A5088469176- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Cardiac Arrest and Resuscitation
- Posttraumatic Stress Disorder Research
- Child Abuse and Trauma
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Menopause: Health Impacts and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Intimate Partner and Family Violence
- Trauma and Emergency Care Studies
- Spinal Cord Injury Research
- Balance, Gait, and Falls Prevention
- Advanced NMR Techniques and Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Injury Epidemiology and Prevention
- Long-Term Effects of COVID-19
- Sexual function and dysfunction studies
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Neuroendocrine regulation and behavior
- Disaster Response and Management
- COVID-19 and Mental Health
- Health, psychology, and well-being
- Cardiovascular Effects of Exercise
Ludwig-Maximilians-Universität München
2022-2025
Mass General Brigham
2025
Brigham and Women's Hospital
2022-2024
Harvard University
2022-2024
LMU Klinikum
2023
Leiden University
2017
Background The QOLIBRI-KID/ADO-Proxy is the first disease-specific health-related quality of life (HRQoL) proxy questionnaire developed for use in field pediatric traumatic brain injury (TBI), when children are unable to report their HRQoL themselves.
Background: The Balance Error Scoring System (BESS) is a commonly used method for clinically evaluating balance after traumatic brain injury. utilization of force plates, characterized by their cost-effectiveness and portability, facilitates the integration instrumentation into BESS protocol. Despite enhanced precision associated with instrumented measures, there remains need to determine clinical significance feasibility such measures within pediatric cohorts. Objective: To report...
Abstract Irregular menstrual cycles, affecting approximately 30% of women in their reproductive years, are often overlooked research, limiting our insights into the broader spectrum hormonal interactions. Understanding relationship between endogenous hormone fluctuations and brain function across cycle, particularly beyond regular is essential for comprehending mental disorders prevalent women. To this aim, a healthy female with an irregular cycle underwent dense sampling 5 consecutive...
Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). PTSD mTBI have been linked to alterations in white matter (WM) microstructure, but whether poor sleep quality has a compounding effect on WM remains largely unknown. We evaluated diffusion magnetic resonance imaging (dMRI) data from 180 male post-9/11 veterans diagnosed (1) (n = 38), (2) 25), (3) comorbid PTSD+mTBI 94), (4) control group neither nor 23). compared...
Health-related quality of life (HRQOL) is an important indicator for recovery after pediatric TBI. To date, there are a few questionnaires available assessing generic HRQOL in children and adolescents, but not yet any TBI-specific measures that applicable to populations. The aim the present study was examine psychometric characteristics newly developed Quality Life After Brain Injury Scale Kids Adolescents (QOLIBRI-KID/ADO) questionnaire capturing adolescents using item response theory (IRT)...
Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are common in Veterans linked to behavioral disturbances, increased risk of cognitive decline, Alzheimer's disease.We studied the synergistic effects PTSD TBI on behavioral, cognitive, neuroimaging measures Vietnam war Veterans.Data were acquired at baseline after about one-year from male categorized into: PTSD, TBI, PTSD+TBI, Veteran controls without or TBI. We applied manual tractography examine white matter...
Military service members are at increased risk for mental health issues, and comorbidity with mild traumatic brain injury (mTBI) is common. Largely overlapping symptoms between conditions suggest a shared pathophysiology. The present work investigates the associations among white matter microstructure, psychological functioning, serum neuroactive steroids that part of stress-response system. Diffusion-weighted imaging was acquired from 163 participants (with without military affiliation)...
The Rivermead Post-Concussion Symptoms Questionnaire (RPQ) assesses post-concussion symptoms (PCS) after traumatic brain injury (TBI). current study examines the applicability of self-report and proxy versions German RPQ in adolescents (13-17 years) TBI. We investigated reliability validity on total scale score level. Construct was by correlations with Inventory (PCSI-SR13), Generalized Anxiety Disorder Scale 7 (GAD-7), Patient Health 9 (PHQ-9) hypothesis testing regarding individuals'...
The gray matter/white matter (GM/WM) boundary of the brain is vulnerable to shear strain associated with mild traumatic injury (mTBI). It is, however, unknown whether GM/WM microstructure long-term outcomes following mTBI. diffusion and structural MRI data 278 participants between 18 65 years age without military background from Department Defense INTRuST study were analyzed. Fractional anisotropy (FA) was extracted at across for each lobe. Additionally, two conventional analytic approaches...
In the field of pediatric traumatic brain injury (TBI), relationships between pre-injury and injury-related characteristics post-TBI outcomes (functional recovery, post-concussion depression, anxiety) their impact on disease-specific health-related quality life (HRQoL) are under-investigated. Here, a multidimensional conceptual model was tested using structural equation (SEM). The final SEM evaluates associations these four latent variables. We retrospectively investigated 152 children (8-12...
Importance Military service members returning from theaters of war are at increased risk for mental illness, but despite high prevalence and substantial individual societal burden, the underlying pathomechanisms remain largely unknown. Exposure to levels emotional stress in mild traumatic brain injury (mTBI) presumed factors associated with development disorders. Objective To investigate (1) whether zone–related is microstructural alterations limbic gray matter (GM) independent disorders...
Background Intimate partner violence (IPV) perpetration is highly prevalent among veterans. Suggested risk factors of IPV include combat exposure, post-traumatic stress disorder (PTSD), depression, alcohol use, and mild traumatic brain injury (mTBI). While the underlying pathophysiological characteristics associated with remain largely unknown, previous studies have linked aggression to alterations limbic system. Here, we investigate whether microstructural abnormalities in military Further,...
Abstract Background The menstrual cycle is a critical indicator of women's reproductive, physical, and mental health, influenced by neuromodulatory sex steroid hormones, including estrogens like 17β-estradiol, estrone. Irregular cycles can lead to various health conditions. Understanding the relationship between endogenous hormone fluctuations brain function across essential for comprehending disorders prevalent in women. Here, we investigated impact hormonal variations on hippocampal...
Abstract Gonadal hormone fluctuations in females have been associated with symptoms of mental health, yet the underlying brain mechanisms remain understudied. Recent advances neuroscience shifted paradigm towards longitudinal tracking, enabling detection subtle changes overlooked conventional cross-sectional analyses. This dense-sampling approach acknowledges rhythmic nature gonadal production. Our study employed three densely sampled who underwent imaging and venipuncture (5 to 7 days per...