A5035060014- Mosquito-borne diseases and control
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Nonmelanoma Skin Cancer Studies
- Antimicrobial Resistance in Staphylococcus
- Infectious Encephalopathies and Encephalitis
- CAR-T cell therapy research
- CRISPR and Genetic Engineering
- Cutaneous Melanoma Detection and Management
- Nanowire Synthesis and Applications
- Skin Protection and Aging
- RNA regulation and disease
- Virus-based gene therapy research
- Vibrio bacteria research studies
- Infective Endocarditis Diagnosis and Management
- HIV Research and Treatment
- Viral Infections and Vectors
- Orthopedic Infections and Treatments
- RNA Research and Splicing
Boston VA Research Institute
2021-2024
Harvard University
2016-2024
Brigham and Women's Hospital
2019
Massachusetts General Hospital
2016
Western equine encephalitis virus (WEEV) is an arthropod-borne (arbovirus) that frequently caused major outbreaks of in humans and horses the early twentieth century, but frequency has since decreased markedly, strains this alphavirus isolated past two decades are less virulent mammals than 1930s 1940s
While 18 putative RNA helicases are involved in ribosome biogenesis Saccharomyces cerevisiae , their enzymatic properties have remained largely biochemically uncharacterized. To better understand function, we examined the of Dpb8, a DExD/H box protein previously shown to be required for synthesis 18S rRNA. As expected an helicase, demonstrate that recombinant Dbp8 has ATPase activity vitro and this is dependent on intact domain. Strikingly, identify Esf2, nucleolar binding protein, as...
Abstract Objectives 16S ribosomal RNA (rRNA) sequencing is a powerful but expensive tool for the identification of bacteria in culture-negative endocarditis. Histologic criteria to screen formalin-fixed, paraffin-embedded (FFPE) specimens testing are evaluated. Methods Sixty-eight cases infective endocarditis and controls were histologically reviewed analyzed by rRNA gene sequencing. Results Sequencing identified specific pathogenic organism 33 (49%) 68 with acute inflammation 0 10 (P =...