A5101657797- Trypanosoma species research and implications
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Lysosomal Storage Disorders Research
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Research on Leishmaniasis Studies
- Diet and metabolism studies
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
University of Zurich
2024
University Hospital of Zurich
2024
University of South Bohemia in České Budějovice
2021-2022
Clinical Research Center Kiel
2016
Abstract Background Advancements in access to antiretroviral therapy (ART) and human immunodeficiency virus (HIV) care have led a decline AIDS-related deaths among people with HIV (PWH) Switzerland. However, data on the ongoing changes causes of death PWH over past 15 years are scarce. Methods We investigated all reported Swiss Cohort Study between 2005 2022. Causes were categorized using Coding Death protocol. The statistical analysis included demographic stratification identify time trends...
A growing number of case reports have described tenofovir (TDF)-related proximal renal tubulopathy and impaired calculated glomerular filtration rates (cGFR). We assessed TDF-associated changes in cGFR a large observational HIV cohort.We compared treatment-naive patients or with treatment interruptions > = 12 months starting either TDF-based combination antiretroviral therapy (cART) (n 363) TDF-sparing regime 715). The predefined primary endpoint was the time to 10 ml/min reduction cGFR,...
Kinesins are motor proteins found in all eukaryotic lineages that move along microtubules to mediate cellular processes such as mitosis and intracellular transport. In trypanosomatids, the kinesin superfamily has undergone a prominent expansion, resulting one of most diverse repertoires includes two kinetoplastid-restricted families X1 X2. Here, we characterize Trypanosoma brucei TbKifX2A, an orphaned X2 kinesin. TbKifX2A tightly interacts with TbPH1, kinesin-like protein likely inactive...
Introduction: Obesity is associated with adipose tissue inflammation. Wnt5a has recently been described as a novel cytokine in metabolic The aim of the present study was to examine, if stimulation Ω-3-fatty acid receptor GPR120 might be able inhibit wnt5a release from activated macrophages, which indicate therapeutic target for future diabetes therapy.
ABSTRACT Kinesins are motor proteins found in all eukaryotic lineages that move along microtubules to mediate cellular processes such as mitosis and intracellular transport. In trypanosomatids, the kinesin superfamily has undergone a prominent expansion, resulting one of most diverse repertoires includes two kinetoplastid-restricted families X1 X2. Here, we characterize Trypanosoma brucei TbKifX2A, an orphaned X2 kinesin. TbKifX2A tightly interacts with TbPH1, kinesin-like protein likely...