A5076131467- Immune Cell Function and Interaction
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Migration, Health and Trauma
- Healthcare Systems and Reforms
- HIV/AIDS Impact and Responses
- Tuberculosis Research and Epidemiology
- Global Public Health Policies and Epidemiology
- Global Health Workforce Issues
- Mycobacterium research and diagnosis
- Chronic Disease Management Strategies
- Organometallic Complex Synthesis and Catalysis
- Catalytic Cross-Coupling Reactions
- Asymmetric Hydrogenation and Catalysis
- Genomics and Rare Diseases
- Health and Conflict Studies
Médecins Sans Frontières
2018
ETH Zurich
2005-2014
TuBerculosis Vaccine Initiative
2013
Institute of Microbiology
2004
UNSW Sydney
2003
The University of Sydney
2003
Tackling the high non-communicable disease (NCD) burden among Syrian refugees poses a challenge to humanitarian actors and host countries. Current response priorities are identification integration of key interventions for NCD care into programs as well sustainable financing. To provide evidence effective intervention planning, we conducted cross-sectional survey non-camp in northern Jordan investigate determinants NCDs prevalence multi-morbidities assess access care. We used two-stage...
ABSTRACT Progressive human immunodeficiency virus type 1 (HIV-1) infection is often associated with high plasma load (pVL) and impaired CD8 + T-cell function; in contrast, T cells remain polyfunctional long-term nonprogressors. However, it still unclear whether dysfunction the cause or consequence of pVLs. Here, we conducted a longitudinal functional phenotypic analysis virus-specific cohort patients chronic HIV-1 infection. During initiation maintenance successful antiretroviral therapy...
In persistent viral infections, the host's immune system is challenged by constant exposure to antigen, potentially causing continuous activation of CD8 + T cells with subsequent immunopathology. Here we demonstrate, for experimental chronic lymphocytic choriomeningitis virus and human HIV infection, that upon prolonged in vivo TCR-triggered Ca 2+ flux, degranulation, cytotoxicity are maintained on a cellular level, whereas cytokine production severely impaired because selective defect...
The syntheses of five cationic iridium(I) complexes, containing the bidentate ligands bis(1-pyrazolyl)methane (BPM) and bis(3,5-dimethyl-1-pyrazolyl)methane (dmBPM), {[Ir(BPM)(COD)]+(BPh4)-} (1), {[Ir(dmBPM)(COD)]+(BPh4)-} (2), {[Ir(BPM)(COD)]+[Ir(COD)Cl2]-} (4), {[Ir(BPM)(CO)2]+(BPh4)-} (3), {[Ir(dmBPM)(CO)2]+(BPh4)-} (5), are reported. complexes were characterized by NMR spectroscopy, solid-state structure (3) was determined single-crystal X-ray crystallographic analysis. (5) effective...
Isolated primary human cells from different donors vary in their permissiveness-the ability of to be infected and sustain the replication immunodeficiency virus type 1 (HIV-1). We used replicating HIV-1 single-cycle lentivirus vectors a population approach identify polymorphic steps during viral replication. found that phytohemagglutinin-stimulated CD4(+) CD45RO(+) CD57(-) T healthy blood (n = 128) exhibited 5.2-log-unit range production. For 20 selected representing spectrum CD4 T-cell...
Progressive quantitative and qualitative decline of CD4(+) T cell responses is one hallmark HIV-1 infection likely depends on several factors, including a possible contribution by the envelope glycoprotein gp120, which binds with high affinity to CD4 receptor. Besides virion-associated cell-expressed considerable amounts soluble gp120 are found in plasma or lymphoid tissue, predominantly form gp120-anti-gp120 immune complexes (ICs). Because functional consequences binding cells...