A5033414011- Hematopoietic Stem Cell Transplantation
- Avian ecology and behavior
- Immune Cell Function and Interaction
- Marine animal studies overview
- Chronic Lymphocytic Leukemia Research
- Polyomavirus and related diseases
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Freshwater macroinvertebrate diversity and ecology
- T-cell and B-cell Immunology
- Prenatal Screening and Diagnostics
- Cytomegalovirus and herpesvirus research
- Cancer therapeutics and mechanisms
- Climate variability and models
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Blood groups and transfusion
- Animal Ecology and Behavior Studies
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Parvovirus B19 Infection Studies
Environment and Climate Change Canada
2016-2023
Mallinckrodt (United States)
2020
Bellicum Pharmaceuticals (United States)
2018-2019
Government of Canada
2018
Amgen (United States)
2010-2015
Genentech
2015
St. Jude Children's Research Hospital
2001-2009
University of Tennessee Health Science Center
2001-2009
Exelixis (United States)
2008-2009
University of Michigan–Ann Arbor
2009
Adenovirus (ADV) infections are associated with significant morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The virus is endemic in the general pediatric population frequently causes severe disease immunocompromised patients, especially children. We report our experience cidofovir (CDV) for treatment of ADV infection 57 HSCT median age 8 years (range 0.5-26).Peripheral blood was prospectively screened weekly on all patients by quantitative real-time PCR first...
Thrombocytopenia in patients with myelodysplastic syndrome (MDS) is associated shortened survival and an increased risk of evolution to acute myeloid leukemia (AML). In this study, the authors evaluated efficacy romiplostim who had thrombocytopenia low-risk/intermediate-1-risk MDS.Patients MDS (N = 250) were randomized 2:1 receive or placebo weekly for 58 weeks.The primary endpoint- number clinically significant bleeding events (CSBEs) per patient-had a hazard ratio romiplostim:placebo 0.83...
Thrombopoietin receptor agonists (TPOra) are the only treatments for immune thrombocytopenia (ITP) which evidence of efficacy and safety from randomized, placebo-controlled trials is available. We sought to determine long-term tolerability TPOra romiplostim, with a particular focus on thrombosis, bleeding, bone marrow (BM) reticulin, neoplasms/haematological malignancies fatal events.
Summary. Natural killer (NK) cell alloreactivity resulting from immunoglobulin‐like receptor (KIR) ligand incompatibility improves outcomes in patients receiving extensively T‐cell‐depleted bone marrow (BM) grafts. Patients with KIR are at risk for donor T‐cell alloreactivity. We investigated the relative significance of NK‐cell and 105 paediatric who received a minimally human leucocyte antigen‐non‐identical BM transplantation. Donor did not improve patient outcome [engraftment,...
Seasonal declines in breeding performance are widespread wild animals, resulting from temporal changes environmental conditions or individual variation. might drive selection for early breeding, with implications other stages of the annual cycle. Alternatively, on phenology nonbreeding could constrain timing season and lead to seasonal reproductive performance. We studied 25 taxa migratory shorebirds (including five subspecies) at 16 arctic sites Russia, Alaska, Canada. investigated four...
The main obstacles to successful haploidentical haematopoietic stem cell transplantation from a mismatched family member donor are delayed immune reconstitution, vulnerability infections and severe graft-versus-host disease (GvHD). We designed reduced-intensity conditioning regimen that excluded total body irradiation anti-thymocyte globulin in order expedite reconstitution after CD3-depleted transplant. This protocol was used treat 22 paediatric patients with refractory haematological...
The Arctic is experiencing rapidly warming conditions, increasing predator abundance, and diminishing population cycles of keystone species such as lemmings. However, it still not known how many animals will respond to a changing climate with altered trophic interactions. We studied clutch size, incubation duration nest survival 17 taxa Arctic‐breeding shorebirds at 16 field sites over 7 years. predicted that physiological benefits higher temperatures earlier snowmelt would increase...
Many Arctic shorebird populations are declining, and quantifying adult survival the effects of anthropogenic factors is a crucial step toward better understanding population dynamics. We used recently developed, spatially explicit Cormack–Jolly–Seber model in Bayesian framework to obtain broad-scale estimates true annual rates for 6 species shorebirds at 9 breeding sites across North American 2010–2014. tested environmental ecological variables, study site, nest fate, sex on each framework,...
Hemorrhagic cystitis (HC) is a well-documented adverse event experienced by patients undergoing hematopoietic stem cell transplantation. When severe, HC causes significant morbidity, leads to renal complications, prolongs hospitalization, increases health-care costs, and occasionally contributes death. We retrospectively studied the medical records of 245 children an initial allogeneic bone marrow transplantation for malignant disease at St. Jude Children's Research Hospital between 1992...
