A5006977080- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cardiovascular Effects of Exercise
- MicroRNA in disease regulation
- Retinal Development and Disorders
- Viral Infections and Immunology Research
- Ocular Oncology and Treatments
- RNA and protein synthesis mechanisms
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Signaling Pathways in Disease
- Cardiomyopathy and Myosin Studies
- Cancer-related molecular mechanisms research
- Cardiac electrophysiology and arrhythmias
- Sports injuries and prevention
- Zebrafish Biomedical Research Applications
Maastricht University
2019-2023
Ghent University
2016
Abstract Retinoblastoma is a pediatric eye tumor in which bi-allelic inactivation of the 1 ( RB1 ) gene initiating genetic lesion. Although recently curative rates retinoblastoma have increased, there are at this time no molecular targeted therapies available. This is, part, due to lack highly penetrant and rapid animal models that facilitate identification targets allow therapeutic intervention. Different mouse available, all based on deactivation both Rb1 Retinoblastoma-like Rbl1 ), each...
Background: Arrhythmogenic Cardiomyopathy (ACM) is one of the major causes sudden cardiac death in young adults. With underlying patho-mechanisms not well understood, current therapeutic approaches for this genetic disease are solely symptomatic. A recent study demonstrates that loss cell-cell adhesion an important initial step leading to ACM. Because considered a key step, we aim identify new compounds from drug library, which can restore intercellular and potentially serve as therapeutics...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease characterized by progressive myocardial fibro-fatty replacement, arrhythmias and risk of sudden death. Its diagnosis challenging often it achieved after onset or postmortem. In this study, we sought to identify circulating microRNAs (miRNAs) differentially expressed in ARVC patients compared healthy controls. the pilot screened expression 754 miRNAs from 21 20 After filtering considering log fold-change...
ABSTRACT Terminally differentiated cardiomyocytes exhibit hypertrophy as a default response to injury by translating biomechanical stress into complex network of intracellular signaling events. The molecular intricacies how calcium-dependent engage circuits and epigenetic modifications activate deleterious gene programs remain enigmatic. Here we report on the re-activation evolutionarily conserved lncRNA “ Bigheart ”, which is repressed in postnatal myocardium quickly re-activated...