A5064670990- Natural Antidiabetic Agents Studies
- Metabolomics and Mass Spectrometry Studies
- Alkaloids: synthesis and pharmacology
- Ethnobotanical and Medicinal Plants Studies
- Biological Stains and Phytochemicals
- Traditional and Medicinal Uses of Annonaceae
- Essential Oils and Antimicrobial Activity
- Computational Drug Discovery Methods
- Plant-Derived Bioactive Compounds
- Phytochemistry and Biological Activities
- Free Radicals and Antioxidants
- Advances in Cucurbitaceae Research
- Obesity, Physical Activity, Diet
- Agricultural Economics and Practices
- Protein Interaction Studies and Fluorescence Analysis
- Mangiferin and Mango Extracts
- Sirtuins and Resveratrol in Medicine
- Ginger and Zingiberaceae research
- Bioactive natural compounds
- Spectroscopy and Chemometric Analyses
- Advanced Drug Delivery Systems
- Medicinal Plants and Neuroprotection
- Drug-Induced Hepatotoxicity and Protection
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
University of Chittagong
2016-2024
International Islamic University Malaysia
2019-2021
University of Asia Pacific
2013
In the study, self emulsifying drug delivery system (SEDDS) of gliclazide, a poorly soluble drug, was developed and evaluated by in-vitro, ex-vivo in-vivo techniques. Oil surfactant were screened out according to their solubilizing capacity. Among tested components Transcutol HP Tween-80 showed good These two used in different ratios prepare gliclazide SEDDS. The SEDDS formulations transparent clear. Droplet size emulsion determined Laser Diffraction Technology Malvern. Formulation F1...
This research aims to study the target specificity of selective bioactive compounds in complexing with human angiotensin-converting enzyme (hACE2) receptor impede severe acute respiratory syndrome coronavirus 2 influx mechanism resulting cardiac injury and depending on receptor's active site properties quantum tunneling.A library 120 phytochemical ligands was prepared, from which 5 were selected considering their absorption, distribution, metabolism, excretion (ADMET) quantitative...
Jack leaf, known in Indonesia as "daun salung", is traditionally used for the treatment of diabetes and other diseases. Despite its potential, phytochemical study related to anti-diabetic activity still lacking. Thus, this aimed identify putative inhibitors α-glucosidase, a prominent enzyme contributing type 2
This plant is very popular ingredient of local made drinks during hot summer. After drinking this drink people feels fresh, relaxed and can enjoy sound sleep. Present study was aimed to assess the sedative properties a Sterculia villosa leaves. Therefore, we tried find out methanolic extract from leaves having any activity or not.The were subjected various in vivo methods like hole cross test, open field elevated plus-maze (EPM) thiopental sodium induced sleeping time test. Diazepam used as...
Psychotria malayana Jack has traditionally been used to treat diabetes. Despite its potential, the scientific proof in relation this plant is still lacking. Thus, present study aimed investigate α-glucosidase inhibitors P.malayana leaf extracts using a metabolomics approach and elucidate ligand–protein interactions through silico techniques. The leaves were extracted with methanol water at five various ratios (100, 75, 50, 25 0% v/v; water–methanol). Each extract was tested for inhibition,...
Coelogyne suaveolens has been used as a traditional medicine for many years, and its potential natural source of antibacterial agents is great interest. This investigation aimed to identify the bioactive compounds in plant extract assess their properties. To achieve this, we identified using Gas chromatography mass spectrometry (GCMS) analysis on extract's ethyl acetate fraction disc diffusion method determine effect. Additionally, molecular docking were performed predict binding affinities...
Psychotria malayana Jack belongs to the Rubiacea and is widespread in Southeast Asian countries. It traditionally used treat diabetes. Despite its potential medicinal use, scientific proof of this pharmacological action toxic effect plant are still lacking. Hence, study aimed investigate vitro antidiabetic antioxidant activities, toxicity, preliminary phytochemical screening P. leaf extracts by gas chromatography-mass spectrometry (GC-MS) after derivatization. The activities different were...
