A5044403642- Epigenetics and DNA Methylation
- COVID-19 epidemiological studies
- Genetic Associations and Epidemiology
- Nutrition and Health in Aging
- COVID-19 Clinical Research Studies
- Cancer-related gene regulation
- Frailty in Older Adults
- Cancer-related Molecular Pathways
- Air Quality and Health Impacts
- Dementia and Cognitive Impairment Research
- Body Composition Measurement Techniques
- Intergenerational Family Dynamics and Caregiving
- Health, Environment, Cognitive Aging
- Hippo pathway signaling and YAP/TAZ
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Acute Ischemic Stroke Management
- Noise Effects and Management
- Climate Change and Health Impacts
- Lower Extremity Biomechanics and Pathologies
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer, Lipids, and Metabolism
- Neurosurgical Procedures and Complications
- MicroRNA in disease regulation
- Kruppel-like factors research
Universitat Pompeu Fabra
2019-2024
Hospital del Mar Research Institute
2019-2024
Biomedical Research Institute of Lleida
2024
Hospital Del Mar
2020-2024
Biogipuzkoa Health Research Institute
2023-2024
CIC bioGUNE
2024
Donostia Unibertsitate Ospitalea
2023
Agència de Qualitat i Avaluació Sanitàries de Catalunya
2021-2022
Biomedical Research Institute
2022
Universitat Autònoma de Barcelona
2019-2021
Abstract Background The role of children in household transmission severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. We describe the epidemiological and clinical characteristics with disease 2019 (COVID-19) Catalonia, Spain, investigate dynamics. Methods A prospective, observational, multicenter study was performed during summer school periods (1 July 2020–31 October 2020) to analyze features viral dynamics COVID-19 patients aged <16 years. pediatric index...
Evidence for the association between environmental exposures and ischemic stroke (IS) is limited inconsistent. We aimed to assess relationship exposure air pollutants, residential surrounding greenness, incident IS, identify population subgroups particularly sensitive these exposures. used data from administrative health registries of public healthcare system in Catalonia, Spain construct a cohort individuals aged 18 years older without previous diagnosis at 1st January 2016 (n = 3 521 274)....
The association between long-term exposure to ambient air pollutants and severe COVID-19 is uncertain. We followed 4,660,502 adults from the general population in 2020 Catalonia, Spain. Cox proportional models were fit evaluate annual averages of PM2.5, NO2, BC, O3 at each participant's residential address COVID-19. Higher BC was associated with an increased risk hospitalization, ICU admission, death, hospital length stay. An increase 3.2 µg/m3 PM2.5 a 19% (95% CI, 16-21) hospitalizations....
Abstract Background and aims Stroke is the leading cause of adult-onset disability. Although clinical factors influence stroke outcome, there a significant variability among individuals that may be attributed to genetics epigenetics, including DNA methylation (DNAm). We aimed study association between DNAm prognosis. Methods results To aim, we conducted two-phase (discovery-replication meta-analysis) in Caucasian patients with ischemic from two independent centers (BasicMar [discovery, N =...
DNA methylation is dynamic, varies throughout the life course, and its levels are influenced by lifestyle environmental factors, as well genetic variation. The leading variants at stroke risk loci identified to date explain roughly 1–2% of heritability. Most these single nucleotide polymorphisms situated within a regulatory sequence marked DNase I hypersensitivity sites, which would indicate involvement an epigenetic mechanism. To detect associated with occurrence subtypes.A two-stage...
Stroke onset in women occurs later life compared with men. The underlying mechanisms of these differences have not been established. Epigenetic clocks, based on DNA methylation (DNAm) profiles, are the most accurate biological age estimate. acceleration (EAA) measures indicate whether an individual is biologically younger or older than expected. Our aim was to analyze sexual dichotomy at stroke conditioned by EAA.We used 2 DNAm datasets from whole blood samples case-control genetic studies...
Abstract Through GWAS studies we identified PATJ associated with functional outcome after ischemic stroke (IS). The aim of this study was to determine role in brain endothelial cells (ECs) the context outcome. expression analyses patient’s blood revealed that: (i) risk allele rs76221407 induces higher , (ii) is downregulated 24 h IS, and (iii) its significantly lower those patients independence, measured at 3 months modified Rankin scale ((mRS) ≤2), compared marked disability (mRS = 4–5). In...
We analyzed contagions of coronavirus disease 2019 inside school bubble groups in Catalonia, Spain, the presence strong nonpharmaceutical interventions from September to December 2020. More than 1 million students were organized and monitored by Health Educational departments.We had access 2 data sources, both employed for analysis, one is Catalan surveillance system other educational department. As soon as a positive index case detected health system, isolation required all members group,...
Objective: We describe and analyze the childhood (<18 years) COVID-19 incidence in Catalonia, Spain, during first 36 weeks of 2020-2021 school-year to compare it with adults. Methods: Data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests were obtained from Catalan Agency for Quality Health Assessment. Overall, 7,203,663 SARS-CoV-2 performed, which 491,819 positive (6.8%). collected epidemiological data including age-group incidence, diagnostic effort, positivity...
Post-ischemic stroke (IS) outcomes vary widely among individuals, independently of clinical factors. This variability could be related to epigenetic mechanisms that regulate biological processes involved in recovery after ischemia. While several microRNAs (miRNAs) and their target genes are implicated the pathophysiology IS, role functional remains unclear. Our aim is identify potential miRNAs associated with 3-month outcome patients IS.
