Abstract Background The alterations of biological markers are thought to be effective tools understand the pathophysiology and management major depressive disorder (MDD). A lot researches has implied many for depression, but any them fully discovered association between depression. present study investigated serum levels amino acids non-enzymatic antioxidants in also explained their with Methods This examined 247 MDD patients 248 healthy controls (HCs) matched by age sex. Hamilton Depression...

Abnormal expression of inflammatory cytokines in major depressive disorder (MDD) suggests the activation an process. The pattern alterations cytokine levels is still ambiguous. present study aimed to evaluate interleukin-7 (IL-7) and interleukin-10 (IL-10) for their involvement pathophysiology MDD determine relationships with depression risk.The included 166 medication-free subjects: 84 patients 82 sex- age-matched healthy controls (HCs). A qualified psychiatrist diagnosed evaluated based on...

Abstract Objectives Major depressive disorder (MDD) is a distressing condition characterized by persistent low mood, loss of interest in daily activities. Researchers consider several biological, psycho-social, and genetic factors are involved depression. The present study aimed to investigate the serum levels monocyte chemoattractant protein-1 (MCP-1) MDD patients explore its role Methods This case-control recruited 114 106 healthy controls (HCs) matched age gender. A specialized...

Major depressive disorder is a leading heterogeneous psychiatric illness manifested by persistent low mood, feeling of sadness, and diminished interest in daily activities. Many biological, genetic, social factors are thought to be linked with depression. But any suitable early risk assessment markers absent for this illness. Therefore, we aimed investigate the serum levels IFN-γ major patients further association between cytokine depression.This prospective case-control study enrolled 120...

The social networking sites (SNS) are popular among people of all levels. Here we aimed to evaluate the relationship between use SNS and mental health young generation in Bangladesh. We conducted this cross-sectional study 791 subjects aged 15 40 years. Self-reported questionnaires were used collect demographics usage patterns respondents. have measured levels loneliness, depression, generalized anxiety, sleep disturbance using recommended assessment scales. estimations respondents 64%, 38%,...

Background Many studies have predicted major depressive disorder (MDD) as the leading cause of global health by 2030 due to its high prevalence, disability, and illness. However, actual pathophysiological mechanism behind depression is unknown. Scientists consider alterations in cytokines might be tools for understanding pathogenesis treatment MDD. Several past on several inflammatory cytokine expressions MDD reveal that an process activated, although precise causes changes levels are...

Abstract Background and Aims The ongoing public health emergency has created incredible fear of getting the infection a terrible psychological burden among all levels. pandemic severely affected private job holders' economic status lifestyle factors in Bangladesh. Here we aimed to assess depressive symptoms holders Bangladesh during Covid‐19 associated risk factors. Methods We conducted this online cross‐sectional survey between January 15, 2021, March 510 aged above 18 years. followed...

Major depressive disorder (MDD) is a complex mental health condition that results in several obstacles including disabilities, loss of productivity, and economic burdens on both patients society. Etiopathogenesis MDD involves factors such as sociodemographic, genetic, biological determinants. However, any suitable biomarkers for risk assessment depression have not been established yet. Alterations cytokine are assumed to be involved the pathophysiology severity disorder. Therefore, we aimed...

Major depressive disorder (MDD) is a heterogeneous mental having very diverse course and causing significant changes in daily life. Though the exact pathophysiology of depression still not known, an alteration serum levels cytokines neurotrophic factors was seen MDD subjects. In this study, we compared 'pro-inflammatory cytokine leptin factor EGF' healthy controls (HCs) patients. To make findings more accurate, eventually looked for correlation between altered EGF severity disease...

In the study, self emulsifying drug delivery system (SEDDS) of gliclazide, a poorly soluble drug, was developed and evaluated by in-vitro, ex-vivo in-vivo techniques. Oil surfactant were screened out according to their solubilizing capacity. Among tested components Transcutol HP Tween-80 showed good These two used in different ratios prepare gliclazide SEDDS. The SEDDS formulations transparent clear. Droplet size emulsion determined Laser Diffraction Technology Malvern. Formulation F1...

There is a lack of established biological, psychological, social, and digital markers for the prediction, identification, stratification patients with major depressive disorder (MDD). We therefore aimed to evaluate serum nerve growth factor (NGF) in MDD patients.In this case-control study, we recruited age- sex-matched healthy controls (HCs). A qualified psychiatrist evaluated study participants according Diagnostic Statistical Manual Mental Disorders, fifth edition. Serum NGF levels were...

