A5033385760- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrovascular and Carotid Artery Diseases
- Neurosurgical Procedures and Complications
- Cardiovascular Health and Disease Prevention
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Peripheral Artery Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Substance Abuse Treatment and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Stroke Rehabilitation and Recovery
- Evolutionary Psychology and Human Behavior
- Statistical Methods and Bayesian Inference
- Attachment and Relationship Dynamics
- Optical Imaging and Spectroscopy Techniques
- Infrared Thermography in Medicine
- Personality Disorders and Psychopathology
- Neural dynamics and brain function
- Sexual function and dysfunction studies
- Body Image and Dysmorphia Studies
- Adolescent Sexual and Reproductive Health
- Vascular Malformations Diagnosis and Treatment
Hospital de Sant Pau
2014-2024
Institut de Recerca Sant Pau
2024
University of Washington
2014-2023
Clinical Trial Investigators
2022
Universitat Autònoma de Barcelona
2011-2020
Biomedical Research Institute
2016-2019
Hospital Del Mar
2016
Hospital Universitari Germans Trias i Pujol
2014-2016
Hospital Clínic de Barcelona
2016
Hospital Universitari Arnau de Vilanova
2014-2016
<h3>Importance</h3> It is estimated that only 27% of patients with acute ischemic stroke and large vessel occlusion who undergo successful reperfusion after mechanical thrombectomy are disability free at 90 days. An incomplete microcirculatory might contribute to these suboptimal clinical benefits. <h3>Objective</h3> To investigate whether treatment adjunct intra-arterial alteplase improves outcomes following reperfusion. <h3>Design, Setting, Participants</h3> Phase 2b randomized,...
It is uncertain whether neurogenesis occurs in humans after stroke. We studied the morphologic changes that occurred subventricular zone (SVZ) patients who died following an acute ischemic stroke.We examined coronal brain slices from a first-ever cerebral nonlacunar infarction middle artery territory. evaluated ipsilateral and contralateral SVZ by light electron microscopy. Using immunochemistry with Ki-67 PCNA, we detected cell proliferation. used Tuj-1 for immature neurons PSA-NCAM...
Whether intravenous thrombolysis adds a further benefit when given before endovascular thrombectomy (EVT) is unknown. Furthermore, delays time to groin puncture, mainly among drip and ship patients.Using region-wide registry data, we selected cases that received direct EVT or combined thrombolysis+EVT for anterior circulation strokes between January 2011 October 2015. Treatment effect was estimated by stratification on propensity score. The average odds ratios the association of treatment...
The dissemination and evaluation of evidence-based behavioral treatments for substance abuse problems rely on the counselor interventions. In Motivational Interviewing (MI), a treatment that directs therapist to utilize particular linguistic style, proficiency is assessed via coding-a time consuming, nontechnological approach. Natural language processing techniques have potential scale up such as MI. We present novel computational approach assessing components MI, focusing 1 specific...
There are no generally accepted criteria for the etiologic classification of intracerebral hemorrhage (ICH). For this reason, we have developed a set and applied them to large number patients determine their utility.The H-ATOMIC includes 7 categories: Hypertension, cerebral Amyloid angiopathy, Tumour, Oral anticoagulants, vascular Malformation, Infrequent causes Cryptogenic. each category, etiology is scored with three degrees certainty: Possible(3), Probable(2) Definite(1). Our aim was...
We tested the hypothesis that risk of intracranial hemorrhage (ICH) in patients with cardioembolic ischemic stroke who are treated oral anticoagulants (OAs) can be predicted by evaluating surrogate markers hemorrhagic-prone cerebral angiopathies using a baseline MRI.Patients were participants multicenter and prospective observational study. They older than 64 years, had recent stroke, new users OAs. underwent MRI analysis to evaluate microbleeds, white matter hyperintensities, cortical...
Background and purpose Plaque neovascularization is a hallmark of carotid plaque vulnerability. With contrast‐enhanced ultrasound (CEUS) it possible to visualize neovessels in vivo . Our aim was determine if CEUS‐detected were associated with stroke recurrences patients recent atherosclerosis. Methods We conducted prospective study consecutive at least one atherosclerotic the internal artery on side consistent symptoms. All our underwent examination including CEUS study. Neovascularization...
Whether the outcome of patients with spontaneous intracerebral hemorrhage (ICH) differs depending on type hospital where they are admitted is uncertain. The objective this study was to determine influence at admission (telestroke center [TSC], primary stroke [PSC], or comprehensive [CSC]) for ICH. We hypothesized that outcomes may be better a CSC.
Prevalence rates for infidelity in American marriages range from 20% to 40%. Nevertheless, there is a paucity of research on the effectiveness couple therapy when has been an infidelity. In present study posttherapy outcomes 19 couples were examined up 5 years following participation larger (N 134) randomized clinical trial therapy. All Integrative Behavioral Couple Therapy (IBCT) or Traditional (TBCT) regardless status. They assessed approximately every 6 months posttherapy, and current...
Infidelity is an often cited problem for couples seeking therapy, but the research literature to date very limited on couple therapy outcomes when infidelity a problem. The current study secondary analysis of community-based sample in Germany and Austria. Outcomes 145 who reported as their relationship were compared with 385 sought other reasons. Analyses based hierarchical linear modeling revealed that significantly more distressed depressive symptoms at start continued improving through...