The aim of the study was to determine association between previous stroke and mortality after coronavirus disease 2019 (COVID-19) according sex, age groups, subtypes.Prospective population-based cohort including all COVID-19 positive cases February 1 July 31, 2020. Comorbidities were extracted using linked health administration databases. Previous included transient ischemic attack, stroke, hemorrhagic spontaneous subarachnoid hemorrhage, combined for with more than one category. Other...
Frailty resulting from the loss of muscle quality can potentially be delayed through early detection and physical exercise interventions. There is a demand for cost-effective tools objective evaluation quality, in both cross-sectional longitudinal assessments. Literature suggests that quantitative analysis ultrasound data captures morphometric, compositional, microstructural properties, while biological assays derived blood samples are associated with functional information.
In this manuscript we studied the relationship between WMH and biological age (B-age) in patients with acute stroke. We included study 247 stroke recruited at Hospital del Mar having both epigenetic (DNA methylation) magnetic resonance imaging data. were measured using a semi-automated method. B-age was calculated two widely used methods: Hannum Horvath formulas. multiple linear regression models to interrogate role of on volume after adjusting for chronological (C-age) other covariables....
Age acceleration (Age-A) is a useful tool that able to predict broad range of health outcomes. It necessary determine DNA methylation levels estimate it, and it known Age-A influenced by environmental, lifestyle, vascular risk factors (VRF). The aim this study the contribution these easily measurable in patients with cerebrovascular disease (CVD), using different machine learning (ML) approximations, try find more accessible model Age-A. We studied CVD cohort 952 information about VRF,...
Abstract Here we analyse the epidemiological trend of incidence COVID-19 in children Catalonia (Spain) during first 20 weeks 2020-2021 school year. This study demonstrates that while schools were open rate among remained significantly lower than general population, despite a greater diagnostic effort children. These results suggest have not played significant role SARS-CoV-2 dissemination Catalonia.
We analyzed the characteristics of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infected children during lock-down period in Catalonia (Spain), and their transmission role within households. Among 295 traced household contacts 89 pediatric patients, were classified as final index cases only 3.4% homes.
BACKGROUND: A stroke?s functional outcome presents vast variability among patients, which is influenced by age, sex, characteristics of the lesion, and genetic factors. However, there very little knowledge about stroke recovery genetics. Recently, some GWAS (Genome-Wide Association Studies) have highlighted involvement common or low-frequency variants near within PATJ, PPP1R21, PTCH1, NTN4 TEK genes, whereas role rare still unclear. This study aims to identify contributions differences in...
Abstract Metastatic hormone-naïve prostate cancer (mHNPC) is an infrequent form of this tumour type that characterized by metastasis at the time diagnosis and accounts for 50% cancer-related deaths. Despite extensive characterization localized metastatic castration resistant (mCRPC), molecular characteristics mHNPC remain largely unexplored. Here we provide first transcriptomics mHNPC. We generated discovery validation bulk single-cell RNA-Seq datasets performed integrative computational...
<b><i>Background and Purpose:</i></b> The minor stroke concept has not been analyzed in intracerebral hemorrhage (ICH) patients. Our purpose was to determine the optimal cut point on NIH Stroke Scale (NIHSS) for defining a ICH (mICH) patients with primary ICH. <b><i>Methods:</i></b> An considered if associated favorable 3-month outcome (modified Rankin score ≤2). For supratentorial ICH, discovery cohort consisted of 478 prospectively admitted...
Background and purpose The role of copy number variation (CNV) in stroke susceptibility outcome has yet to be explored. Copy Number Variation Stroke (CaNVAS) Risk Outcome study addresses this knowledge gap. Methods Over 24,500 well-phenotyped IS cases, including subtypes, over 43,500 controls have been identified, all with readily available genotyping on GWAS exome arrays, case measures outcome. To evaluate CNV-associated risk it is planned to: 1) perform Discovery using several analytic...
ABSTRACT Rationale DNA methylation is dynamic, varies throughout the life course, and its levels are influenced by lifestyle environmental factors, as well genetic variation. The leading variants at stroke risk loci identified to date explain roughly 1–2% of heritability. Most these single nucleotide polymorphisms situated within a regulatory sequence marked DNase I hypersensitivity sites, which would indicate involvement an epigenetic mechanism. Objective To detect associated occurrence...
Background: Evidence for the association between environmental exposures and ischemic stroke (IS) is limited inconsistent. We aimed to assess relationship long-term exposure air pollutants, residential surrounding greenness, incident IS, identify population subgroups particularly vulnerable these exposures.Methods: used data from administrative health registries of public healthcare system in Catalonia, Spain construct a cohort individuals aged 18 years older without previous diagnosis at 1...
Abstract Background Frailty derived from muscle quality loss can potentially be delayed through early detection and physical exercise interventions. There is a need for affordable tools the objective evaluation of quality, in both cross-sectional longitudinal assessment. Literature suggests that quantitative analysis ultrasound data captures morphometric, compositional microstructural properties, while biological essays blood samples are associated with functional information. The aim this...
<title>Abstract</title> Through GWAS studies we identified<italic>PATJ</italic>associated with functional outcome after ischemic stroke (IS). The aim of this study was to determine PATJ role in brain endothelial cells (ECs) the context outcome.<italic>PATJ</italic>expression analyses patient’s blood revealed that: (i) risk allele rs76221407 induces higher expression of<italic>PATJ</italic>, (ii)<italic>PATJ</italic>is downregulated 24 hours IS and (iii) its is significantly lower those...