A5047654289- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Cutaneous Melanoma Detection and Management
- Cancer and Skin Lesions
- Phytochemicals and Antioxidant Activities
- Mosquito-borne diseases and control
- Malaria Research and Control
- Nonmelanoma Skin Cancer Studies
- Epigenetics and DNA Methylation
- Parathyroid Disorders and Treatments
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- Mast cells and histamine
- Garlic and Onion Studies
- CRISPR and Genetic Engineering
- Vasculitis and related conditions
- Cancer-related gene regulation
- RNA modifications and cancer
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Bone Tissue Engineering Materials
- Alkaline Phosphatase Research Studies
- Respiratory viral infections research
Guangzhou University of Chinese Medicine
2025
Guangdong Pharmaceutical University
2024-2025
Shenzhen Bay Laboratory
2022-2025
Hunan Agricultural University
2023-2024
Guilin Medical University
2016-2024
Janssen (United States)
2021-2024
Yuhuangding Hospital
2023-2024
The University of Texas Medical Branch at Galveston
2020-2023
Peking University
2009-2023
Peking University Third Hospital
2013-2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on basis their potential for altered transmissibility, pathogenicity, and coverage by vaccines therapeutic agents1-5. Here we show serum samples taken from twenty human volunteers, two or four weeks after second dose BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020)...
SARS-CoV-2 Delta variant has rapidly replaced the Alpha around world. The mechanism that drives this global replacement not been defined. Here we report spike mutation P681R plays a key role in Alpha-to-Delta replacement. In replication competition assay, efficiently outcompeted human lung epithelial cells and primary airway tissues. bearing Alpha-spike glycoprotein replicated less than wild-type variant, suggesting importance of enhancing viral replication. accumulated located at furin...
Summary Beginning in the summer of 2020, a variant SARS-CoV-2, cause COVID-19 pandemic, emerged United Kingdom (UK). This B.1.1.7 increased rapidly prevalence among sequenced strains, attributed to an increase infection and/or transmission efficiency. The UK has 19 nonsynonymous mutations across its viral genome including 8 substitutions or deletions spike protein, which interacts with cellular receptors mediate and tropism. Here, using reverse genetics approach, we show that, individual...
A spike protein mutation D614G became dominant in SARS-CoV-2 during the COVID-19 pandemic. However, mutational impact on viral spread and vaccine efficacy remains to be defined. Here we engineer USA-WA1/2020 strain characterize its effect replication, pathogenesis, antibody neutralization. The significantly enhances replication human lung epithelial cells primary airway tissues, through an improved infectivity of virions with receptor-binding domain "up" conformation for binding ACE2...
Zika virus (ZIKV) is a mosquito-borne flavivirus that predominantly circulates between humans and Aedes mosquitoes. Clinical studies have shown viruria in patients persists for an extended period, results infectious virions being excreted. Here, we demonstrate mosquitoes are permissive to ZIKV infection when breeding urine or sewage containing low concentrations of ZIKV. Mosquito larvae pupae, including from field aegypti can acquire contaminated aquatic systems, resulting adult females....
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused global destruction since its emergence in late 2019. Over the past years, virus continually evolved human hosts, thus leading to of variants with altered viral transmission, disease severity, and evasion immunity. Although vaccines for 2019 (COVID-19) have been developed at an unprecedented pace, posed a constant threat effectiveness approved vaccines. In this Commentary, we review key discuss their implications...
The SARS-CoV-2 Omicron subvariant BA.5 rapidly spread worldwide and replaced BA.1/BA.2 in many countries, becoming globally dominant. has unique amino acid substitutions the spike protein that both mediate immune escape from neutralizing antibodies produced by immunizations increase ACE2 receptor binding affinity. In a comprehensive, long-term (up to 9 months post primary vaccination), experimental vaccination study using male Syrian hamsters, we evaluate antibody responses efficacy against...
The intrinsic regulation of programmed death ligand-1 (PD-L1) expression remains unclear. Here, we report that zinc-finger protein 652 (ZNF652) is a potent transcription repressor PD-L1. ZNF652 frequently experiences loss heterozygosity (LOH) in various cancers. Higher LOH rate and lack estrogen-inducible lead to suppressed triple-negative breast cancer (TNBC). Mechanistically, physically associated with the NuRD co-repressor complex repress cohort genes, including Overexpression inhibits...
This study aims to investigate the role and mechanism of tubiquitin-conjugating enzyme E2 C (UBE2C) in acute myeloid leukemia (AML). Initially, UBE2C expression was analyzed using Cancer Genome Atlas database. Further, we silenced small-hairpin RNA (sh-RNA). detected via quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) Western blot analysis. Apoptotic events reactive oxygen species (ROS) levels were by flow cytometry. A xenograft model cells established, protein UBE2C,...
The persistent monkeypox outbreaks intensify the demand for vaccines. Based on mRNA vaccine platform, we conduct a systematic screening of virus (MPXV) surface proteins from two types viral particles, extracellular enveloped viruses (EVs) and intracellular mature (MVs). This unveils 12 important antigens with diverse levels neutralizing immunogenicity. Further assessment reveals that combinations 4, 8, these antigens, namely Mix-4, Mix-8, Mix-12, induce varying degrees immune protection,...
Abstract Thioredoxin reductase 1 (TrxR1) is a pivotal intracellular redox sensor and antioxidant enzyme. On the other hand, overexpression of TrxR1 closely correlated with initiation various tumors including breast cancer, though detailed mechanism remains unclear. Here we investigated role in dysplastic transformation human epithelial cell line MCF-10A induced by chronic oxidative stress. Not surprisingly, sustained exposure to H 2 O significantly augmented expression activity cells. The...
This study aimed to assess ethnic differences in health-related quality of life (HRQoL) among the rural elderly, and examine influence culture, residential segregation socioeconomic development on HRQoL. A total 6,511 elderly aged 60 years older from 5,541 households 116 villages across eight groups Guangxi Zhuang Autonomous region were selected assessed for The EQ-5D index values calculated based Chinese Time Trade-Off set. descriptive system scores, visual analogue scale described by...
Girdin is highly expressed in breast carcinomas. Suppression of inhibited cancer cell migration. However, the clinical implications as a marker are still unclear. Here we examined 80 specimens using immunohistochemistry. Overall, positive staining was 41.25% all cases. strongly tumors CerbB2-positive cancers (p < .05). Cases with both CerbB2- and Girdin-positive expression had higher histological grade than others. These findings indicated closed relationship between progression expression....
The Delta variant of SARS-CoV-2 has caused many breakthrough infections in fully vaccinated individuals. While vaccine status did not generally impact the number viral RNA genome copies nasopharyngeal swabs patients, as measured by Ct values, it been previously found to decrease infectious load symptomatic patients. We quantified RNA, virus, and anti-spike IgA collected from individuals asymptomatically infected with SARS-CoV-2. Vaccination decreased load, but amount RNA. Furthermore,...