A5008243956- Liver Diseases and Immunity
- Liver Disease Diagnosis and Treatment
- Pediatric Pain Management Techniques
- Family and Patient Care in Intensive Care Units
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Pain Management and Opioid Use
- Infant Development and Preterm Care
- Gallbladder and Bile Duct Disorders
- Healthcare Systems and Practices
- Health, Medicine and Society
- Drug Transport and Resistance Mechanisms
- Geriatric Care and Nursing Homes
- European Socioeconomic and Political Studies
- Anesthesia and Pain Management
- Acute Ischemic Stroke Management
- Organ Transplantation Techniques and Outcomes
- Social Policies and Family
- Intracerebral and Subarachnoid Hemorrhage Research
- Celiac Disease Research and Management
- Simulation-Based Education in Healthcare
- Systemic Lupus Erythematosus Research
- Social Sciences and Governance
- Palliative Care and End-of-Life Issues
- European history and politics
Centre Hospitalier de l’Université de Montréal
2013-2025
Université de Montréal
2012-2025
University of Illinois Chicago
2014-2024
Université Paris Nanterre
2021-2023
Centre d’histoire de Sciences Po
2021-2023
Institut de recherches économiques et sociales
2010-2023
Hôpital Saint-Luc
2002-2021
Centre d’histoire des sociétés Médiévales et Modernes
2021
Debiopharm (Switzerland)
2020
National Institute of Nursing Research
2019
Primary biliary cholangitis (formerly called primary cirrhosis) can progress to cirrhosis and death despite ursodiol therapy. Alkaline phosphatase bilirubin levels correlate with the risk of liver transplantation or death. Obeticholic acid, a farnesoid X receptor agonist, has shown potential benefit in patients this disease.In 12-month, double-blind, placebo-controlled, phase 3 trial, we randomly assigned 217 who had an inadequate response found side effects unacceptable receive obeticholic...
We evaluated the efficacy and safety of obeticholic acid (OCA, α-ethylchenodeoxycholic acid) in a randomized controlled trial patients with primary biliary cirrhosis who had an inadequate response to ursodeoxycholic therapy.We performed double-blind study 165 (95% women) levels alkaline phosphatase (ALP) 1.5- 10-fold upper limit normal. Patients were randomly assigned groups given 10 mg, 25 or 50 mg doses OCA placebo, once daily for 3 months. maintained their existing dose throughout study....
Obeticholic acid (OCA), a potent farnesoid X receptor agonist, was studied as monotherapy in an international, randomized, double‐blind, placebo‐controlled phase 2 study patients with primary biliary cholangitis who were then followed for up to 6 years. The goals of the assess benefit OCA absence ursodeoxycholic acid, which is relevant are intolerant and at higher risk disease progression. Patients randomized dosed placebo (n = 23), 10 mg 20), or 50 16) given once daily 3 months (1 patient...
Treatment outcomes for people living with autoimmune hepatitis (AIH) are limited by a lack of specific therapies, as well well-validated prognostic tools and clinical trial endpoints. We sought to identify predictors outcome AIH.
Self-report is often represented as "the gold standard" in assessment of pain intensity children. We evaluate arguments for and against this claim consider its implications management.Those the support proposition argue that, when children are able to self-report, treatment decisions should be made based on these scores line with current evidence-based recommendations. Pain a subjective phenomenon can assessed only via self-report. Treating self-report standard valid way health care...
Background: Few nutrition education strategies using technology have been developed and evaluated for patients with cirrhosis. This study aims to describe the receptivity of these technology-based education, specifically assessing their interest, preferences, Internet attitudes, technological skills computers mobile devices, factors associated interest in such educational approaches. Methods: A cross-sectional was conducted among Questionnaires included participant characteristics,...
To describe nurses' knowledge and attitudes about relieving children's pain, perceived barriers to optimal pain management, analgesics administered by nurses in relation levels of pain.Data were collected from 67 132 children their care. Outcomes measured with The Nurses' Knowledge Attitudes Survey Regarding Pain, the Perceived Barriers Optimal Pain Management for Children Survey, calculations ordered analgesia nurse, Oucher scale intensity pain.Most demonstrated positive but lacked...
The Theory of Unpleasant Symptoms was developed to enhance understanding relationships among multiple symptoms and symptom experiences. Although the theory has been used guide research, no formal critique published since 2000. This article comprehensively analyzes evaluates using Fawcett DeSanto-Madeya's framework. its semantic clarity, structural consistency, parsimony could be improved, demonstrates good social theoretical significance, testability, empirical pragmatic adequacy....
Patients with primary biliary cholangitis (PBC) incomplete response to ursodeoxycholic acid are at risk of disease progression and need additional therapy. Obeticholic (OCA) was approved in Canada May 2017, but its effectiveness a real‐world setting has not been described. We sought describe our experience OCA Canadian cohort. OCA‐naive patients treated two centers were included. Clinical biochemical data collected initiation during follow‐up. Primary outcomes changes serum alkaline...
Afabicin (formerly Debio 1450, AFN-1720) is a prodrug of afabicin desphosphono, an enoyl-acyl carrier protein reductase (FabI) inhibitor, and first-in-class antibiotic with novel mode action to specifically target fatty acid synthesis in Staphylococcus spp. The efficacy, safety, tolerability were compared those vancomycin/linezolid the treatment acute bacterial skin structure infections (ABSSSI) due staphylococci this multicenter, parallel-group, double-blind, double-dummy phase 2 study.
Summary Background A human betaretrovirus has been characterized from patients with primary biliary cirrhosis (PBC). Uncontrolled studies using combination anti‐retroviral therapy have reported significant biochemical and histological improvement. Aim To conduct a double‐blind, randomized controlled trial as proof of principal to link infection PBC. Methods Fifty‐nine an alkaline phosphatase level >1.5 upper limits normal stabilized on ursodeoxycholic acid were either 300 mg zidovudine...
Abstract Purpose. We tested home pain management for children effects on intensity, analgesics administered, satisfaction, and use of healthcare services over 3 post‐discharge days. Design Methods. In this quasi‐experimental study with 108 their parents, we used the numeric rating scale or Faces Pain Scale‐Revised, calculated percentages asked questions about expectations, services. Between‐group differences were t ‐tests analysis variance. Results: After children, reported moderate pain,...