A5101941014- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Reproduction
- Microtubule and mitosis dynamics
- Artificial Intelligence in Healthcare
- Genetic and Kidney Cyst Diseases
- Hip and Femur Fractures
- Pelvic and Acetabular Injuries
- Photosynthetic Processes and Mechanisms
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Advanced Memory and Neural Computing
- Artificial Intelligence in Healthcare and Education
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Orthopaedic implants and arthroplasty
- Protist diversity and phylogeny
- Explainable Artificial Intelligence (XAI)
- Olfactory and Sensory Function Studies
- Ethics and Social Impacts of AI
- Ethics in Clinical Research
- Climate change impacts on agriculture
- Human-Automation Interaction and Safety
- Older Adults Driving Studies
- Cardiovascular Health and Risk Factors
University of Arkansas for Medical Sciences
2022-2024
Johns Hopkins University Applied Physics Laboratory
2019-2024
University of Arkansas at Fayetteville
2023
Allen Institute for Artificial Intelligence
2023
United States Department of Veterans Affairs
2023
University of California, Santa Barbara
2019-2022
University of Minnesota
2004-2013
The Wistar Institute
2013
North Carolina State University
2003
The nexin-dynein regulatory complex (N-DRC) is proposed to coordinate dynein arm activity and interconnect doublet microtubules. Here we identify a conserved region in DRC4 critical for assembly of the N-DRC into axoneme. At least 10 subunits associate with form discrete distinct from other axonemal substructures. Transformation drc4 mutants epitope-tagged rescues motility defects restores missing DRC associated inner-arm dyneins. Four new contain calcium-signaling motifs and/or AAA domains...
Intraflagellar transport (IFT) is a bidirectional process required for assembly and maintenance of cilia flagella. Kinesin-2 the anterograde IFT motor, Dhc1b/Dhc2 drives retrograde IFT. To understand how either motor interacts with particle or their activities might be coordinated, we characterized ts mutation in Chlamydomonas gene encoding KAP, nonmotor subunit Kinesin-2. The fla3-1 an amino acid substitution conserved C-terminal domain. strains assemble flagella at 21 degrees C, but cannot...
Sex steroid hormones have been shown to alter regional brain activity, but the extent which they modulate connectivity within and between large-scale functional networks over time has yet be characterized. Here, we applied dynamic community detection techniques data from a highly sampled female with 30 consecutive days of imaging venipuncture measurements characterize changes in resting-state structure across menstrual cycle. Four stable communities were identified, consisting nodes visual,...
Increased phosphorylation of dynein IC IC138 correlates with decreases in flagellar microtubule sliding and phototaxis defects. To test the hypothesis that regulation controls bending, we cloned gene. encodes a novel protein calculated mass 111 kDa is predicted to form seven WD-repeats at C terminus. maps near BOP5 locus, bop5-1 contains point mutation resulting truncated lacking terminus, including seventh WD-repeat. cells display wild-type beat frequency but swim slower than cells,...
The chromatin regulatory factors CTCF and cohesin have been implicated in the coordinated control of multiple gene loci Epstein-Barr virus (EBV) latency. We found that are highly enriched at convergent partially overlapping transcripts for LMP1 LMP2A genes, but it is not yet known how may coordinately regulate these transcripts. now show genetic disruption this binding site (EBVΔCTCF166) leads to a deregulation LMP1, LMP2A, LMP2B transcription EBV-immortalized B lymphocytes. EBVΔCTCF166...
Mathematical modeling of behavioral sequences yields insight into the rules and mechanisms underlying sequence generation. Grooming in Drosophila melanogaster is characterized by repeated execution distinct, stereotyped actions variable order. Experiments demonstrate that, following stimulation an irritant, grooming progresses gradually from early phase dominated anterior cleaning to a later with increased walking posterior cleaning. We also observe at intermediate temporal scale, there...
To understand the mechanisms that regulate assembly and activity of flagellar dyneins, we focused on I1 inner arm dynein (dynein f) a null allele, bop5-2, defective in gene encoding IC138 phosphoprotein subunit. assembles bop5-2 axonemes but lacks at least four subunits: IC138, IC97, LC7b, flagellar-associated protein (FAP) 120—defining new subcomplex. Electron microscopy image averaging revealed defect base dynein, between radial spoke 1 outer arms. Microtubule sliding velocities also are...
Behavioral differences can be observed between species or populations (variation) individuals in a genetically similar population (variability). Here, we investigate genetic as possible source of variation and variability Drosophila grooming. Grooming confers survival social benefits. features five exposed to dust irritant were analyzed. Aspects grooming behavior, such anterior posterior progression, conserved within species. However, significant activity levels, proportion time spent...