The plant Psychotria malayana Jack belongs to the Rubiaceae family and is known in Malaysia as “meroyan sakat/salung”. A rapid analytical technique facilitate evaluation of P. leaves’ quality has not been well-established yet. This work aimed therefore develop a validated order predict alpha-glucosidase inhibitory action (AGI) leaves, applying Fourier Transform Infrared Spectroscopy (FTIR) fingerprint utilizing an orthogonal partial least square (OPLS). dried leaf extracts were prepared by...
ABSTRACT Caesalpinia digyna (Family: Fabaceae) is traditionally used in Ayurvedic medicine for various medicinal purposes, including as a treatment wounds, leprosy, skin diseases, fever, diabetes, etc. Although the root and stem of this plant have significant value, there was little research on leaves plant. This study aimed to investigate qualitative phytochemical profile evaluate vitro cytotoxic, anti‐inflammatory, antioxidant, antiarthritic activities, well vivo anti‐inflammatory...
Psychotria malayana Jack (Family: Rubiaceae, local name: Salung) is a traditional herb used to treat diabetes. A previous study by our research group demonstrated that P. methanolic and water extract exhibits significant potential as an effective agent for managing Further has been performed on the extraction optimization of this plant enhance its inhibitory activity against α-glucosidase, key enzyme associated with diabetes, reduce toxicity. The objectives are evaluate anti-diabetic,...
Consumption of takeaway and fast food by young adolescents is no longer confined to the developed countries; it has spread developing countries as well.The culture consumption replaced traditional meal among university students a great public health concern.Excessive responsible for obesity epidemics cause dramatic increase obesity-related diseases.A cross-sectional study was carried out from March December, 2015 attending in five established Universities Bangladesh,
Metabolite profiling is required to reveal bioactive chemicals in ginger rhizome for supporting its traditional claim as anti-diabetic agent. This study aimed evaluate α-glucosidase inhibitory (AGI) and antioxidant activities of the rhizome, identify putative inhibitors, analyse protein-ligand interaction inhibitors. The extracts were tested
Bezoar (PB) is a rare, solidified form of undigested food commonly found in the gastrointestinal tract porcupine (Hystrix brachyura). It believed to be traditionally used treat various diseases including different kinds cancers Malaysia. However, its active principles have not been out yet. The purpose this study was investigate anticancer property PB extract as well identify metabolites responsible for effect through widely acclaimed metabolomics approach. Initially, 25 extracts using...
There are only 22 pharmaceutical companies out of 151 in Bangladesh producing quality product maintaining the cGMP, where mor e than 40 manufacturing Losartan Potassium 50 mg tablets.So, clinicians and pharmacists facing difficulty to choose a suitable brand or alternative use.The aim present study was predict bioequivalence four top ranked brands tablets marketed using In Vitro tests.The dissolution carried with five according FDA method.The process done for 12 each brand; 900 ml pH 1.2 0.1...
Background: Brassica oleracea L. var. italic conjointly known as “broccoli” is a crucial ayurvedic medication in traditional medicine mostly cultivated Italy, France, England and USA. The aim of the present research work was to determine antidiabetic, analgesic, antioxidant antimicrobial potentials fruits shoots broccoli.
 Methods: In this study, antidiabetic activity investigated using alloxan induced diabetic model. Analgesic manifested acetic acid-induced writhing reflex. Antioxidant...
Hystrix brachyurabezoar is calcified undigested material found in the gastrointestinal tract known for various medicinal benefits including as an anticancer agent. However, H. brachyurapopulation has been declining due to its demand and under Malaysian law protection. Therefore, present study aimed identify bezoar active compounds through metabolomics in-silico approaches. Five replicates of powder were subjected extraction using different solvent ratios methanol-water (100, 75, 50, 25, 0%...