A5041967567- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Cellular transport and secretion
- Virus-based gene therapy research
- Viral Infections and Vectors
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Vector-borne infectious diseases
- Cytokine Signaling Pathways and Interactions
- Lipid Membrane Structure and Behavior
- Photoreceptor and optogenetics research
- Mosquito-borne diseases and control
- RNA regulation and disease
Harvard University
2016-2025
Boston Children's Museum
2025
Boston Children's Hospital
2016-2025
Abstract After decades of inactivity throughout the Americas, western equine encephalitis virus (WEEV) recently re-emerged in South America, causing a large-scale outbreak humans and horses. WEEV binds protocadherin 10 (PCDH10) as receptor; however, nonpathogenic strains no longer bind human or PCDH10 but retain ability to avian receptors. Highly virulent can also very low-density lipoprotein receptor (VLDLR) apolipoprotein E 2 (ApoER2) alternative Here, by determining cryo-electron...
Western equine encephalitis virus (WEEV) is an arbovirus that historically caused large outbreaks of throughout the Americas. WEEV binds protocadherin 10 (PCDH10) as a receptor, and highly virulent ancestral strains also bind low-density lipoprotein receptor (LDLR)-related proteins. As declined human pathogen in North America over past century, isolates have lost ability to mammalian receptors while still recognizing avian receptors. To explain shifts dependencies assess risk re-emergence,...
The visual system is the best to study activity-dependent sensory circuit development. connections from retina dorsal lateral geniculate nucleus, retinogeniculate connections, undergo extensive remodeling during early postnatal life. Thus, techniques that allow expression of transgenes in developing are essential Here, we describe a protocol express genes-of-interest mouse via utero intraocular adeno-associated virus injections. For complete details on use and execution this protocol, please...