A5072826445- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacogenetics and Drug Metabolism
- Glutathione Transferases and Polymorphisms
- Inhalation and Respiratory Drug Delivery
- Drug Transport and Resistance Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Epilepsy research and treatment
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Cancer-related Molecular Pathways
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer, Lipids, and Metabolism
- Pharmaceutical studies and practices
- Free Radicals and Antioxidants
- Pneumonia and Respiratory Infections
- Drug-Induced Hepatotoxicity and Protection
- Acute Lymphoblastic Leukemia research
- Airway Management and Intubation Techniques
- Drug Solubulity and Delivery Systems
- Lipoproteins and Cardiovascular Health
- Autophagy in Disease and Therapy
- BRCA gene mutations in cancer
- Hormonal Regulation and Hypertension
- Cancer Genomics and Diagnostics
Purdue University West Lafayette
2020-2025
University of Pretoria
2024
University of Rajshahi
2024
Monash University
2017-2021
Australian Regenerative Medicine Institute
2017-2021
University of Dhaka
1999-2020
CARE Canada
2019
Imam Abdulrahman Bin Faisal University
2014
Comilla Medical College
1970-2013
Khulna University
2012
Dominant mutations in PIEZO2 , which codes for the principal mechanotransduction channel proprioception and touch sensation, have been found to cause different forms of distal arthrogryposis. Some observations suggest that these dominant induce a gain‐of‐function effect on channel. Here, we report consanguineous family with three siblings who showed short stature, scoliosis, gross motor impairment, progressive form contractures involving joints is distinct from patients . These also...
Abstract Background The alterations of biological markers are thought to be effective tools understand the pathophysiology and management major depressive disorder (MDD). A lot researches has implied many for depression, but any them fully discovered association between depression. present study investigated serum levels amino acids non-enzymatic antioxidants in also explained their with Methods This examined 247 MDD patients 248 healthy controls (HCs) matched by age sex. Hamilton Depression...
Background: Pseudomonas aeruginosa is one of the major pathogens that cause respiratory infections. The rise antimicrobial resistance has prompted a need for alternatives to conventional antibiotics. Bacteriophages (phages), natural predators bacteria, are gaining interest as an alternative therapeutic option against drug-resistant However, phage viability can be lost during manufacturing and delivery. Recent studies show phages taken up by lung epithelial cells, which makes fewer available...
Inhaled polymyxins are of considerable utility in achieving optimal exposure the respiratory tract for treatment lung infections caused by multidrug-resistant Gram-negative pathogens. Current inhaled polymyxin therapy is empirical, and often large doses used that may lead to potential pulmonary adverse effects. This study aimed investigate effect on human epithelial (A549) cells. The viability A549 cells was examined after with flow cytometry. Activation caspases 3, 8, 9, expression Fas...
Pharmacogenomic studies play a significant role in understanding the risk of breast cancer where genetic abnormalities are implicated as etiology cancer. Various polymorphisms tumor suppressor gene TP53 and E-cadherin (CDH1) have been found to be associated with increased worldwide. This study aimed analyze contribution CDH1 anomalies Bangladeshi patients. For determination, 310 patients 250 controls from women were recruited who matched up age use contraceptives Genetic detected by using...
Colistin therapy is used as the last line of defense against life-threatening Gram-negative infections. Nephrotoxicity major dose-limiting side effect that impedes optimal dosing patients. This study aims to examine nephroprotective plasma volume expander gelofusine colistin-induced nephrotoxicity. Renal protection was assessed in mice were subcutaneously injected with colistin sulfate (14 mg/kg body weight × 6 doses every 2 h; accumulated dose, 84 mg/kg) and simultaneously intraperitoneal...
Accumulation of polymyxins in the lung epithelial cells can lead to increased mitochondrial oxidative stress and pulmonary toxicity. Aminoglycosides are used, via intravenous delivery, against multidrug-resistant Gram-negative pathogens. Our recent vitro animal studies demonstrated that co-administration with aminoglycosides decreases polymyxin-induced The aim this study was investigate transport uptake polymyxin B tobramycin human Calu-3 mechanism reduced toxicity resulting from...
The rate of direct smoking, second hand and smokeless tobacco users as well the amount environmental pollutant like polycyclic aromatic hydrocarons is increasing in Bangladesh. Therefore, prevalence lung cancer day by day. To best our knowledge, no pharmacogentic study CYP3A4, CYP3A5 genes has been reported on Bangladeshi population relating those with cancer. present was conducted to determine association gene polymorphisms smoking development population. A case–control carried out 106...
The objective of this study was to determine whether p53 codon 47 and 72 polymorphisms are associated with increased risk lung cancer in Bangladeshi population. We carried out a case-control examined the genotype distribution Pro47Ser Arg72Pro single-nucleotide along tobacco smoking predisposition by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. included 106 patients 116 control subjects from Bangladesh. Lung estimated as odds ratio (OR) 95 %...
Objective: Increased extent of lipid peroxidation and decreased antioxidant defense has been postulated as a major contributor to the development preeclampsia. The present study was conducted determine serum level malondialdehyde (MDA) vitamin C in these patients. Methods: This research case–control assess status 150 preeclampsia patients 174 healthy pregnant women. Lipid assessed by measuring MDA level, evaluated for UV spectrophotometric method. Independent sample t test Pearson’s...
The extent to which cytochrome P450 (CYP) 2C19 genotype influences the effectiveness of clopidogrel remains uncertain due considerable heterogeneity between studies. We used polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method for genotyping loss function (LOF) allele, CYP2C19*2 and gain (GOF) CYP2C19*17 in 163 patients undergoing PCI 165 healthy volunteers from an ethnically distinctive Bangladeshi population. Thirty-eight took prasugrel 125 among whom 30 had...
To verify possible associations between polymorphisms of glutathione S-transferase Mu (GSTM1), θ (GSTT1) and Pi (GSTP1) genes susceptibility to lung cancer. A total 106 cancer patients 116 controls were enrolled in a case-control study. The GSTM1 GSTT1 analyzed using PCR while GSTP1 was PCR-restriction fragment length polymorphism. Risk estimated as odds ratio at 95% confidence interval unconditional logistic regression models adjusting for age, sex, tobacco use. null genotypes did not show...
Lung cancer is one of the most frequently occurring cancers throughout world as well in Bangladesh. This study aimed to correlate prognostic and/or predictive value functional polymorphisms SULT1A1 (rs9282861) and XRCC1 (rs25487) genes lung risk Bangladeshi population. A case-control was conducted which comprises 202 patients 242 healthy volunteers taking into account age, sex, smoking status. After isolation genomic DNA, genotyping done by polymerase chain reaction–restriction fragment...
Current inhaled polymyxin therapy is empirical and often large doses are administered, which can lead to pulmonary adverse effects. There a dearth of information on the mechanisms polymyxin-induced lung toxicity their intracellular localization in epithelial cells.To investigate polymyxins human A549 cells.A549 cells were treated with B organelles (early late endosomes, endoplasmic reticulum, mitochondria, lysosomes autophagosomes), ubiquitin protein visualized using immunostaining confocal...