The brain is an endocrine organ, sensitive to the rhythmic changes in sex hormone production that occurs most mammalian species. In rodents and nonhuman primates, estrogen progesterone's impact on evident across a range of spatiotemporal scales. Yet, influence hormones functional architecture human largely unknown. this dense-sampling, deep phenotyping study, we examine extent which endogenous fluctuations alter intrinsic networks at rest woman who underwent imaging venipuncture for 30...

Abstract Pregnancy is a period of profound hormonal and physiological changes experienced by millions women annually, yet the neural unfolding in maternal brain throughout gestation are not well studied humans. Leveraging precision imaging, we mapped neuroanatomical an individual from preconception through 2 years postpartum. Pronounced decreases gray matter volume cortical thickness were evident across brain, standing contrast to increases white microstructural integrity, ventricle...

The rhythmic production of sex steroid hormones is a central feature the mammalian endocrine system. In rodents and nonhuman primates, are powerful regulators hippocampal subfield morphology. However, it remains unknown whether intrinsic fluctuations in alter morphology human brain. series dense-sampling studies, we used high-resolution imaging medial temporal lobe (MTL) to determine endogenous (Study 1) exogenous manipulation 2) MTL volume over time. Across menstrual cycle, progesterone...

A major challenge in neuroscience is to understand what happens a brain as it ages. Such insights could make possible distinguish between individuals who will undergo typical aging and those at risk for neurodegenerative disease. Over the last quarter century, thousands of human imaging studies have probed neural basis age-related cognitive decline. "Aging" generally enroll adults over age 65, historical precedent rooted average retirement U.S. wage-earners. consequence this research...

Sex steroid hormones have been shown to alter regional brain activity, but the extent which they modulate connectivity within and between large-scale functional networks over time has yet be characterized. Here, we applied dynamic community detection techniques data from a highly sampled female with 30 consecutive days of imaging venipuncture measurements characterize changes in resting-state structure across menstrual cycle. Four stable communities were identified, consisting nodes visual,...

Pregnancy is a period of profound hormonal and physiological change experienced by millions women annually, yet the neural changes unfolding in maternal brain throughout gestation have not been studied humans. Leveraging precision imaging, we mapped neuroanatomical an individual from preconception through two years postpartum. Pronounced decreases gray matter volume cortical thickness were evident across brain, which stand contrast to increases white microstructural integrity, ventricle...

Circadian, infradian, and seasonal changes in steroid hormone secretion have been tied to brain volume several mammalian species. However, the relationship between circadian production rhythmic morphology humans is largely unknown. Here, we examined diurnal fluctuations hormones multiscale a precision imaging study of male who completed forty MRI serological assessments at 7 A.M. 8 P.M. over course month, targeting concentrations their peak nadir. Diurnal were pronounced global regional...

In rodents and nonhuman primates, sex hormones are powerful modulators of dopamine (DA) neurotransmission. Yet less is known about hormonal regulation the DA system in human brain. Using positron emission tomography (PET), we address this gap by comparing contraceptive users nonusers across multiple aspects function: synthesis capacity via PET radioligand 6-[18F]fluoro-m-tyrosine ([18F]FMT), baseline D2/3 receptor binding potential using [11C]raclopride, release methylphenidate-paired...

Abstract Circadian, infradian, and seasonal changes in steroid hormone secretion have been tied to brain volume several mammalian species. However, the relationship between circadian production rhythmic morphology humans is largely unknown. Here, we examined diurnal fluctuations hormones multiscale a precision imaging study of male who completed forty MRI serological assessments at 7 A.M. 8 P.M. over course month, targeting concentrations their peak nadir. Diurnal were pronounced global...

Abstract Irregular menstrual cycles, affecting approximately 30% of women in their reproductive years, are often overlooked research, limiting our insights into the broader spectrum hormonal interactions. Understanding relationship between endogenous hormone fluctuations and brain function across cycle, particularly beyond regular is essential for comprehending mental disorders prevalent women. To this aim, a healthy female with an irregular cycle underwent dense sampling 5 consecutive...