Summary Prospective magnetic resonance imaging (MRI), angiography (MRA), neuropsychological testing and neurological examinations were performed to determine the long‐term effect of successful haematopoietic stem cell transplantation on status nine children with sickle disease. A scoring system for severity brain parenchymal vascular lesions was developed applied. Neurological neuropsychometric tests stable, but MRI MRA studies not. Transient changes occurred early in two patients....
Hemorrhagic cystitis (HC) results in significant morbidity among hematopoietic stem cell transplant (HSCT) recipients. Several potential causes for HC have been postulated, including viral infection, but definitive evidence is lacking, particularly pediatric HSCT patients.Ninety recipients were prospectively tested on a weekly basis adenovirus (ADV) and BK virus (BKV) by quantitative real-time polymerase chain reaction blood urine samples. Results correlated with the occurrence of grade...
Abstract Background Therapy‐related myelodysplastic syndrome (t‐MDS) and acute myeloid leukemia (t‐AML) carry a poor prognosis. We analyzed the results of allogeneic HSCT in 38 children to determine which factors, if any, affected outcome. Procedure The effects demographic, donor, disease‐related factors were their on overall disease‐free survival (OS, DFS), relapse, non‐relapse mortality (NRM). Results OS DFS for t‐AML t‐MDS similar. Three‐year EFS same (15.4 ± 5.8%) 3‐year NRM was 59.6...
Rabbit antithymocyte globulin (rATG; Thymoglobulin) is currently used to prevent or treat graft-versus-host disease (GVHD) during hematopoietic stem cell transplantation (HSCT). The dose and schedule of rATG as part the preparative regimen for unrelated donor (URD) bone marrow (BMT) have not been optimized in pediatric patients. We conducted a prospective study 13 patients with hematologic malignancies undergoing URD BMT at St. Jude Children's Research Hospital from October 2003 March 2005,...
Abstract Conservation status and management priorities are often informed by population trends. Trend estimates can be derived from surveys or models, but both methods associated with sources of uncertainty. Many Arctic-breeding shorebirds thought to declining based on migration and/or overwintering surveys, data lacking estimate the trends some shorebird species. In addition, for most species, little is known about stage(s) at which bottlenecks occur, such as breeding vs. nonbreeding...
Management of pulmonary complications after hematopoietic stem cell transplantation (HSCT) often includes bronchoalveolar lavage (BAL), but the diagnostic yield BAL remains unclear in pediatric HSCT patients. We reviewed records 78 allogeneic and 11 autologous transplant recipients who underwent at St. Jude Children's Research Hospital (1990-2002). analyzed donor recipient information, clinical variables, adverse events during bronchoscopy, outcome, medical management time procedure to...
Bone marrow transplantation is associated with numerous pulmonary complications, which may manifest as nodules. We studied 33 bone transplant (BMT) recipients in whom nodular lesions (PNLs) developed during a 5-year period and who underwent open lung biopsy (OLB) for diagnosis. Of patients PNL, 15 (45%) had cytolytic thrombi (PCT), recently described condition characterized histologically by occlusive vascular hemorrhagic infarcts clinically favorable outcome. Clinical symptoms radiologic...
We describe long-term disease-free survival (DFS) after unrelated donor bone marrow transplantation (BMT) for myelodysplastic syndrome (MDS) in 118 patients aged ≤18 years. Forty-six had refractory cytopenia (RC), 55 anemia with excess blasts (RAEB), and 17 transformation (RAEB-t). Transplant-related mortality was higher mismatched BMT (relative risk [RR] 3.29, P = .002). Disease recurrence more likely advanced stages of MDS at the time BMT: RAEB (RR 6.50, .01) or RAEB-t 11.00, .004)....
Romiplostim is recommended for the second- and third-line treatment of primary immune thrombocytopenia (ITP). We conducted a large, single-arm study (clinicaltrials.gov; NCT00508820) with broad entry criteria to evaluate safety romiplostim in adult ITP. Patients (n = 407) ITP lasting 0.03-57.14 years low platelet counts (median 14.0 × 10<sup>9</sup>/l) or uncontrolled bleeding received up 4 years. The rates treatment-related, serious adverse events, hemorrhage thromboembolic...
All allogeneic (allo) and autologous (auto) hematopoietic stem cell transplantation (HSCT) recipients at St. Jude Children's Research Hospital undergo pre-HSCT computed tomography (CT) of the sinuses, chest, abdomen because they are significant risk for opportunistic infections. We studied whether this extensive routine imaging is warranted to detect infection despite additional radiation exposure. reviewed medical records all children receiving allo- auto-HSCT in 2004 2005. Of 184 eligible...