A5004654408- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Computational Fluid Dynamics and Aerodynamics
- Gas Dynamics and Kinetic Theory
- Immune cells in cancer
- Fluid Dynamics and Turbulent Flows
- Long-Term Effects of COVID-19
- Glioma Diagnosis and Treatment
- Animal Behavior and Reproduction
- Neonatal Respiratory Health Research
- Fish Ecology and Management Studies
- Zebrafish Biomedical Research Applications
- Respiratory viral infections research
- Phagocytosis and Immune Regulation
- Cancer therapeutics and mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Neuroblastoma Research and Treatments
- Viral-associated cancers and disorders
- Lymphadenopathy Diagnosis and Analysis
- Autoimmune Bullous Skin Diseases
- Inhalation and Respiratory Drug Delivery
University of Basel
2021-2025
University Hospital of Basel
2021-2025
The Geneva Association
2019
ETH Zurich
2018-2019
A patient-tailored, ex vivo drug response platform for glioblastoma (GBM) would facilitate therapy planning, provide insights into treatment-induced mechanisms in the immune tumor microenvironment (iTME), and enable discovery of biomarkers response. We cultured regionally annotated GBM explants perfusion bioreactors to assess iTME responses immunotherapy. Explants were treated with anti-CD47, anti–PD-1, or their combination, analyzed by multiplexed microscopy [CO-Detection indEXing (CODEX)],...
BackgroundToll-like receptors (TLRs) play a pivotal role in the immunologic response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Exaggerated inflammatory of innate immune cells, however, may drive morbidity and death Coronavirus disease 19 (COVID-19).ObjectiveWe investigated engagement SARS-CoV-2 with TLR4 order better understand how tackle hyperinflammation COVID-19.MethodsWe combined RNA-sequencing data human lung tissue bronchoalveolar lavage fluid cells...
Summary Post‐transplant lymphoproliferative disorders (PTLD) and lymphomas in immunocompromised individuals represent significant clinical challenges, with a limited understanding of their pathogenesis. We investigated PTLD cohort ( n = 50) consisting ‘early lesions’ (infectious mononucleosis‐like PTLD, plasmacytic follicular hyperplasias), polymorphic post‐transplant diffuse large B‐cell (PT‐DLBCL). The study also included 15 DLBCL autoimmune/immunocompromised backgrounds (IS‐DLBCL) 14...
Rationale: Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors. Objectives: To assess whether IgA autoantibodies target lung-specific proteins and contribute severity. Methods: We collected 147 blood, 9 lung tissue, 36 BAL fluid samples from three tertiary hospitals in Switzerland one Germany. Severe COVID-19 was defined by the need...
Liver injury after COVID-19 vaccination is very rare and shows clinical histomorphological similarities with autoimmune hepatitis (AIH). Little known about the pathophysiology of vaccine-induced liver (VILI) its relationship to AIH. Therefore, we compared VILI AIH.Formalin-fixed paraffin-embedded biopsy samples from patients (n = 6) an initial diagnosis AIH 9) were included. Both cohorts by evaluation, whole-transcriptome spatial transcriptome sequencing, multiplex immunofluorescence, immune...
Abstract The analysis of larval zebrafish locomotor behavior has emerged as a powerful indicator perturbations in the nervous system and is used many fields research, including neuroscience, toxicology drug discovery. however, highly variable, resulting use large numbers animals inability to detect small effects. In this study, we analyzed whether individual stable over development behavioral parameters correlate with physiological morphological features, aim better understanding variability...
Although initial immunophenotypical studies on peripheral blood and bronchoalveolar lavage samples have provided a glimpse into the immunopathology of COVID-19, analyses pulmonary draining lymph nodes are currently scarce. 22 lethal COVID-19 cases 28 controls were enrolled in this study. Pulmonary (mediastinal, tracheal, peribronchial) collected at autopsy. Control selected from range histomorphological sequelae [unremarkable histology, infectious mononucleosis, follicular hyperplasia,...
<b><i>Background:</i></b> Transcriptomic data on bronchoalveolar lavage (BAL) from COVID-19 patients are currently scarce. <b><i>Objectives:</i></b> This case series seeks to characterize the intra-alveolar immunopathology of COVID-19. <b><i>Method:</i></b> BALs were performed 14 (5 COVID-19, which 3 mild and 2 largely asymptomatic, 9 controls). Controls included asthma (<i>n</i> = 1), unremarkable 3),...
