A5079355831- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- Mobile Health and mHealth Applications
- Respiratory viral infections research
- Telemedicine and Telehealth Implementation
- Speech Recognition and Synthesis
- Music and Audio Processing
- Cardiovascular Health and Risk Factors
- Advanced biosensing and bioanalysis techniques
- Poxvirus research and outbreaks
- Herpesvirus Infections and Treatments
- Maternal and fetal healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Bacillus and Francisella bacterial research
- CRISPR and Genetic Engineering
- Obesity, Physical Activity, Diet
- Maternal and Perinatal Health Interventions
- Maternal Mental Health During Pregnancy and Postpartum
- Artificial Intelligence in Healthcare and Education
- Ethics in Clinical Research
- Adolescent and Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Mobile Crowdsensing and Crowdsourcing
Georgia Research Alliance
2024
Georgia Clinical and Translational Science Alliance
2022-2024
Emory University
2021-2024
Background Artificial intelligence chatbots such as ChatGPT (OpenAI) have garnered excitement about their potential for delegating writing tasks ordinarily performed by humans. Many of these (eg, recommendation letters) social and professional ramifications, making the biases in ChatGPT’s underlying language model a serious concern. Objective Three preregistered studies used text analysis program Linguistic Inquiry Word Count to investigate gender bias letters written human-use sessions...
The effects of mutations in continuously emerging variants SARS-CoV-2 are a major concern for the performance rapid antigen tests. To evaluate impact on 17 antibodies used 11 commercially available tests with emergency use authorization, we measured antibody binding all possible Nucleocapsid point using mammalian surface-display platform and deep mutational scanning. results provide complete map antibodies' epitopes their susceptibility to escape. Our data predict no vulnerabilities...
Rapid antigen tests (RATs) have become an invaluable tool for combating the COVID-19 pandemic. However, concerns been raised regarding ability of existing RATs to effectively detect emerging SARS-CoV-2 variants. We compared performance 10 commercially available, emergency use authorized against Delta and Omicron variants using both individual patient serially diluted pooled clinical samples. The exhibited lower sensitivity samples when PCR cycle threshold (C
This article reports on the validation of Fabla, a researcher-developed and university-hostedsmartphone app that facilitates naturalistic secure collection participants’ spokenresponses to researcher questions. Fabla was developed meet need for tools (a) collectlongitudinal qualitative data (b) capture speech biomarkers from naturalenvironments. study put its first empirical test using repeated-measuresexperimental design in which participants (n=87) completed one-week voice daily diary via...
This article reports on the validation of Fabla, a researcher-developed and university-hostedsmartphone app that facilitates naturalistic secure collection participants’ spokenresponses to researcher questions. Fabla was developed meet need for tools (a) collectlongitudinal qualitative data (b) capture speech biomarkers from naturalenvironments. study put its first empirical test using repeated-measuresexperimental design in which participants (n=87) completed one-week voice daily diary via...
This article reports on the validation of Fabla, a researcher-developed and university-hostedsmartphone app that facilitates naturalistic secure collection participants’ spokenresponses to researcher questions. Fabla was developed meet need for tools (a) collectlongitudinal qualitative data (b) capture speech biomarkers from naturalenvironments. study put its first empirical test using repeated-measuresexperimental design in which participants (n=87) completed one-week voice daily diary via...
Upper respiratory samples for SARS-CoV-2 detection include the gold standard nasopharyngeal (NP) swab, and mid-turbinate (MT) nasal swabs, oropharyngeal (OP) saliva. Following emergence of omicron (B.1.1.529) variant, limited preliminary data suggest that OP swabs or saliva may be more sensitive than highlighting need to understand differences in viral load across different sites.MT, OP, were collected from symptomatic individuals presenting evaluation Atlanta, GA, January 2022. Longitudinal...
As the emergence of SARS-CoV-2 variants brings global pandemic to new levels, performance current rapid antigen tests against concern and interest (VOC/I) is significant public health concern. Here, we report assessment Abbot BinaxNOW COVID-19 Antigen Self-Test. Using genetically sequenced remnant clinical samples collected from individuals positive for SARS-CoV-2, assessed that currently pose threats. We measured limit detection various VOC/I in a blinded manner. successfully detected...
