A5078694566- Computational Drug Discovery Methods
- Cancer, Stress, Anesthesia, and Immune Response
- Synthesis and biological activity
- Phytochemical compounds biological activities
- Cancer therapeutics and mechanisms
- Plant responses to water stress
- Essential Oils and Antimicrobial Activity
- Liver Disease Diagnosis and Treatment
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Lung Cancer Treatments and Mutations
- Traditional and Medicinal Uses of Annonaceae
- Analytical Methods in Pharmaceuticals
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Plant chemical constituents analysis
- SARS-CoV-2 and COVID-19 Research
- Natural product bioactivities and synthesis
- COVID-19 Clinical Research Studies
- Diverse Scientific Research Studies
- Cocoa and Sweet Potato Agronomy
- Andrographolide Research and Applications
- Analytical Chemistry and Chromatography
- Health and Lifestyle Studies
- Rice Cultivation and Yield Improvement
- Medicinal Plants and Neuroprotection
Monroe College
2023
University of Louisiana at Monroe
2018-2023
University of Bengkulu
2022
Kennesaw State University
2022
Northern University Bangladesh
2022
University of Dhaka
2022
Bangladesh Council of Scientific and Industrial Research
2022
Primeasia University
2022
University of Asia Pacific
2014-2022
The objective of this work was to formulate a Self Emulsifying Drug Delivery System (SEDDS) simvastatin, poorly soluble drug and evaluate by in vivo, vitro ex vivo techniques. Oils surfactants were screened out depending upon their solubilizing capacity. Among all the solvents, Capryol 90 showed good It dissolved 105 mg/ml simvastatin. Tween-80 also capacity which 117 mg/ml. two excipients used prepare simvastatin SEDDS. Formulations initially checked for color, clarity sedimentation. SEDDS...
A new dimeric prenylated quinolone alkaloid, named 2,11-didemethoxy-vepridimerine A, was isolated from the root bark of Zanthoxylum rhetsa, together with twelve known compounds. The structure compound elucidated on basis spectroscopic investigations (NMR and Mass). interaction compounds main protease SARS-CoV-2 (Mpro) evaluated using molecular docking followed by MD simulations. result suggests that compound, has highest negative binding affinity against Mpro a free energy −8.5 Kcal/mol,...
The current study was undertaken to provide scientific validation for the traditional medicinal applications of Ceriops decandra leaves in treating gastrointestinal disorders and inflammation. Additionally, aimed isolate a pure component from extracted further analysis. Lupeol crude methanolic extract by column chromatography as part phytochemical inquiry. Its structure determined using 1H 13C NMR spectroscopy. In order assess cytotoxicity, unrefined divided into two fractions: petroleum...
: diseases initiated by Coronavirus (CoV) have become the major public health problems worldwide in last two decades. The recent emergence of deadly COVID-19 due to SARS-CoV-2 has created unprecedented pandemic situations around globe making need for antiviral molecules treat it. Encountering conditions patients with synthetic shown some unpredictable results, including side effects. To face this complex situation, natural products can be good sources enormous treatment options fewer Wide...
Abstract A new dimeric prenylated quinolone alkaloid, named 2,11-didemethoxy-vepridimerine A, was isolated from the root bark of Zanthoxylum rhetsa , together with thirteen known compounds. The structure compound elucidated on basis spectroscopic investigations (NMR and Mass). interaction compounds main protease SARS-CoV-2 (Mpro) evaluated using molecular docking followed by MD simulations. result suggests that 2, 11-didemethoxy- vepridimerine has highest negative binding affinity against...
Abstract Epidemiological studies suggest that dietary intake of some natural products may be effective in reducing the risk breast cancer. Furthermore, various phytochemicals have been shown to interfere with cell signaling pathways involved regulating cancer proliferation and viability. γ-Tocotrienol is a isoform vitamin E displays potent anticancer activity against variety types at treatment doses little or no effect on normal growth Vitamin D3 an abundant phytochemical which also...
Abstract γ-Tocotrienol is a rare natural isoform of vitamin E that displays potent apoptotic and anti-metastatic activity against breast cancer. Galectin-3 protein plays an important role in metastasis by binding to glycoconjugates on receptors extracellular matrix proteins. Studies were conducted investigate the effects γ-tocotrienol galectin-3 expression highly malignant mouse +SA mammary tumor cells. Computer-aided molecular modeling studies carried out within active site based crystal...
Abstract Metastatic breast cancer is a leading cause of death women in the United States. The metastatic process involves epithelial cells losing their cellular polarity, adhesion to basement membrane, and acquiring migratory invasive properties. take on mesenchymal phenotype, hence this termed epithelial-to-mesenchymal transition (EMT). EMT characterized by reduction cell marker expression (E-cadherin, cytokeratin 8, 18), an increased markers (N-cadherin, vimentin, fibronectin). Previous...
The development of swamp rice varieties tolerant to submergence is an important step in reducing the impact floods that often occur swamplands. objective this study was evaluate response eight genotypes early stages tillering stress. experiment carried out using a completely randomized design with three replications. Pots filled soil were used as growing media and tarpaulin pond submerge plants. lines evaluated UBPR 2, 6, 7, 8, 10, 11 Inpari 30 variety resistance check Batang Piaman...
Dysentery is frequently associated with high morbidity and mortality found in young children mainly affects those developing nations. Rural people across the world trust on herbal remedies homeopathic medicines for their primary health care account of easy accessibility, efficacy exceptionally cost ampleness relation to modern drugs. The purpose present study was compile knowledge traditional healers indigenous Chittagong hill tracts, Bangladesh, including Rangamati, Bandarban Khagrachari...