Background Many studies have predicted major depressive disorder (MDD) as the leading cause of global health by 2030 due to its high prevalence, disability, and illness. However, actual pathophysiological mechanism behind depression is unknown. Scientists consider alterations in cytokines might be tools for understanding pathogenesis treatment MDD. Several past on several inflammatory cytokine expressions MDD reveal that an process activated, although precise causes changes levels are...

There is a lack of established biological, psychological, social, and digital markers for the prediction, identification, stratification patients with major depressive disorder (MDD). We therefore aimed to evaluate serum nerve growth factor (NGF) in MDD patients.In this case-control study, we recruited age- sex-matched healthy controls (HCs). A qualified psychiatrist evaluated study participants according Diagnostic Statistical Manual Mental Disorders, fifth edition. Serum NGF levels were...

Abstract Background Major Depressive Disorder (MDD) is a common mental ailment and the primary reason for disability. It manifests severe impact on moods, thoughts, physical health. At present, this disorder has become concern in field of public Alteration neurochemicals thought to be involved pathogenesis many psychiatric disorders. Therefore, we aimed evaluate serum IL-3 lipocalin-2 MDD patients healthy controls (HCs). Method We included total 376 participants study. Among them, 196 were...

Abstract Background Generalized anxiety disorder (GAD) is a devastating mental health condition characterized by constant, uncontrolled worrying. Recent hypotheses indicate that pro-inflammatory cytokines and chemokines are potential contributors to the pathogenesis of GAD. Here, we aimed assess role interleukin-2 (IL-2) interleukin-10 (IL-10) in pathophysiology development Methods This study recruited 50 GAD patients diagnosed according DSM-5 criteria 38 age-sex-matched healthy controls...

Abstract Background and Aims Major depressive disorder (MDD) is characterized by the occurrence of one or more episodes lasting a minimum 2 weeks marked persistently low mood lack enjoyment in daily activities. The diagnosis MDD not possible well‐established laboratory test biomarker. A wide range potential biomarkers for depression have been proposed many studies, but none them has adequately described correlation between depression. purpose this study was to evaluate serum interleukin‐1...

Social networking sites have changed the concept of social interaction and communication. There is increasing evidence using Facebook to express suicidal ideas feelings, predominantly among young people. Here, we report a series cases where victims committed suicide after sharing their thoughts feelings on posts or live-streaming. In present case series, observed most were teenagers adults. Usually, this group unwilling share with physicians other family members. At same time, they like...

Major depressive disorder (MDD) is the fourth biggest health-related concern that dramatically impacts individuals' mental and physical health. Alteration of serum proinflammatory cytokine levels may take part in development progression MDD. We aimed to explore compare role interleukin-12 (IL-12) MDD patients healthy controls (HCs) its involvement with disease severity.

The number of people suffering from mental illnesses has increased across the world.1-5 Mental health become an important issue than ever during ongoing Covid-19 pandemic.6-9 pandemic tremendously affected and life world. prevalence anxiety depression by 25% due to worldwide.10 European Union (EU) countries reported disorders ranging 16.1% 54.8% since beginning pandemic.11 Factors associated with poor in 26 were female sex, scarcity healthcare services, financial crisis, job loss Moreover, a...

Background: Suicide is a tragic and serious but preventable public health problem all over the world including Bangladesh. Committing suicide has become burning issue mortality rate increases especially in young females. Psychiatric evaluation needed attempted patients for better management plan to reduce such unnatural mortality, as well impairment related suicidal thought psychiatric disorders. Objectives: To assess disorders conditions that sufficient clinical attention among attempters...

Obsessive-compulsive disorder (OCD) is a prevalent mental health condition that impacts daily life. It thought to be associated with genetic, biological, and structural brain changes, serotonergic abnormalities, altered neuromodulation, environmental factors. Limited observational studies have examined cytokines in Bangladeshi patients OCD. This study aimed assess the levels of eotaxin-1 interleukin (IL)-34 individuals this disorder. case-control included 58 OCD 30 healthy controls (HCs)...