Abstract Objectives The levels of circulating endothelial progenitor cells ( EPC s) in ischemic stroke have not been studied extensively and reported results are inconsistent. We aimed to investigate the time course, prognostic relevance, variables associated with counts patients at different points. Material methods prospectively 146 consecutive within first 48 h from onset symptoms (baseline). evaluated demographic data, classical vascular risk factors, treatment thrombolysis statins,...
Stroke onset in women occurs later life compared with men. The underlying mechanisms of these differences have not been established. Epigenetic clocks, based on DNA methylation (DNAm) profiles, are the most accurate biological age estimate. acceleration (EAA) measures indicate whether an individual is biologically younger or older than expected. Our aim was to analyze sexual dichotomy at stroke conditioned by EAA.We used 2 DNAm datasets from whole blood samples case-control genetic studies...
Owing to the high risk of recurrence, identifying indicators carotid plaque vulnerability in atherothrombotic ischemic stroke is essential. In this study, we aimed identify modified LDLs and antioxidant enzymes associated with plasma from patients a recent atherosclerosis. Patients underwent an ultrasound, CT-angiography, 18F-FDG PET. A blood sample was obtained (n = 64, 57.8% stenosis ≥50%) healthy controls 24). Compared controls, showed lower levels total cholesterol, LDL HDL...
Remote parenchymal hemorrhage (rPH) after intravenous thrombolysis with recombinant tissue-type plasminogen activator may be associated cerebral amyloid angiopathy, although supportive data are limited. We aimed to investigate risk factors of rPH activator.This is an observational study patients ischemic stroke who were treated and included in a multicenter prospective registry. was defined as any extraischemic detected the follow-up computed tomography. collected demographic, clinical,...
Background and Purpose We evaluated the hypothesis that number of circulating EPC could be associated with risk stroke recurrence (SR) or vascular events (VE) after an ischemic stroke. Methods studied prospectively consecutive patients cerebral infarction within first 48 hours onset. recorded demographic factors, previous Rankin scale (RS) score, etiology. analyzed counts by flow cytometry in blood collected at day 7 defined as CD34+/CD133+/KDR+ cells. Mean follow-up was 29.3 ± 16 months. SR...
In this pilot study, we have evaluated bedside diffuse optical monitoring combining correlation spectroscopy and near-infrared to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in acute ischemic stroke.Frontal lobes five patients middle artery occlusion were measured bilaterally during rtPA treatment.Both ipsilesional contralesional hemispheres showed significant increases blood flow, total hemoglobin...
Abstract 18 F-fluorodeoxyglucose positron emission tomography ( F-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence in patients with atherothrombotic stroke. The aim of the study was to identify plasma inflammatory biomarkers associated according uptake. We conducted a prospective consecutive adult recent (< 7 days) anterior circulation ischemic at least one atherosclerotic ipsilateral internal artery. included 64 patients, 57.8% whom showed stenosis ≥ 50%....
We tested the hypothesis that proteins of hemostasia could be associated with hematoma growth (HG) in patients acute intracerebral hemorrhage.We prospectively studied spontaneous supratentorial hemorrhage within first 6 hours after onset symptoms. HG was defined as an increase > 33% volume on CT obtained 24 to 72 symptoms comparison at admission. collected admission and follow-up blood samples. measured fibrinogen, factor XIII, thrombin activatable fibrinolysis inhibitor, plasminogen...
We performed an observational study that compared baseline and subsequent blood pressure (BP) measurements its association with haematoma enlargement (HE) in patients intracerebral haemorrhage (ICH).We prospectively studied consecutive supratentorial spontaneous ICH within the first 6 h after onset of symptoms. HE was defined as increase >or=33% volume on CT obtained 24-48 symptoms at admission. recorded systolic BP (SBP), diastolic (DBP) mean (MBP) admission 6, 12, 18 24 onset; maximum SBP,...
Abstract We investigated whether pre-treatment with statins is associated surrogate markers of amyloid and hypertensive angiopathies in patients who need to start long-term oral anticoagulation therapy. A prospective multicenter study naive for anticoagulants, had an acute cardioembolic stroke. MRI was performed at admission evaluate microbleeds, leukoaraiosis superficial siderosis. collected data on the specific statin compound, dose intensity. bivariate analyses a logistic regression...
Background and purpose Remote parenchymal haemorrhage (rPH) after intravenous thrombolysis is defined as hemorrhages that appear in brain regions without visible ischemic damage, remote from the area of ischemia causing initial stroke symptom. The pathophysiology rPH not clear may be explained by different underlying mechanisms. We hypothesized have risk factors according to bleeding location. report variables we found associated with deep lobar thrombolysis. Methods This a descriptive study...
Background and Purpose: Mechanical thrombectomy (MT) is effective for acute ischemic stroke (AIS) in selected patients with large intracranial vessel occlusion. A minority of AIS receive MT. We aimed to describe the reasons excluding Methods: evaluated a prospective population-based multicenter registry (Codi Ictus Catalunya registry) that includes all code activations from January June 2018 Catalonia, Spain. analyzed major not treating Results: Stroke was activated 3060 patients. Excluding...