putative pathogenic CTSA, TREX1, HTRA1, COL4A1/2 . mapped phenotypes previously attributed these...
Abstract Background Cerebral small vessel disease (cSVD) is an important cause of stroke and vascular dementia. Most cases are multifactorial, but emerging minority have a monogenic cause. While NOTCH3 the best-known gene, several others been reported. We aimed to summarise cerebral phenotypes associated with these more recent cSVD genes. Methods performed systematic review (PROSPERO: CRD42020196720), searching Medline/Embase (conception July 2020) for any language publications describing...
<h3>Background</h3> Health inequalities exist in outcomes of diabetes different socioeconomic groups and these are particularly marked for cardiovascular disease. This study explores the association between status (SES) prevalence risk factors (smoking, body mass index (BMI), glycated haemoglobin (HbA<sub>1C</sub>), blood pressure cholesterol) people with type 2 contemporary Scottish data. <h3>Methods</h3> We performed a cross-sectional Scotland who were alive on 30/6/16 identified from...