Stable numerical simulations for a hyperbolic system of conservation laws relaxation type but not in divergence form are obtained by incorporating the physical entropy into simulations. The balance is utilized as an additional equation to eliminate numerically critical terms with simple substitutions. method has potential wider applicability than particular example presented here.
One of the major challenges in extending hydrodynamics to far from equilibrium gas flows comes with need new boundary conditions for any modeling approach. The difficulty lies finding an accurate set physical at which simultaneously form a well-posed system equations. In this paper, we study moment equations rarefied that equipped entropy. This allows straightforward derivation are consistent mathematical requirements system. complete nonlinear is simulated channel flow setting and compared...
ABSTRACT Complications affecting the lung are hallmarks of severe coronavirus disease 2019 (COVID-19). While there is evidence for autoimmunity in COVID-19, exact mechanisms remain unknown. Here, we established a prospective observational cohort to study specific autoantibodies (auto-Abs). Incubation plasma from COVID-19 patients with healthy human tissue revealed presence IgA antibodies binding surfactant-producing pneumocytes. Enzyme-linked immunosorbent assays (ELISA) and protein...
Since angiotensin converting enzyme-2 (ACE2) was discovered as an essential entry factor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), there has been conflicting evidence regarding the role renin-angiotensin-aldosterone system (RAAS) in COVID-19. This study elucidates pulmonary expression patterns factors (ACE2 and transmembrane protease serine subtype 2, TMPRSS2) RAAS components lethal COVID-19.Lung tissue from COVID-19 autopsies (n = 27) controls 23) underwent...
Abstract Recent therapeutic strategies for glioblastoma (GBM) aim at targeting immune tumor microenvironment (iTME) components to induce antitumoral immunity. A patient-tailored, ex vivo drug testing and response analysis platform GBM would facilitate personalized therapy planning, provide insights into treatment-induced mechanisms in the iTME, enable discovery of biomarkers resistance. We cultured 47 explants from center periphery 7 patients perfusion bioreactors assess iTME responses...
Abstract The analysis of larval zebrafish locomotor behavior has emerged as a powerful indicator perturbations in the nervous system and is used many fields research, such neuroscience, toxicology or drug discovery. zebrafish, however, highly variable, resulting use high numbers animals inability to detect small effects. In this study, we analyzed whether individual stable over development behavioral parameters correlate with physiological morphological features larvae, aim better understand...
Abstract COVID-19 is a respiratory-centered systemic disorder caused by the severe acute respiratory syndrome (SARS-CoV-2) virus. The disease can progress into form causing lung injury (ALI), mainly diffuse alveolar damage (DAD) with thromboinflammation, immunopathology, and cytokine storm. CD48 an activating/co-activating receptor expressed on most hematopoietic cells, existing as both membrane-bound (mCD48) soluble (sCD48) forms. Its high-affinity ligand 2B4 (CD244). We previously found...
mRNA-based vaccines against SARS-CoV-2 have been proven to be very efficient in preventing severe COVID-19. Temporary lymphadenopathy (LA) has observed as a common adverse event following immunization. Here we describe case series of three female patients with prominent local generalized LA after mRNA-1273 vaccination, which led lymph node biopsy due the suspicion lymphoma or metastasis. All morphologically showed similar patterns follicular hyperplasia and especially extrafollicular blast...
Abstract COVID-19 is a respiratory-centered systemic disorder caused by SARS-CoV-2. The disease can progress into severe form causing acute lung injury. CD48 co-signaling receptor, existing as both membrane-bound and soluble forms reported to be dysregulated in several inflammatory conditions. Therefore, we reasoned that could deregulated well. Here analyzed expression autoptic sections peripheral blood leukocytes sera of patients gene profiling (HTG® autoimmune panel), immunohistochemistry,...
Abstract The immune tumor microenvironment (iTME) of glioblastoma (GBM) contains microglial, macrophage, other myeloid cell populations and as adaptive cells. Recent therapeutic strategies for GBM aim at targeting iTME components to induce antitumoral immunity. A patient-tailored, ex vivo drug testing response analysis platform would facilitate personalized therapy planning, provide insights into treatment-induced mechanisms in the iTME, enable discovery biomarkers resistance. Here, we...