A5058846707- Multiple Myeloma Research and Treatments
- Catalysis and Hydrodesulfurization Studies
- Catalysts for Methane Reforming
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Catalytic Processes in Materials Science
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- CO2 Reduction Techniques and Catalysts
- Crystallization and Solubility Studies
- Gestational Diabetes Research and Management
- Thermal Radiation and Cooling Technologies
- Calcium Carbonate Crystallization and Inhibition
- Clusterin in disease pathology
- Quinazolinone synthesis and applications
- Fungal Plant Pathogen Control
- Membrane Separation Technologies
- Solar-Powered Water Purification Methods
- Cancer Mechanisms and Therapy
- Solar Thermal and Photovoltaic Systems
- Wastewater Treatment and Nitrogen Removal
- Water Treatment and Disinfection
- Ferroptosis and cancer prognosis
Central South University
2019-2025
Third Xiangya Hospital
2019-2025
Henan Polytechnic University
2022-2024
Nanjing Tech University
2023
Loma Linda University
2023
Yancheng Institute of Technology
2023
Hubei University of Chinese Medicine
2018
Purpose: Circular RNA (circRNA) is a key regulatory factor in the development and progression of human tumors. However, working mechanism clinical significance most circRNAs remain unknown cancers, including multiple myeloma (MM). Patients Methods: This study employs high-throughput circRNA microarray with bioinformatics to identify differentially expressed patients MM. The hsa_circ_0007841 expressions were observed MM tissues 86 patients. Drug-resistant cell lines pathological features also...
Background Multiple myeloma (MM) is a hematological malignancy with the proliferation of malignant plasma cells. Numerous studies have highlighted critical role ferroptosis in MM. However, how to use ferroptosis-related genes (FRGs) for prognostic prediction and treatment guidance MM remains unknown.
Abstract Clinical outcomes of patients with multiple myeloma (MM) have almost doubled the overall survival over last decade owing to use proteasome inhibitor such as bortezomib (BTZ). However, some MM develop primary resistance BTZ, whereas others after treatment. In this study, we investigated relationships between BTZ and dysfunction long non-coding RNAs (lncRNAs) in MM. Bone marrow samples were collected from healthy donors for lncRNA microarray analyses. To investigate functions...
Cigarette smoking/nicotine exposure in pregnancy shows an increased risk of hypertension offspring, but the mechanisms are unclear. This study tested hypothesis that m6A RNA hypomethylation epigenetically regulates vascular NOX (NADPH oxidase) and reactive oxygen species production, contributing to fetal programming a hypertensive phenotype nicotine-exposed offspring.
Studies have shown that bortezomib resistance in multiple myeloma (MM) is mediated by the abnormalities of various molecules and microenvironments. Exploring these mechanisms will improve therapeutic efficacy bortezomib. In this study, bone marrow tissues from three patients with MM, both sensitive resistant to bortezomib, were collected for circRNA high-throughput sequencing analysis. The relationship between circ_0000337, miR-98-5p, target gene DNA2 was analyzed luciferase detection...
Multiple myeloma (MM) is a malignant and incurable disease. Chemotherapy currently the primary treatment option for MM. However, chemotherapeutic drugs can interrupt because of serious side effects. Therefore, development novel therapeutics MM essential. In this study, we designed constructed an innovative nanoparticle-based drug delivery system, P-R@Ni3P-BTZ, investigated its feasibility, effectiveness, safety both in vitro vivo. P-R@Ni3P-BTZ nanocomposite that consists two parts: (1)...
Aim: To investigate the prognostic value of lncRNA NR_046683 in multiple myeloma (MM). Methods: High-throughput array was combined with bioinformatics techniques to screen differentially expressed MM. qRT-PCR adopted determine expression target lncRNAs MM patients and controls. Results: It found for first time that is closely related prognosis also detected tumor cell lines KM3, U266, especially drug-resistant KM3/BTZ MM1R. The differed significantly different subtypes staging. Moreover,...
Evodiamine (Evo) is one of the main bioactive components derived from drying mature fruit genus Evodia rutaecarpa (Juss.) Benth. Although Evo has shown its anti-cancer activity in several cancers, effects on multiple myeloma (MM) remain unknown. In this study, we aim to investigate cytotoxic role MM cells.CCK-8 assay, apoptotic cell analysis, xenografted mice model, caspase assay and mitochondrial membrane potential were performed.We found that selectively inhibits proliferation increases...
The chemical transformation of carbon dioxide (CO2) not only reduces the amount emitted into Earth’s atmosphere by humans, but also produces compounds that can be used as precursors for and fuel production. Herein, a selective catalytic conversion to methanol is achieved bifunctional molybdenum disulfide catalyst (MoS2) with magnesium oxide nickel potassium promoters. Molybdenum prepared supercritical ethanol method has large specific surface area presents good performance high selectivity...
The extracellular polymeric substance (EPS) plays a key factor in biofilm formation. However, the research on importance of each EPS fraction is mainly concentrated activated sludge field. In this study, biofilms were cultivated under different hydrodynamic conditions indoor flumes, and important regulatory effects dissolved (SB-EPS), loosely bound (LB-EPS), tightly (TB-EPS) formation investigated. results indicated that ratios soluble (S-EPS), 27:74:108 turbulent flow, 38:48:71 transitional...
The hypercoagulable state is a hallmark for patients with multiple myeloma (MM) and associated disease progression. Activated platelets secrete exosomes promote solid tumor growth. However, the role of platelet-derived in MM not fully clear. We aim to study underlying mechanism how cell Flow cytometry, Western blot, proteome analysis, co-immunoprecipitation, immunofluorescence staining, NOD/SCID mouse subcutaneous transplantation model were performed investigate exosomal LRG1 on Peripheral...
Abstract Background: Multiple myeloma (MM) is a malignant and incurable disease. Currently, chemotherapy the primary approach for treatment of MM. Bortezomib (BTZ) breakthrough drug MM, significantly improving patient survival. However, BTZ can interrupt due to its serious side effects. Therefore, developing novel therapeutics MM essential. Herein, an innovative nanoparticle-based delivery system P-R@Ni 3 P-BTZ designed constructed treat The present study investigated feasibility,...
Bamboo lignin, the principal constituent of non-wood pulping black liquor, is ecologically and environmentally harmful due to its complex molecular structure stability. In addition, syngas-based synthesis higher alcohols a desired industrial application, alleviating dependency on petroleum resources. However, developing highly efficient catalysts with high space-time yield selectivity towards remains challenging. Herein, for first time, taking into account permeable bamboo lignin in...
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