Abstract With today’s pace of rapid technological advancement, many patient issues in modern medicine are increasingly solvable by mobile app solutions, which also have the potential to transform how clinical research is conducted. However, critical challenges development process impede bringing these translational technologies patients, caused large part lack knowledge among clinicians and biomedical researchers “what it takes” design, develop, maintain a successful medical app. Indeed,...
Rapid Antigen Tests (RAT) have become an invaluable tool for combating the COVID-19 pandemic. However, concerns been raised regarding ability of existing RATs to effectively detect emerging SARS-CoV-2 variants. We compared performance eight commercially available, emergency use authorized against Delta and Omicron variants using individual patient serially diluted pooled clinical samples. The exhibited lower sensitivity samples when PCR Cycle threshold (C
Consumer health wearables—commercially available tracking technologies such as smartwatches, fitness trackers, and wearable sensors coupled to smartphones—have provoked a paradigm shift in how people approach their health. One fifth of Americans use on regular basis.1Bayoumy K. Gaber M. Elshafeey A. et al.Smart devices cardiovascular care: where we are move forward.Nat Rev Cardiol. 2021; 18: 581-599Crossref PubMed Scopus (208) Google Scholar These recognized for promises lower costs save...
Limited data highlight the need to understand differences in SARS-CoV-2 omicron (B.1.1.529) variant viral load between gold standard nasopharyngeal (NP) swab, mid-turbinate (MT)/anterior nasal swabs, oropharyngeal (OP) and saliva. MT, OP, saliva samples from symptomatic individuals Atlanta, GA, January 2022 longitudinal a small familial cohort were tested by both RT-PCR ultrasensitive antigen assays. Higher concentrations nares observed cohort, but dominant sample type was not found among 39...
Background The physical, paper-based Georgia TB Reference Guide has served as the clinical reference handbook on tuberculosis (TB) diagnostic and treatment guidelines for state of in United States. Supported by Department Public Health, production 112-page palm-sized booklet was previously led a team Georgia-based experts at Emory University printed every three-five years with updates to management consult contact information. However, costs associated editorial printing combined delays...
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Goal:</i> Monitoring the genetic diversity and emerging mutations of SARS-CoV-2 is crucial for understanding evolution virus assuring performance diagnostic tests, vaccines, therapies against COVID-19. still adapting to humans and, as illustrated by B.1.1.7 (Alpha) B.1.617.2 (Delta), lineage dynamics are fluid, strain prevalence may change radically in a matter months. The National Institutes...
Widespread use of over-the-counter rapid diagnostic tests for SARS-CoV-2 has led to a decrease in availability clinical samples viral genomic surveillance. As an alternative sample source, we evaluated RNA isolated from BinaxNOW swabs stored at ambient temperature rRT-PCR and full genome sequencing. 81 103 (78.6%) yielded detectable RNA, 46 57 (80.7 %) complete sequences. Our results illustrate that extracted used Binax test provides important opportunity improving surveillance, evaluating...
The motivation for this work was the need to establish a predefined cutoff based on genome copies per ml (GE/ml) rather than Ct, which can vary depending laboratory and assay used. A GE/ml-based threshold necessary define what constituted 'low positives" samples that were included in data sets submitted FDA emergency use approval SARS-CoV-2 antigen tests.SARS-CoV-2, causal agent of global COVID-19 pandemic, made its appearance at end 2019 is still circulating population. pandemic led an...
Abstract Background The global spread of Mpox in 2022 largely affected men who have sex with and exposures via the oropharynx anorectum are thought to contribute sexual transmission. New molecular platforms including point-of-care assays for detection DNA from cutaneous lesion samples received emergency use authorization United States but these technologies not validated other sample types, oropharyngeal or anorectal swabs. Methods Anorectal, swabs were initially collected frozen dry at -80C...
Abstract The 2022 mpox outbreak primarily involved sexual transmission among men who have sex with and disproportionately affected persons human immunodeficiency virus (HIV). We examined viral dynamics clinical features in a cohort evaluated for infection at comprehensive HIV clinic Atlanta, Georgia. Viral DNA was found 8 oropharyngeal 5 anorectal specimens 10 cases confirmed by lesion swab polymerase chain reaction. Within-participant anatomic site of lowest cycle threshold (Ct) value...
Abstract Genomic epidemiology offers important insight into the transmission and evolution of respiratory viruses. We used metagenomic sequencing from negative SARS-CoV-2 antigen tests to identify a wide range viruses generate full genome sequences, offering streamlined mechanism for broad virus genomic surveillance.