A5060861409- Health, Medicine and Society
- Healthcare Systems and Practices
- Psychoanalysis and Psychopathology Research
- Social Sciences and Governance
- Social Policies and Family
- Education, sociology, and vocational training
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- French Urban and Social Studies
- Historical and Scientific Studies
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Cultural Insights and Digital Impacts
- Linguistics and Discourse Analysis
- Monoclonal and Polyclonal Antibodies Research
- Interpreting and Communication in Healthcare
- Salivary Gland Disorders and Functions
- Gallbladder and Bile Duct Disorders
- Blood disorders and treatments
- Colorectal and Anal Carcinomas
- T-cell and B-cell Immunology
- Aging, Elder Care, and Social Issues
- Cancer Genomics and Diagnostics
Université de Strasbourg
2002-2025
Archives Henri-Poincaré - Philosophie et Recherches sur les Sciences et les Technologies
2015-2024
Université de Lorraine
1990-2024
Centre National de la Recherche Scientifique
2018-2023
Hôpitaux Universitaires de Strasbourg
2008-2023
Centre Hospitalier Universitaire de Rennes
2020
Institut de Recherche Interdisciplinaire sur les Enjeux Sociaux
2003-2017
Clinique Pasteur
2008-2015
Centre Hospitalier Régional et Universitaire de Nancy
2015
Hôpital Civil, Strasbourg
1994-2014
To assess outcome after a 2-stage hepatectomy procedure (TSHP) combined with portal vein embolization (PVE) in the treatment of patients unresectable multiple and bilobar colorectal liver metastases (MBCLM).Patients MBCLM are often considered for palliative chemotherapy only, due to too small future remnant (FRL). Recently, right simultaneous left wedge resections previous PVE has been reported curative intent. However, growth metastatic nodules FRL can be more rapid than that nontumoral...
SMI is a previously characterized IgM kappa polyreactive (natural) autoantibody. The variable regions of the heavy and light chains are respectively encoded by nonmutated VH1 gene, designated 51p1, conserved V Humkv325. These genes seem to be over-represented in autoimmune fetal B cell repertoires, frequently expressed malignant cells during certain lymphoid proliferations such as chronic lymphocytic leukemia. Polyreactive natural autoantibodies thought rely mainly on use germ-line...
Objective Patients with Sjögren's syndrome (SS) have an increased risk of developing monoclonal B cell non-Hodgkin's lymphomas (MNHL), which frequently occur in the salivary glands (SG). The transition from benign lymphocyte infiltrate gland that characterizes SS to MNHL is not well understood. Previous sequence analyses expressed variable (V) region genes supported theory surface Ig (sIg) plays important role initial expansion nonmalignant clones and lymphomagenesis. However, antigenic...
In Brief Objective: The objective of this study was to evaluate the short- and long-term outcome after first repeat resection in patients older than 70 years. Summary Background Data: Liver is best treatment for colorectal liver metastases currently increasingly performed elderly patients. benefit these needs be evaluated. Methods: Between 1990 2000, 56 16 resections were 61 Patients identified from a prospective database records reviewed retrospectively. Results: First resulted,...
Background: Fever and inflammatory syndrome of unknown origin pose diagnostic challenges, particularly in elderly patients with atypical presentations. 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) has proven useful these cases, yet its role geriatric populations remains underexplored. This study evaluates the impact 18F-FDG PET/CT on management conditions patients. Methods: A retrospective aged ≥75 years who underwent between 2013 2018 for...
Few data is currently available on neutropenia and agranulocytosis related to drug intake. We report here 203 patients with established idiosyncratic drug-induced agranulocytosis, followed up in a referral centre within university hospital.Data from were retrospectively reviewed. All cases extracted cohort study the Strasbourg University Hospital (Strasbourg, France) RESULTS: : The mean age was 61.6 years old (range: 18-95), gender ratio (F/M) 1.3. Several comorbidities present 63.5%. most...
Rationale: The aim of the present study was to assess stability cryopreserved human hepatocytes over 5 years and explore experimental condition-related variables such as seeding density, culture matrix medium, start duration treatment that could potentially affect quality cultures their response cytochrome P450 (CYP) inducers.Results: 63/125 batches were plateable after thawing. Of those, 17 showed reproducible recovery, viability plateability (less than 5% intra-batch variability) up years....
Delayed Enhancement Pattern in a Localized Fibrous Tumor of the LiverThomas Moser1, Tereza S. Nogueira1, Agnès Neuville2, Sophie Riehm1, Gerlinde Averous2, Jean-Christophe Weber3 and Francis Veillon1Audio Available | Share
We studied the pathogenesis of puffy hand syndrome intravenous drug use. hypothesized that injections high-dose sublingual buprenorphine, instead recommended administration, could play an important role in lymphatic obstruction and destruction.We set up a case-control study substitution centres, recruiting addicts with without hands, respectively. The subjects were asked to answer anonymously questionnaire 40 items comprising social demographic status, history illicit drugs use,...
Objective Silica is an environmental substance strongly linked with autoimmunity. The aim of this study was to assess the prevalence antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), including granulomatosis polyangiitis (GPA), microscopic (MPA), and renal limited vasculitis, in a northeastern region France evaluate whether there geospatial association between localization quarries these AAVs. Methods Potential AAV patients were identified using 3 sources: hospital...
Abstract In colorectal cancer, the molecular alterations that lead to metastasis are not clearly established, probably because of their high genetic complexity. To identify combinations changes involved in tumor progression and metastasis, we focused on chromosome instable (CIN) colon cancers. We compared by allelotyping 33 microsatellites, genomic 38 primary tumors with synchronously resected matched liver metastases (CLM). observed ( i ) number patients at certain loci did differ...
There is evidence that in certain situations the expressed antibody repertoire dominated by small subsets of V gene segments. They include fetal, CD5+, and autoantibody-forming B cells as well low grade cell malignancies. For instance, inside kappa III family approximately 10 members, only 3 (humkv325, 328, Vg) are used recurrently for autoantibody production. However, significance this recurrence difficult to interpret without a clear vision actual normal subjects. To address this, we have...