Abstract The brain is an endocrine organ, sensitive to the rhythmic changes in sex hormone production that occurs most mammalian species. In rodents and nonhuman primates, estrogen progesterone’s impact on evident across a range of spatiotemporal scales. Yet, influence hormones functional architecture human largely unknown. this dense-sampling, deep phenotyping study, we examine extent which endogenous fluctuations alter intrinsic networks at rest woman who underwent imaging venipuncture for...

Abstract Sex steroid hormones have been shown to alter regional brain activity, but the extent which they modulate connectivity within and between large-scale functional networks over time has yet be characterized. Here, we applied dynamic community detection techniques data from a highly sampled female with 30 consecutive days of imaging venipuncture measurements characterize changes in resting-state structure across menstrual cycle. Four stable communities were identified consisting nodes...

Abstract Neuroendocrinology has received little attention in human neuroscience research, resulting a dearth of knowledge surrounding potent and dynamic modulators cognition behavior, as well brain structure function. This work addresses one such phenomenon by studying functional connectomics related to ovarian hormone fluctuations throughout the adult menstrual cycle. To do so, we used magnetic resonance imaging (fMRI) assessments from two dense, longitudinal datasets assess variations...

Abstract In rodents and nonhuman primates, sex hormones are powerful modulators of dopamine neurotransmission. Yet little is known about hormonal regulation the system in human brain. Using Positron Emission Tomography (PET), we address this gap by comparing contraceptive users non-users across multiple aspects function: synthesis capacity via PET radioligand 6-[ 18 F]fluoro-m-tyrosine ([ F]FMT), baseline D2/3 receptor binding potential using [ 11 C]raclopride, release methylphenidate-paired...

Abstract The rhythmic production of sex steroid hormones is a central feature the mammalian endocrine system. In rodents and nonhuman primates, are powerful regulators hippocampal subfield morphology. However, it remains unknown whether intrinsic fluctuations in alter morphology human brain. series dense-sampling studies, we used high-resolution imaging medial temporal lobe (MTL) to determine endogenous (Study 1) exogenous manipulation 2) MTL volume over time. Across menstrual cycle,...

Abstract Background The menstrual cycle is a critical indicator of women's reproductive, physical, and mental health, influenced by neuromodulatory sex steroid hormones, including estrogens like 17β-estradiol, estrone. Irregular cycles can lead to various health conditions. Understanding the relationship between endogenous hormone fluctuations brain function across essential for comprehending disorders prevalent in women. Here, we investigated impact hormonal variations on hippocampal...

Women are at higher risk of Alzheimer's and other neurological diseases after menopause, yet research connecting female brain health to sex hormone fluctuations is limited. We seek investigate this connection by developing tools that quantify 3D shape changes occur in the during fluctuations. Geodesic regression on space discrete surfaces offers a principled way characterize evolution brain's shape. However, its current form, approach too computationally expensive for practical use. In...

Women are at higher risk of Alzheimer's and other neurological diseases after menopause, yet research connecting female brain health to sex hormone fluctuations is limited. We seek investigate this connection by developing tools that quantify 3D shape changes occur in the during fluctuations. Geodesic regression on space discrete surfaces offers a principled way characterize evolution brain's shape. However, its current form, approach too computationally expensive for practical use. In...

Abstract In rodents and nonhuman primates, sex hormones are powerful modulators of dopamine neurotransmission. Yet little is known about hormonal regulation the system in human brain. Using Positron Emission Tomography (PET), we address this gap by comparing contraceptive users non-users across multiple aspects function: synthesis capacity via PET radioligand 6-[18F]fluoro-m-tyrosine ([18F]FMT), baseline D2/3 receptor binding potential using [11C]raclopride, release methylphenidate-paired...