A5070330894- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Posttraumatic Stress Disorder Research
- Resilience and Mental Health
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Infant Development and Preterm Care
- Child and Adolescent Psychosocial and Emotional Development
- Infrared Thermography in Medicine
- Olfactory and Sensory Function Studies
- Childhood Cancer Survivors' Quality of Life
- Mental Health Treatment and Access
- Fire effects on ecosystems
Universitätsmedizin Göttingen
2021-2024
University of Göttingen
2021-2023
Max Planck Institute of Experimental Medicine
2018-2019
Patients with mild traumatic brain injury (mTBI) are at risk for post-concussion (PC) symptoms and post-traumatic stress disorder (PTSD). The co-occurrence of PC PTSD after mTBI in relation to health-related quality life (HRQoL), health care utilization, return work has not yet been investigated. were measured six months post-TBI by respectively the Rivermead Post-Concussion Symptoms Questionnaire (RPQ) Post-Traumatic Stress Disorder Checklist DSM-5 (PCL-5). Of 1566 individuals who met...
Traumatic brain injury (TBI) remains one of the leading causes death and disability worldwide. To better understand its impact on various outcome domains, this study pursues following: (1) longitudinal assessments at three, six, twelve months post-injury; (2) an evaluation sociodemographic, premorbid, injury-related factors, functional recovery contributing to worsening or improving outcomes after TBI. Using patient-reported measures, recuperation trends TBI were identified by applying...
Assessing outcomes in multinational studies on traumatic brain injury (TBI) poses major challenges and requires relevant instruments languages other than English. Of the 19 outcome selected for use observational Collaborative European NeuroTrauma Effectiveness Research TBI (CENTER-TBI) study, 17 measures lacked translations at least one target language. To fill this gap, we aimed to develop well-translated linguistically psychometrically validated instruments. We performed linguistic...
Traumatic brain injury (TBI) may lead to impairments in various outcome domains. Since most instruments assessing these are only available a limited number of languages, psychometrically validated translations important for research and clinical practice. Thus, our aim was investigate the psychometric properties patient-reported measures (PROM) applied CENTER-TBI study. The study sample comprised individuals who filled six-months assessments (GAD-7, PHQ-9, PCL-5, RPQ, QOLIBRI/-OS,...
Early exposure to negative environmental impact shapes individual behavior and potentially contributes any mental disease. We reported previously that accumulated risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed high-risk subjects had >5 times greater probability forensic hospitalization. In line with longstanding sociological theories, we hypothesized accumulation before adulthood induces violent...
After traumatic brain injury (TBI), individuals may experience short- or long-term health burdens, often referred to as post-concussion symptoms (PCS). The Rivermead Post-Concussion Symptoms Questionnaire (RPQ) is one of the commonly used instruments assess self-reported PCS. To date, no reference values for RPQ have been provided, although they are crucial clinical practice when evaluating a patient's status relative comparable healthy population. Therefore, aim this study provide United...
Traumatic brain injury (TBI) can negatively impact patients’ lives on many dimensions. Multiple instruments are available for evaluating TBI outcomes, but it is still unclear which the most sensitive that purpose. This study examines sensitivity of nine outcome in terms their ability to discriminate within and between specific patient groups, selected a priori as identified from literature, at three different time points year after (i.e., 3, 6, 12 months post injury). The sociodemographic...
Abstract Background Comparison of patient-reported outcomes in multilingual studies requires evidence the equivalence translated versions questionnaires. The present study examines factorial validity and comparability six language Rivermead Post-Concussion Symptoms Questionnaire (RPQ) administered to individuals following traumatic brain injury (TBI) Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. Methods Six competing RPQ models were estimated using data from...
Health-related quality of life (HRQOL) is an important indicator for recovery after pediatric TBI. To date, there are a few questionnaires available assessing generic HRQOL in children and adolescents, but not yet any TBI-specific measures that applicable to populations. The aim the present study was examine psychometric characteristics newly developed Quality Life After Brain Injury Scale Kids Adolescents (QOLIBRI-KID/ADO) questionnaire capturing adolescents using item response theory (IRT)...