Numerous earlier studies have stated an association between major depressive disorder (MDD) and altered expression of inflammatory process. However, it still needs to determine whether the alteration cytokines is causative factor or a consequence this disorder. Therefore, we attempted evaluate role pro-inflammatory cytokine IL-2 in pathophysiology depression.We collected blood samples from 111 MDD patients 112 healthy controls (HCs) matched by age sex. Diagnostic statistical manual mental...

Abstract Background Major Depressive Disorder (MDD) is a common mental ailment and the primary reason for disability. It manifests severe impact on moods, thoughts, physical health. At present, this disorder has become concern in field of public Alteration neurochemicals thought to be involved pathogenesis many psychiatric disorders. Therefore, we aimed evaluate serum IL-3 lipocalin-2 MDD patients healthy controls (HCs). Method We included total 376 participants study. Among them, 196 were...

Polymeric films of Eudragit RS 100 were prepared by solvent casting method to explore the possibilities using this polymer in transdermal therapeutic system (TTS). Naproxen was used as a model drug and incorporated two different percent loading (8.3 % w/w 20.8 films). Effects plasticizers ( PEG 1500 4000) release modifiers PVA HPMC 15cps) on vitro from naproxen loaded eudragit assessed. Drug found be function load, molecular weight physico-chemical property incorporated. At low highest...

Abstract Obsessive–compulsive disorder (OCD) is a mental condition that affects many people and characterized by recurring obsessions compulsions. It significantly impacts individuals’ ability to function ordinarily daily, affecting of all ages. This study aimed investigate whether or not the cytokines granulocyte macrophage colony-stimulating factor (GM-CSF) interleukin-17 (IL-17) are involved in pathophysiology OCD. A case–control with 50 OCD patients 38 healthy volunteers served as...

In the present study, a simple, sensitive and specific liquid chromatography (RP-HPLC) method has been developed validated for quantification of hydrochlorothiazide losartan potassium in tablet dosage form. A shim-pack CLC-ODS column (250 mm X 4.6 mm, 5μ mobile phase constituting 0.025 M phosphoric acid solution: acetonitrile (60:40 v/v, pH 3.0 adjusted with 80% acid) were used. The flow rate was 1.5 ml/min detection carried by using ultraviolet (UV) detector at wavelength 254 nm. retention...

A simple, selective and rapid reversed phase high performance liquid chromatographic (RPHPLC) method for the analysis of atenolol amlodipine in tablet has been developed validated. The system consisted a LC-20 AT pump, SPD-20 UV/visible detector. separation was achieved from C18 column at ambient temperature with mobile consisting methanol-acetonitrile buffer (solution ammonium acetate sodium pentanesulphonate ratio, 55:10:35 v/v, PH=3.00 adjusted phosphoric acid) flow rate 1ml/min retention...

The objective of this work was to formulate a Self Emulsifying Drug Delivery System (SEDDS) simvastatin, poorly soluble drug and evaluate by in vivo, vitro ex vivo techniques. Oils surfactants were screened out depending upon their solubilizing capacity. Among all the solvents, Capryol 90 showed good It dissolved 105 mg/ml simvastatin. Tween-80 also capacity which 117 mg/ml. two excipients used prepare simvastatin SEDDS. Formulations initially checked for color, clarity sedimentation. SEDDS...

Alprazolam is used as an anxiolytic drug for generalized anxiety disorder and it has been reported to produce sedation anterograde amnesia. In the current study, we randomly divided 26 healthy male volunteers into two groups: one group taking alprazolam 0.5 mg other placebo daily weeks. We utilized Cambridge Neuropsychological Test Automated Battery (CANTAB) software assess chronic effect of alprazolam. selected Paired Associates Learning (PAL) Delayed Matching Sample (DMS) tests memory,...

The article depicts a unique dataset of responses from 791 adults to self-made questionnaire five sections sent via Google survey tool (Google form) February 4, 2021, March 18, 2021 [1]. We collected for establishing paradigm the relationship between social networking sites (SNS) use and four dimensions psychological distress including depression, anxiety, loneliness, sleep disturbances. Facebook is most popular media in Bangladesh, we observed 669 users 122 non-Facebook-users aged 15 40...

Abstract Background The present work describes the development and validation of a new, specific, accurate, precise stability-indicating RP-HPLC method for simultaneous estimation Esomeprazole (ESP) Naproxen (NAP) in modified-release bi-layer tablet dosage form. Analytical Quality by Design concept was implemented through exercise to establish robustness method. Results Method performed on C18, 250 × 4.6 mm ID, 5 µm particle size column with 10 µl injection volume using photodiode array...