A5005269237- Cardiac Ischemia and Reperfusion
- Heat shock proteins research
- Signaling Pathways in Disease
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Anesthesia and Neurotoxicity Research
- Neuroscience of respiration and sleep
- Cardiovascular Disease and Adiposity
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Biomarkers in Disease Mechanisms
- Peptidase Inhibition and Analysis
- Anesthesia and Pain Management
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Energy and Environment Impacts
- Cardiac Fibrosis and Remodeling
Nanjing Medical University
2021-2024
Jiangsu Province Hospital
2022-2024
Loma Linda University
2023-2024
Myocardial ischemia/reperfusion (MI/R) injury is a major cause of adverse outcomes revascularization following myocardial infarction. Anaerobic glycolysis during ischemia well-studied, but the role aerobic early phase reperfusion incompletely understood. Lactylation Histone H3 (H3) an epigenetic indicator glycolytic switch. Heat shock protein A12A (HSPA12A) atypic member HSP70 family. In present study, we report that ischemia, HSPA12A was downregulated and flux decreased in cardiomyocytes....
Cardiac fibrosis is the main driver for adverse remodeling and progressive functional decline in nearly all types of heart disease including myocardial infarction (MI). The activation cardiac fibroblasts (CF) into myofibroblasts responsible fibrosis. Unfortunately, no ideal approach controlling CF currently exists. This study investigated role Heat shock protein 12A (HSPA12A), an atypical member HSP70 family, MI-induced Primary Hspa12a knockout mice were used experiments. was indicated by...
Cigarette smoking/nicotine exposure in pregnancy shows an increased risk of hypertension offspring, but the mechanisms are unclear. This study tested hypothesis that m6A RNA hypomethylation epigenetically regulates vascular NOX (NADPH oxidase) and reactive oxygen species production, contributing to fetal programming a hypertensive phenotype nicotine-exposed offspring.
Angiogenesis plays a critical role in wound healing postmyocardial infarction (MI). However, there is still lack of ideal angiogenic therapeutics for rescuing ischemic hearts clinically, suggesting that more understanding regarding angiogenesis regulation urgently needed. Heat shock protein A12A (HSPA12A) an atypical member the HSP70 family. Here, we demonstrated HSPA12A was upregulated during endothelial tube formation, characteristic vitro angiogenesis. Intriguingly, overexpression...