A5087175312- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Single-cell and spatial transcriptomics
- Colorectal Cancer Surgical Treatments
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Advanced Image Fusion Techniques
- Radiomics and Machine Learning in Medical Imaging
- Image and Signal Denoising Methods
- Immunotherapy and Immune Responses
University of Oxford
2023-2024
Centre for Human Genetics
2024
BackgroundTumour-infiltrating CD8+ cytotoxic T cells confer favourable prognosis in colorectal cancer. The added prognostic value of other infiltrating immune is unclear and so we sought to investigate their two large clinical trial cohorts.MethodsWe used multiplex immunofluorescent staining tissue microarrays assess the densities CD8+, CD20+, FoxP3+, CD68+ intraepithelial intrastromal compartments from tumour samples patients with stage II–III cancer SCOT (ISRCTN59757862), which examined 3...
Abstract Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers tumour immunoprofiling. However, application at scale to clinical trial samples sourced from institutions is challenging due pre‐analytical heterogeneity. This study reports an analytical approach the largest multi‐parameter immunoprofiling of date. We analysed 12,592 tissue microarray (TMA) spots 3,545 colorectal cancers more than 240 in two trials...
ABSTRACT Multiplex immunofluorescence (mIF) imaging can provide comprehensive quantitative and spatial information for multiple immune markers tumour immunoprofiling. However, application at scale to clinical trial samples sourced from institutions is challenging due pre-analytical heterogeneity. This study reports an analytical approach the largest multiparameter immunoprofiling of date. We analysed 12,592 tissue microarray (TMA) spots 3,545 colorectal cancers (CRC) more than 240 in two...