A5036843968- Inhalation and Respiratory Drug Delivery
- Advanced Drug Delivery Systems
- Nanoparticle-Based Drug Delivery
- biodegradable polymer synthesis and properties
- Microencapsulation and Drying Processes
- Aerosol Filtration and Electrostatic Precipitation
- Neonatal Respiratory Health Research
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- Antimicrobial agents and applications
- Electrohydrodynamics and Fluid Dynamics
- Advancements in Transdermal Drug Delivery
- Polymer Surface Interaction Studies
- Microfluidic and Bio-sensing Technologies
- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Asthma and respiratory diseases
- Microfluidic and Capillary Electrophoresis Applications
- Particle Dynamics in Fluid Flows
- Pulmonary Hypertension Research and Treatments
- Nanoparticles: synthesis and applications
- Lipid Membrane Structure and Behavior
- Advanced Polymer Synthesis and Characterization
Merck (Germany)
2019-2025
Philipps University of Marburg
2012-2024
Justus-Liebig-Universität Gießen
2011-2024
Bayer (Germany)
2016-2020
Institut Galien Paris-Saclay
2014-2017
Université Paris-Sud
2014-2017
Centre National de la Recherche Scientifique
2015
Université Paris-Saclay
2015
Universities of Giessen and Marburg Lung Center
2015
Giessen School of Theology
2013
Amphiphilic triblock copolymers represent a versatile delivery platform capable of co-delivery nucleic acids, drugs, and/or dyes. Multifunctional cationic based on poly(ethylene glycol), poly-ε-caprolactone, and polyethylene imine, designed for the siRNA, were evaluated in vitro vivo. Moreover, acid-unpacking-sensitive imaging technique quantum dot-mediated fluorescence resonance energy transfer (QD-FRET) was established. Cell uptake measured by flow cytometry, whereas transfection...
Polymer nanoparticles (NPs) offer versatile novel biological features of interest for drug delivery applications. "Ouzo diagrams" allowed a systematic manufacture specified colloidal formulations by the widely used nanoprecipitation process. Surprisingly, despite well-documented relevance applied organic solvent nanoprecipitation, its effect on actual status region" was so far not studied. Herein, investigations were undertaken to account potential impact type poly(lactide-co-glycolide)...
Aerosol therapy using particulate drug carriers has become an increasingly attractive method to deliver therapeutic or diagnostic compounds the lung. Polymeric nanoparticles are widely investigated in nanomedicine. The targeted and controlled release of drugs from for pulmonary delivery, however, is a research field that been so far rather unexploited. Therefore, objective this study was compare absorption distribution characteristics salbutamol after aerosolization as solution entrapped...
Abstract Novel ‘nano in nano’ composites consisting of biodegradable polymer nanoparticles incorporated into nanofibers may efficiently modulate drug delivery. This is shown here using a combination model compound‐loaded encapsulated electrospun fibers. The dye coumarin 6 used as compound for order to simulate release from loaded poly(lactide ‐co‐ glycolide) nanoparticles. Dye the occurs immediately aqueous solution. Dye‐loaded which are by display significantly retarded release. magnified image