A5066959265- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Polyomavirus and related diseases
- HIV Research and Treatment
- Colorectal and Anal Carcinomas
- Chronic Lymphocytic Leukemia Research
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Platelet Disorders and Treatments
- Cancer Diagnosis and Treatment
- Blood groups and transfusion
- Immune Cell Function and Interaction
- Cervical Cancer and HPV Research
- Histiocytic Disorders and Treatments
- Poxvirus research and outbreaks
- Head and Neck Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Disorders and Syndromes
- Diabetes and associated disorders
- Hepatitis C virus research
- interferon and immune responses
- CNS Lymphoma Diagnosis and Treatment
HOPE Clinic
2025
Emory and Henry College
2018-2025
Emory University
2011-2024
Grady Memorial Hospital
2013-2024
AIDS Clinical Trials Group
2013-2024
Grady Health System
2014-2023
Winship Cancer Institute
2020
Centers for Disease Control and Prevention
2013
AID Atlanta
2011
New York University
1998
Objective: To identify risk factors for Kaposi's sarcoma (KS) among men seropositive both human herpesvirus 8 (HHV-8) and HIV. Design: Cross-sectional study of 91 HHV-8 seropositive, HIV who have sex with (57 KS), 70 controls at lower KS. Methods: Patients received clinical evaluations. Blood, oral fluids, semen, rectal brush, swab, urine were collected, tests performed. Results: Men KS more likely to DNA in peripheral blood mononuclear cells (PBMC) than without [35.1 versus 5.9%, odds ratio...
We present the largest longitudinal study to date that examines association between Kaposi's Sarcoma (KS) disease progression and presence viral load of human herpesvirus 8 (HHV-8).Ninety-six men were enrolled at HIV clinics in Atlanta, Georgia, who had KS (n = 47) or without but seropositive for HHV-8. Visits occurred 6-month intervals 2 years which patient's status was evaluated oral fluid blood collected quantification HHV-8 DNA antibodies.The more common (P < 0.001) higher with...
Abstract BACKGROUND: Lung cancer is the leading cause of death among non‐acquired immunodeficiency syndrome (AIDS)‐defining malignancies. Because highly active antiretroviral therapy (HAART) has improved survival patients with human virus (HIV), authors evaluated lung outcomes in HAART era. METHODS: HIV‐positive who were diagnosed at authors' institution during era (1995‐2008) analyzed. Patient charts reviewed for clinical and laboratory data. The CD4 count diagnosis was treated as a...
J Oral Pathol Med (2012) 41 : 288–291 Background: human papillomavirus (HPV) is associated with several health complications especially in combination HIV infections. Screening may be useful, but methodologies and results have varied widely previous studies. We conducted a pilot study an HIV‐positive population to evaluate HPV detection four different oral sample types. Methods: Upon enrollment, oral‐rinse (OR) was collected 10 ml saline. Additional samples of the buccal mucosa, tonsils,...
To study the natural history and pathogenesis of human herpesvirus 8 (HHV-8) infection in HHV-8-seropositive, immunosuppressed men.Longitudinal 87 HHV-8- HIV-seropositive men [42 with Kaposi's sarcoma (KS)] during four visits over a 2 month period.: Patients provided oral fluid blood. HHV-8 antibody titers were measured peptide-based enzyme-linked immunosorbent assays (ELISA) for ORF65 K8.1; DNA was detected polymerase chain reaction ELISA.HHV-8 present or peripheral blood mononuclear cells...
Background Human herpesvirus 8 ( HHV ‐8) is likely transmitted through blood transfusion in high‐prevalence areas. The efficacy of leukoreduction filtration for reducing ‐8 has not been reported. Study Design and Methods Blood was drawn from 45 human immunodeficiency virus–positive men either with Kaposi's sarcoma KS ; n = 21) or without (n 24) subject to filtration. viral load measured plasma before after Results Twelve subjects, all , had detectable viremia loads 10 2 5 copies/ mL (mean, 3...
Recent studies have identified durable responses with the use of immune checkpoint inhibitors in patients mismatch repair–deficient (MMR-D)/microsatellite instability–high (MSI-H) metastatic colorectal cancer (CRC). The dramatic improvement clinical outcomes led to US Food and Drug Administration approval pembrolizumab, nivolumab, nivolumab combination ipilimumab MSI-H/MMR-D CRC who previously experienced progression on cytotoxic therapies. In trials investigating these agents,...
Objective: Kaposi's sarcoma (KS) is a neoplasm strongly associated with HIV-1 infection and marked by leukocytic infiltration. The infiltrating leukocytes are possible source of inflammatory cytokines, human herpesvirus 8 (HHV8) the transactivator protein Tat. This study examines whether Tat directly induces expression cellular adhesion molecules cytokines in KS cells this induction differs kinetics magnitude from tumour necrosis factor (TNF) α. Design method: Changes gene response to...
To explore the diagnosis of hematolymphoid malignancies liver (hepatic lymphoma [HeL]) by image-guided fine-needle aspiration (FNA), which can often be difficult due to a low index suspicion and nonspecific patient presentations, especially in rare cases where is only site disease (primary HeL [PHeL]). Understanding clinical setting such lesions arise, as well cytomorphologic findings, may assist cytopathologists making an accurate triaging samples for ancillary studies.In this retrospective...
Objectives The aim of the study was to evaluate long‐term changes in lipids and assess other coronary heart disease (CHD) risk factors highly experienced AIDS patients with immune reconstitution, examine their association antiretroviral therapy (ART). Methods We evaluated 433 prior severe immunosuppression ART‐based followed a multicentre prospective observational between 2000 2006. estimated prevalence at entry hypercholesterolaemia metabolic syndrome, 10‐year CHD risks. Trends total...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial evolution occurred, including the emergence of mutations associated cocktail received.
The national incidence of epidemic Kaposi sarcoma (KS) has decreased dramatically since the availability combined antiretroviral therapy. Despite trends, we continue to see admissions for KS. Electronic medical records were queried identify patients with HIV who admitted active KS between 2010 and 2013 reviewed determine patient characteristics factors affecting survival. Data collected from all hospital until death or May 1, 2015. Kaplan–Meier survival analysis log-rank tests used test...
Abstract The 2022 mpox outbreak primarily involved sexual transmission among men who have sex with and disproportionately affected persons human immunodeficiency virus (HIV). We examined viral dynamics clinical features in a cohort evaluated for infection at comprehensive HIV clinic Atlanta, Georgia. Viral DNA was found 8 oropharyngeal 5 anorectal specimens 10 cases confirmed by lesion swab polymerase chain reaction. Within-participant anatomic site of lowest cycle threshold (Ct) value...