Substance abuse is one of the major public health issues throughout world that causing serious social and economical burden to different nations.The national co-morbidity survey in USA found year prevalence for drug misuse dependence (excluding alcohol) was 3.6%, whilst lifetime 11.9%. 1-The cost addictive illness Americans currently $144 billion per care jobloss. 2 In Europe as well our neighbor country India, scenario almost same.In Bangladesh, related problems are gradually becoming a...

Suicide is a perplexing phenomenon of taking one’s own life. Reasons behind suicide attempts are also unique. Clinical characteristics these patients have not been adequately studied from psychosocial and psychiatric point in Bangladesh. This study was aimed to assess the socio- demographic profile morbidities attempters. descriptive cross sectional conducted May 2017 September 2017. A total 101 were selected purposively who admitted following attempt different departments Rangpur Medical...

Previous studies have suggested the involvement of an activated inflammatory process in major depressive disorder (MDD), as altered expression cytokines is observed depression. This alteration can be cause or a consequence MDD. However, acknowledging prospective biomarkers would aid diagnosing guiding better therapeutic options. Therefore, we designed this study to assess macrophage migration inhibitory factor (MIF) depression.We collected blood samples from 115 MDD patients and 113 healthy...

The serum concentration of zinc, copper, manganese and lead in 30 manic patients human volunteers were determined by flame atomic absorption spectroscopy. It was observed that the zinc increased significantly (P < 0.05), where as concentrations found to be within limit > 0.05). These different trace elements may have some prognostic significance for diagnosis patients, but more work is suggested find out exact correlation between level & degree disorder patients.
 
 Key...

Necrophilia is a perverted sexual behavior where the perpetrator gets pleasure having sex with corpses. It rare perversion reported in journal or forensic literature. Here, we presented necrophiliac case of an adult male working morgue Bangladesh. The police arrested 20-year-old man from Dhaka, Bangladesh on charge necrophilia. He has been as assistant for last couple years and lived premises. Suddenly, lab report DNA profile indicated sperm found several dead bodies women were single man....

Generalized anxiety disorder (GAD) is a common and persistent mental illness accompanied by uncontrollable worries for daily staff. Physiological, environmental, genetic, stress from surroundings involved in developing GAD. Here, we aimed to assess the association of stromal cell-derived factor-1 (SDF-1) epidermal growth factor (EGF) pathophysiology GAD their role as diagnostic tools. This case-control study recruited 50 patients psychiatry department tertiary care teaching hospital Dhaka...

Background: Parental rejection plays an important role in individual's life at different stages of their development. Some types personality are the major predictors mental illness and individuals' maladjustment. Objective: The purpose present study was to explore possible relationship between parental adults context Bangladesh. Methods: A total 100 (39 male 61 female) participated this study. Their age range 18 60 years. They were selected from Department Psychiatry, Bangabandhu Sheikh...

This study was carried out in a private Intensive Care Unit (ICU) to assess the psychiatric morbidities and major problems patients requiring ICU. The most common diagnosis found be Depressive disorder followed by attention seeking behavior. Chemicals (organophosphorous, kerosene other medicine) were frequent agent used among suicide attempt patients. Keyword: Deliberate self harm, intensive care, mood disorders DOI:10.3329/jom.v11i1.4260 J Medicine 2010: 11: 7-11

Premature Ejaculation is one of the most common causes male sexual dysfunction with prevalence rate 20 % to 30% in different studies across world. ejaculation severe anxiety, embarrassment, and depression relational conflicts. Diagnosing can be problematic due multidimensional nature disease. Diagnostic Tool (PEDT) a psychometrically valid tool for this purpose. This was cross-sectional, analytical study conducted at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. The English...

The aim of this study was to determine the serum immunoglobulin concentration in both schizophrenic patients and healthy individuals. conducted with 30 (thirty) (24 males 6 females, aged 55.4±13.0 years); age gender-matched, control subjects were enrolled. An enzyme-linked immunosorbent assay (ELISA) employed analyze concentrations. Results showed that concentrations IgG, IgM IgA not changed significantly than cohort controls. IgG level found be 15.23 ± 3.82 g/l (p = 0.341) patients, while...