A5012041865- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Parathyroid Disorders and Treatments
- Pulmonary Hypertension Research and Treatments
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Lipoproteins and Cardiovascular Health
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Infective Endocarditis Diagnosis and Management
- Cell Adhesion Molecules Research
- Dialysis and Renal Disease Management
- Frailty in Older Adults
- Blood Pressure and Hypertension Studies
- Coronary Interventions and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- Gout, Hyperuricemia, Uric Acid
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2025
National Clinical Research
2018-2024
Peking Union Medical College Hospital
2014-2019
Fu Wai Hospital
2011-2019
First Hospital of China Medical University
2016
China Medical University
2016
Objective. This study was performed to explore the clinical manifestations and longterm prognosis in patients with Takayasu arteritis (TA) pulmonary artery involvement (PAI). Methods. The medical records of 194 TA who underwent traditional catheter angiography or computed tomography from 2009 2016 were retrospectively reviewed. manifestations, angiographic features, mortality 128 PAI further analyzed. Results. Patients had a higher risk hypertension (PH) than alone (61.7% vs 7.6%, p <...
Background: Statin therapy is associated with an increased risk of new-onset diabetes (NOD), possibly due to a reduction in coenzyme Q10 (CoQ10) levels as result statin use. This study aimed investigate the relationship between exogenous CoQ10 supplementation and development NOD. Methods: included 4394 participants from National Health Nutrition Examination Survey (NHANES). Baseline characteristics were compared those without NOD CoQ10. Univariate logistic regression was performed identify...
Arterial stiffness is recognized as a new risk factor for stroke. However, the association between estimated pulse wave velocity (ePWV), well-established indirect measure of arterial and stroke among older adults, remains incompletely investigated. This study utilized data from 3 prospective, nationally representative cohorts: Health Retirement Study in United States, English Longitudinal Aging Kingdom, China China. ePWV was calculated based on age mean pressure. Cox proportional hazard...
Research results on the association between alcohol consumption and abdominal aortic calcification (AAC) has yielded inconsistent results. There is a paucity of evidence smoking with AAC in general middle-aged elderly population, including age subgroups. This study utilizes nationwide survey data to explore these associations. Data from National Health Nutrition Examination Survey (NHANES) 2013-2014 participants receiving dual X-ray absorptiometry were analyzed. severity was assessed using...
To investigate the probable pathogenesis, clinical features, diagnosis, and therapy of patients with pulmonary hypertension (PH) in Takayasu arteritis (TA).A total 48 TA who had PH, 20 arterial involvement (PA) without 30 idiopathic (IPAH) were enrolled study from 2009 to 2013.Among 36 (75.0%) PA, left heart disease (LHD) was present 12 (25.0%). Serum levels big endothelin 1 (ET-1) independently correlated systolic pressure (r = 0.33, p 0.04). Compared IPAH, PH because PA underwent right...
Serum lycopene exhibits distinct associations with all-cause and cardiovascular mortality in populations or without obesity.
The role of the lipoprotein-associated phospholipase A(2) gene (PLA2G7) in atherosclerosis remains controversial. We investigated frequency single-nucleotide polymorphisms (SNPs) PLA2G7 (rs16874954 and rs1051931) their association with coronary artery disease (CAD) a cohort CAD patients (n= 806) age-matched healthy controls 482) Chinese Han population. VF FF genotype rs16874954 was significantly more frequent (13.5%) than (9.3%, P= 0.024). remained after adjustment for age, gender, body mass...
Obesity, birth weight and lifestyle factors have been found associated with the risk of frailty in observational studies, but whether these associations are causal is uncertain. We conducted a two-sample Mendelian randomization study to investigate associations. Genetic instruments exposures at genome-wide significance level (p < 5 × 10−8) were selected from corresponding association studies (n = 143,677 703,901 individuals). Summary-level data for index obtained UK Biobank 164,610) Swedish...
Objective. Tumor necrosis factor-α (TNF-α) is a multifunctional proinflammatory cytokine that influences the pathogenesis of Takayasu arteritis (TA). There still no evidence relationship between TNF-α gene promoter polymorphisms and TA. We examined whether variations in region may lead to TA susceptibility disease progression. Methods. Five (−238G/A, −308G/A, −857C/T, −863C/A, −1031C/T) were analyzed 110 Chinese Han patients with TA, control group 362 unrelated healthy individuals. Genotypes...
The integral changes of coagulation and fibrinolysis, their relationships with inflammation in patients Takayasu arteritis (TA) remain undetermined. purpose this study was to analyze the fibrinolysis process TA by thrombelastography (TEG).A total 127 55 healthy controls were enrolled. Patients grouped according disease activity. routine hematological parameters, traditional assays, TEG parameters summarized retrospectively.A shorter K time, larger alpha angle, higher levels MA, MA(A), G, TPI...
To determine the prognosis of Takayasu arteritis (TA) patients with moderate-to-severe aortic regurgitation treated surgical vs conservative treatment and to identify independent prognostic factors long-term outcomes.Between January 2002 2017, 101 consecutive TA either (n = 38) or 63) treatments were investigated in this retrospective observational case-control study. The primary end point was all-cause mortality, secondary comprised combined points death, non-fatal stroke cardiac events...
Objective. Increased levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with cardiovascular morbidity and mortality. Inflammation may also affect NT-proBNP. We investigated the relationship NT-proBNP inflammation, disease activity, severity, progression Takayasu arteritis (TA). Methods. Plasma were determined in 68 patients TA 90 control subjects. Disease activity severity defined according to National Institutes Health Ishikawa’s criteria, respectively. Results....