A5051708450- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Hepatitis B Virus Studies
- Blood donation and transfusion practices
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Vibrio bacteria research studies
- Infectious Encephalopathies and Encephalitis
- Liver Disease Diagnosis and Treatment
- Free Radicals and Antioxidants
- Cholinesterase and Neurodegenerative Diseases
- Hepatitis C virus research
- Blood groups and transfusion
Harvard University
2023-2025
Boston VA Research Institute
2023-2024
Shenzhen Blood Center
2014
Abstract Eastern equine encephalitis virus (EEEV) is the most virulent alphavirus that infects humans, and many survivors develop neurological sequelae, including paralysis intellectual disability. Alphavirus spike proteins comprise trimers of heterodimers glycoproteins E2 E1 mediate binding to cellular receptors fusion host cell membranes during entry. We recently identified very-low density lipoprotein receptor (VLDLR) apolipoprotein E 2 (ApoER2) as for EEEV a distantly related alphavirus,...
Western equine encephalitis virus (WEEV) is an arthropod-borne (arbovirus) that frequently caused major outbreaks of in humans and horses the early twentieth century, but frequency has since decreased markedly, strains this alphavirus isolated past two decades are less virulent mammals than 1930s 1940s
Abstract After decades of inactivity throughout the Americas, western equine encephalitis virus (WEEV) recently re-emerged in South America, causing a large-scale outbreak humans and horses. WEEV binds protocadherin 10 (PCDH10) as receptor; however, nonpathogenic strains no longer bind human or PCDH10 but retain ability to avian receptors. Highly virulent can also very low-density lipoprotein receptor (VLDLR) apolipoprotein E 2 (ApoER2) alternative Here, by determining cryo-electron...
Western equine encephalitis virus (WEEV) is an arbovirus that historically caused large outbreaks of throughout the Americas. WEEV binds protocadherin 10 (PCDH10) as a receptor, and highly virulent ancestral strains also bind low-density lipoprotein receptor (LDLR)-related proteins. As declined human pathogen in North America over past century, isolates have lost ability to mammalian receptors while still recognizing avian receptors. To explain shifts dependencies assess risk re-emergence,...
BACKGROUND Gastric cancer is the fifth most common malignancy worldwide. In early stages, no obvious symptoms are usually observed in gastric patients, and it especially hard to distinguish from benign diseases, resulting delayed diagnosis poor prognosis. Common biomarkers of cancer, such as CEA CA19-9, also elevated diseases. There an urgent need develop a convenient reliable biomarker for differentiating between METHODS This study retrospectively analyzed data 126 including 73 patients 53...
Objective To explore suitable strategy for blood donation safety under human immunodeficiency virus (HIV) infection new situation.Methods From January 2008 to December 2012,a total of 438 123 voluntary unpaid donors in Shenzhen Blood Station were included this study.According the definition classification Whole and component donor selection requirements (GB 18467-2011),all classified into 3 groups:regular group (n =87 460),unfixed =67 812),and primary (n=282 851).Their samples screened by...
Alphaviruses are arthropod-borne enveloped RNA viruses that include several important human pathogens with outbreak potential. Among them, eastern equine encephalitis virus (EEEV) is the most virulent, and many survivors develop neurological sequelae, including paralysis intellectual disability. The spike proteins of alphaviruses comprise trimers heterodimers their envelope glycoproteins E2 E1 mediate binding to cellular receptors fusion host cell membranes during entry. We recently...