A5048644162- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- RNA modifications and cancer
- Viral-associated cancers and disorders
- PI3K/AKT/mTOR signaling in cancer
- Sphingolipid Metabolism and Signaling
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Cytomegalovirus and herpesvirus research
- RNA Research and Splicing
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Toxin Mechanisms and Immunotoxins
- Fluoride Effects and Removal
- Pediatric health and respiratory diseases
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Medical Research and Treatments
- Epigenetics and DNA Methylation
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Signaling Pathways in Disease
Beijing Wantai Biological Pharmacy (China)
2025
Wuhan University
2022-2024
State Key Laboratory of Chemobiosensing and Chemometrics
2024
Hunan University
2023-2024
Shanxi Medical University
2020-2023
Peking University First Hospital
2023
Peking University
2014-2023
Tangshan People's Hospital
2022
Stomatology Hospital
2014
Kaposi’s sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus with the capacity to establish life-long latent infection. During infection, viral genome persists as circular episome that associates cellular histones and exists nonintegrated minichromosome in nucleus of infected cells. Chromatin structure epigenetic programming are required for proper control gene expression stable maintenance DNA. However, there still limited knowledge regarding how host regulates chromatin...
Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma family, which can cause human malignancies including Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman's diseases. KSHV typically maintains a persistent latent infection within host. However, after exposure intracellular or extracellular stimuli, lytic replication be reactivated. The reactivation process of triggers innate immune response limit viral replication. Here, we found that transcriptional...
Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus that encodes numerous cellular homologs, including cyclin D, G protein-coupled protein, interleukin-6, and macrophage inflammatory proteins 1 2. KSHV vCyclin encoded by ORF72, the homolog of cyclinD2. can regulate replication cell proliferation constitutively activating cyclin-dependent kinase 6 (CDK6). However, regulatory mechanism has not been fully elucidated. In present study, we identified host protein named...
The generation of deoxyinosine (dI) in DNA is one the most important sources genetic mutations, which may lead to cancer and other human diseases. A further understanding biological consequences dI necessitates identification functional characterizations dI-binding proteins. Herein, we employed a mass spectrometry-based proteomics approach detect cellular proteins that sense presence DNA. Our results demonstrated mitochondrial heat shock protein 60 (HSPD1) can interact with dI-bearing We...
Amiodarone (AM) is one of the most effective antiarrhythmic drugs and normally administrated by intravenous infusion which liable to cause serious phlebitis. The therapeutic for preventing this complication are limited. Intermedin (IMD), a member calcitonin family, has broad spectrum biological effects including anti-inflammatory effects, antioxidant activities, antiapoptosis. But now, protective IMD against amiodarone-induced phlebitis underlying molecular mechanism not well understood. In...
Glomerular mesangial cell (MC) proliferation is one of the causative factors glomerular diseases and their prominent pathological features. Rapamycin can inhibit MC slow progression to chronic renal fibrosis. The present study was designed observe role rapamycin in explore mechanism by which acts on Akt MAPK/ERK1/2 pathways cells. MTT assay flow cytometry were used evaluate cycle phase cells respectively. mRNA expression level p70S6K detected RT-qPCR. Western blotting performed determine...
To establish the Omaha System-based intensive care of children with viral encephalitis, compared conventional nursing applied in severe encephalitis for clinical symptoms, motor function, incidence complications, and influence quality life, to way provide certain scientific basis.62 cases diagnosed treated our hospital from X month 20XX were randomly divided into 31 intervention group control group. The received routine nursing, added system on basis recovery time symptoms signs, FMA score,...
To investigate the role of MetaLnc9 in osteogenesis human bone marrow mesenchymal stem cells (hBMSCs).We used lentiviruses to knockdown or overexpress hBMSCs. qRT-PCR was employed determine mRNA levels osteogenic-related genes transfected cells. ALP staining and activity assay, ARS quantification were identify degree osteogenic differentiation. Ectopic formation conducted examine vivo. AKT pathway activator SC-79 inhibitor LY294002 validate relationship between signaling pathway.The...
Abstract Background Esophageal cancer (EC) is the sixth deadliest in world. There has been no breakthrough research on EC past few decades. Epidermal growth factor-like protein 6 (EGFL6), as a member of epidermal factor superfamily, plays an important role occurrence and development some tumors. However, EGFL6 never explored. Methods Immunohistochemical staining was used to evaluate expression level EGEC6 human its adjacent non-tumor tissues, analyzed correlation between clinical...
Introduction: Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE) as well the leading cause mortality in patients. Previous studies have revealed that S1P level elevated plasma samples SLE and LN Also, murine models, was found serum kidney tissue. Targeting receptors, especially S1PR1, exhibited therapeutic effects improving symptoms mouse models. However, few discussed potential relevance S1P/S1PR to pathogenesis LN. Macrophages can polarize into two...