Introduction The rapid expansion of artificial intelligence (AI) has produced many opportunities, but also new risks that must be actively managed, particularly in the health care sector with clinical practice to avoid unintended health, economic, and social consequences. Methods Given much research development (R&D) involving human subjects is reviewed rigorously monitored by institutional review boards (IRBs), we argue supplemental questions added IRB process an efficient risk...
Motor vehicle crashes are a leading cause of death in the United States, and disproportionately impact communities color. Replacing human control with automated vehicles (AVs) holds potential to reduce save lives. The benefits AVs, including shuttles, buses, or cars could extend beyond safety include improvements congestion, reductions emissions, increased access mobility, particularly for vulnerable populations. However, AVs have not attained level public trust that has been expected, given...
In retina pigmentosa and macular degeneration, the photoreceptor cells of (rods cones) fail to respond light. However, discovery that direct electrical stimulation retinal neurons can create visual sensation in patients inspires an electronic prosthesis which bypasses defective photoreceptors. A prosthetic system is conceptually illustrated. prototype implantable power data receiver neural stimulator, 4.6/spl times/4.7 mm/sup 2/ 1.2 /spl mu/m CMOS, drive a 10/spl times/10 array electrodes at...
In certain diseases of the retina, photoreceptor cells do not respond to light and thus cause blindness. We describe an electronic retinal prosthesis system that can provide some vision patients by direct electrical stimulation neurons. Power image data are transferred implanted stimulator through a wireless inductive link. The consists external video camera with processing encoding hardware power transmitter. Implanted in eye receivers, stimulus circuits, electrode array. most recent...
Each passing day seems to bring new instances of automation routine tasks and the addition artificial intelligence or machine learning algorithms domains. Autonomous systems are a diverse class technologies ranging from AI driven natural language processing image recognition closed-form control for aircraft autopiloting. Coincident with this explosion in autonomy is related drumbeat stories failures. These failures have ranged tragedies resulting bystander deaths humorous examples video game...
Abstract Sex steroid hormones have been shown to alter regional brain activity, but the extent which they modulate connectivity within and between large-scale functional networks over time has yet be characterized. Here, we applied dynamic community detection techniques data from a highly sampled female with 30 consecutive days of imaging venipuncture measurements characterize changes in resting-state structure across menstrual cycle. Four stable communities were identified consisting nodes...
The increasing capabilities of AI pose new risks and vulnerabilities for organizations decision makers. Several trustworthy frameworks have been created by U.S. federal agencies international to outline the principles which systems must adhere their use be considered responsible. Different reflect priorities perspectives different stakeholders, there is no consensus on a single framework yet. We evaluate leading provide holistic perspective values, allowing create agency-specific strategies...
Background: Critically ill patients frequently experience multi-organ dysfunction and unstable vital signs, increasing their risk of myocardial injury elevated serum troponin levels. Myocardial from oxygen supply-demand mismatch, whether due to systemic disease or obstructive coronary artery (CAD), often leads undergoing an invasive angiogram (ICA) potentially percutaneous intervention (PCI) if CAD is identified. However, this procedure carries significant risks for critically patients. To...
The generalized Lotka-Volterra (gLV) equations are a mathematical proxy for ecological dynamics. We focus on gLV model of the gut microbiome, in which evolution microbial state is determined part by pairwise inter-species interaction parameters that encode environmentally-mediated resource competition between microbes. develop an silico method controls steady-state outcome system adjusting these parameters. This approach confined to bistable region model. two steady states interest idealized...
Behavioral differences can be observed between species or populations (variation) individuals in a genetically similar population (variability). Here, we investigate genetic as possible source of variation and variability Drosophila grooming. Grooming confers survival social benefits. features five exposed to dust irritant were analyzed. Aspects grooming behavior, such anterior posterior progression, conserved within species. However, significant activity levels, proportion time spent...
Background: The first reported COVID-19 case in Arkansas was on 11 March 2020, two months after the United States. We sought to analyze rates of respiratory illness and influenza tests during 2019/2020 season compared pre-pandemic years assess whether there were higher than expected, which may suggest undiagnosed cases. Methods: Using data collected from warehouse largest hospital Arkansas, ICD-9 ICD-10 codes related identified for 1 October May 2017–2020. Results: 25,747 patients admitted...
Background: Cardiac resynchronization therapy (CRT) plays an important role in managing patients with advanced heart failure (HF) reduced ejection fraction and interventricular conduction block, as it reestablishes synchrony cardiac function while reducing the risks of HF-related hospitalizations mortality. Despite well-described advantages CRT, approximately 30% to 40% fail respond therapy. Therefore, our study aimed define patient characteristics associated major adverse events (MACE)...