A5102688822- RNA modifications and cancer
- RNA Research and Splicing
- DNA Repair Mechanisms
- Clusterin in disease pathology
Third Xiangya Hospital
2024
Central South University
2024
Fudan University
2024
Abstract Transcription-coupled repair (TCR) is the major pathway to remove transcription-blocking lesions. Although discovered for nearly 40 years, mechanism and critical players of mammalian TCR remain unclear. STK19 a factor affecting cell survival recovery RNA synthesis in response DNA damage, however, whether it necessary component unknown. Here, we demonstrated that essential human TCR. Mechanistically, recruited damage sites through direct interaction with CSA. It can also interact...
Transcription-blocking lesions (TBLs) stall elongating RNA polymerase II (Pol II), which then initiates transcription-coupled repair (TCR) to remove TBLs and allow transcription recovery. In the absence of TCR, eviction lesion-stalled Pol is required for alternative pathways address damage, but mechanism unclear. Using Protein-Associated DNA Damage Sequencing (PADD-seq), this study reveals that p97-proteasome pathway can evict independently repair. Both TCR repair-independent require CSA...
The hypercoagulable state is a hallmark for patients with multiple myeloma (MM) and associated disease progression. Activated platelets secrete exosomes promote solid tumor growth. However, the role of platelet-derived in MM not fully clear. We aim to study underlying mechanism how cell Flow cytometry, Western blot, proteome analysis, co-immunoprecipitation, immunofluorescence staining, NOD/SCID mouse subcutaneous transplantation model were performed investigate exosomal LRG1 on Peripheral...