A5089702849- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Trace Elements in Health
- Phytase and its Applications
- Animal Genetics and Reproduction
- Neuroinflammation and Neurodegeneration Mechanisms
- Folate and B Vitamins Research
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Effects and risks of endocrine disrupting chemicals
- Healthcare and Environmental Waste Management
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- Barrier Structure and Function Studies
- Metabolomics and Mass Spectrometry Studies
- Nanoparticles: synthesis and applications
- Neurological Disease Mechanisms and Treatments
- Fatty Acid Research and Health
- Ferroptosis and cancer prognosis
- Heavy Metal Exposure and Toxicity
- Genetically Modified Organisms Research
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Pregnancy and preeclampsia studies
State Key Laboratory of Medical Neurobiology
2022-2024
Fudan University
2022-2024
China National Center for Food Safety Risk Assessment
2020-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2021
Nanjing Medical University
2020
Second Military Medical University
2017
Macrophage polarization is mainly steered by metabolic reprogramming in the tissue microenvironment, thus leading to distinct outcomes of various diseases. However, role lipid metabolism regulation macrophage alternative activation incompletely understood. Using human THP-1 and mouse bone marrow derived models, we revealed a pivotal for arachidonic acid determining phenotype M2 macrophages. We demonstrated that was inhibited acid, but inversely facilitated its metabolite prostaglandin E2...
Blood–brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key, mainly deleterious role in pathophysiology of ischemic stroke. Neddylation is ubiquitylation-like pathway that critical various cellular functions by conjugating neuronal precursor cell-expressed developmentally down-regulated protein 8 (NEDD8) to target proteins. However, roles neddylation stroke remain elusive. Here, we report NEDD8 conjugation increased during acute phase after was present intravascular...
BACKGROUND: Ischemic stroke is often accompanied by oxidative stress and inflammatory response, both of which work synergistically to exacerbate the disruption blood-brain barrier ischemic brain injury. ALK (anaplastic lymphoma kinase), a cancer-associated receptor tyrosine kinase, was found play role in inflammation. In this study, we investigated inhibition murine model stroke. METHODS: Focal cerebral ischemia induced temporary occlusion right middle artery mice with filament. The...
Folic acid, as one of the essential nutrients, plays a crucial role in human body. Recent researches showed that supplementation folic acid during pregnancy could prevent various birth defects, and many countries around world having implemented policies fortification. However, there are epidemiological evidences excess supplement may not only fail to exert preventive effects on diseases, but also be counter productive. Therefore, recent focusing correlation maternal level growth development...
Abstract Macrophages polarization is mainly controlled by metabolic reprogramming in microenvironment, thus leading to distinct outcomes of various diseases. However, the role lipid metabolism regulation macrophage alternative activation incompletely understood. Using human THP-1 and mouse bone marrow derived macrophages models, we revealed a pivotal for arachidonic acid controlling M1 M2 macrophages. We demonstrated that was inhibited acid, but inversely facilitated its metabolite...
Abstract Background Acute hypoxic-ischemic brain damage (HIBD) occurs not only in newborns but also adults. It is associated with series of cellular and biochemical pathways that lead to neuronal injury. N-3 polyunsaturated fatty acids (PUFAs) have been reported improve neuron functions via G protein-coupled receptor 120 signal pathway cells or exogenous supplementation. Possible protective targets underlying mechanisms high proportion n-3/n-6 PUFAs contained the brains mfat-1 transgenic...