A5078209528- Hearing, Cochlea, Tinnitus, Genetics
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Marine animal studies overview
- Congenital heart defects research
- Pesticide and Herbicide Environmental Studies
- Ionic liquids properties and applications
- Sepsis Diagnosis and Treatment
- Machine Learning in Bioinformatics
- Biochemical Analysis and Sensing Techniques
- Wastewater Treatment and Nitrogen Removal
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Glutathione Transferases and Polymorphisms
- Toxic Organic Pollutants Impact
- Connexins and lens biology
- Venous Thromboembolism Diagnosis and Management
- Industrial Technology and Control Systems
- Animal Vocal Communication and Behavior
- Cancer-related gene regulation
- Underwater Vehicles and Communication Systems
- ERP Systems Implementation and Impact
- Manufacturing Process and Optimization
- Chromium effects and bioremediation
- Microbial bioremediation and biosurfactants
Guiyang Medical University
2022-2024
Case Western Reserve University
2017-2021
University School
2017-2021
Ocean University of China
2012-2013
Hefei General Machinery Research Institute (China)
2009-2011
Detection of water motion by the lateral line relies on mechanotransduction complexes at stereocilia tips. This sensory system is comprised neuromasts, patches hair cells with stereociliary bundles arranged morphological mirror symmetry that are mechanically responsive to two opposing directions. Here, we find transmembrane channel-like 2b (Tmc2b) differentially required for in zebrafish line. Despite similarities neuromast cell morphology, three classes these can be distinguished their...
Aging | doi:10.18632/aging.205563. Chaofen Zhao, Lina Liu, Qianyong He, Yuanyuan Li, Jianglong Feng, Yue Chen, Yuxin Xinyu Xu, Shaoyuan Zhu, Yuanmei Ye, Yajing Wen, Zhirui Zeng, Ding'an Zhou, Feng Jin
Abstract Perception of sound is initiated by mechanically gated ion channels at the tips stereocilia. Mature mammalian auditory hair cells require transmembrane channel-like 1 (TMC1) for mechanotransduction, and mutations cognate genetic sequences result in dominant or recessive heritable deafness forms humans mice. In contrast, zebrafish lateral line cells, which detect water motion, Tmc2a Tmc2b. Here, we use standard multiplex genome editing conjunction with functional behavioral assays to...
Hair cells are heterogenous, enabling varied roles in sensory systems. An emerging hypothesis is that the transmembrane channel-like (Tmc) proteins of hair cell’s mechanotransduction apparatus vary within and between organs to permit encoding different mechanical stimuli. Five anatomical variables may coincide with Tmc use by a cell ear containing organ, morphology, position an axis best sensitivity for cell, bundle’s orientation this axis. Here, we test zebrafish using suite genetic...
Hearing impairment (HI) is a common disorder of sensorineural function with highly heterogeneous genetic background. Although substantial progress has been made in the understanding etiology hereditary HI, many genes implicated HI remain undiscovered. Via exome and Sanger sequencing DNA samples obtained from consanguineous Pakistani families that segregate profound prelingual we identified rare homozygous missense variants four (ADAMTS1, MPDZ, MVD, SEZ6) are likely underlying cause HI....
Objectives Platelet count is an independent predictor of mortality in patients with cancer. It remains unknown whether the platelet related to in-hospital severely ill tumours. Design A retrospective study based on a dataset from multicentre cohort. Setting This was secondary analysis data one Electronic Intensive Care Unit Collaborative Research Database survey cycle (2014–2015). Participants The pertaining tumours were collected 208 hospitals located across USA. initially total 200 859...
To enable hearing, the sensory hair cell contains specialized subcellular structures at its apical region, including actin-rich cuticular plate and circumferential band. ACF7 (actin crosslinking family protein 7), encoded by gene Macf1 (microtubule actin factor 1), is a large cytoskeletal that interacts with microtubules filamentous to shape cells. localizes band in cells of vertebrates. The compelling expression pattern cells, combined conserved roles this cytoskeleton various types...