Traumatic brain injury (TBI) is frequently associated with neuropsychiatric impairments such as symptoms of post-traumatic stress disorder (PTSD), which can be screened using self-report instruments the Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5). The current study aims to inspect factorial validity and cross-linguistic equivalence PCL-5 in individuals after TBI differential severity. Data six language groups (n ≥ 200; Dutch, English, Finnish, Italian, Norwegian, Spanish) were...
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The Rivermead Post-Concussion Symptoms Questionnaire (RPQ) assesses post-concussion symptoms (PCS) after traumatic brain injury (TBI). current study examines the applicability of self-report and proxy versions German RPQ in adolescents (13-17 years) TBI. We investigated reliability validity on total scale score level. Construct was by correlations with Inventory (PCSI-SR13), Generalized Anxiety Disorder Scale 7 (GAD-7), Patient Health 9 (PHQ-9) hypothesis testing regarding individuals'...
Psychopathological symptoms are common sequelae after traumatic brain injury (TBI), leading to increased personal and societal burden. Previous studies on factors influencing Post-traumatic Stress Disorder (PTSD), Generalized Anxiety (GAD), Major Depressive (MDD) TBI have produced inconclusive results, partly due methodological limitations. The current study investigated the influence of commonly proposed clinical impairment, occurrence, frequency, intensity PTSD, GAD, MDD TBI. sample...
In the field of pediatric traumatic brain injury (TBI), relationships between pre-injury and injury-related characteristics post-TBI outcomes (functional recovery, post-concussion depression, anxiety) their impact on disease-specific health-related quality life (HRQoL) are under-investigated. Here, a multidimensional conceptual model was tested using structural equation (SEM). The final SEM evaluates associations these four latent variables. We retrospectively investigated 152 children (8-12...
Abstract Background Comparison of patient-reported outcomes in multilingual studies requires evidence the equivalence translated versions questionnaires. The present study examines comparability six language Rivermead Post-Concussion Symptoms Questionnaire (RPQ) administered to individuals following traumatic brain injury (TBI) Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. Methods Six competing RPQ models were fitted data from Dutch (n = 597), English 223),...
Abstract Background The German Rivermead Post-Concussion Symptoms Questionnaire (RPQ) can be used to assess post-concussion symptoms (PCS) after traumatic brain injury (TBI) in adults, adolescents, and children. Methods In this study, we examined the psychometric properties of RPQ proxy version ( N = 146) for children (8—12 years) TBI at item, total scale score level. Construct validity was analyzed using rank correlations with proxy-assessed Inventory (PCSI-P), Patient Health 9 (PHQ-9),...
<title>Abstract</title> To date, there are no age-appropriate instruments for assessing the subjective impact of pediatric traumatic brain injury (TBI) sequelae on multiple domains health-related quality life (HRQoL) in young children. The present study therefore aims to develop and examine psychometric properties a new disease-specific HRQoL instrument, Quality Life after Brain Injury children aged 6–7 years (QOLIBRI-KIDDY). Questionnaire development included focus group interviews,...
The Quality of Life after Brain Injury (QoLIBRI) questionnaire was developed and validated to assess disease-specific health-related quality life (HRQoL) in individuals TBI. present study aims determine its longitudinal validity by assessing responsiveness response shift from 3 6 months post-injury. Analyses were based on data the European observational cohort Collaborative NeuroTrauma Effectiveness Research Traumatic study. A total 1659 recovering TBI included analyses. Response assessed...
Abstract Background Comparison of patient-reported outcomes in multilingual studies requires evidence the equivalence translated versions questionnaires. The present study examines factorial validity and comparability six language Rivermead Post-Concussion Symptoms Questionnaire (RPQ) administered to individuals following traumatic brain injury (TBI) Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. Methods Six competing RPQ models were estimated using data from...
<title>Abstract</title> <bold>Background. </bold>The German Rivermead Post-Concussion Symptoms Questionnaire (RPQ) can be used to assess post-concussion symptoms (PCS) after traumatic brain injury (TBI) in adults, adolescents, and children. <bold>Methods.</bold> In this study, we examined the psychometric properties of RPQ proxy version (N = 146) for children (8—12 years) TBI on item, total scale score level. Construct validity was analyzed using rank correlations with proxy-assessed...