A5050543841- Dermatologic Treatments and Research
- Facial Rejuvenation and Surgery Techniques
- Autophagy in Disease and Therapy
- Hair Growth and Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Heparin-Induced Thrombocytopenia and Thrombosis
- Laser Applications in Dentistry and Medicine
- Infectious Diseases and Mycology
- Body Contouring and Surgery
- Body Image and Dysmorphia Studies
- Platelet Disorders and Treatments
- 14-3-3 protein interactions
- Tryptophan and brain disorders
- Ubiquitin and proteasome pathways
- Cancer Risks and Factors
- Autoimmune Bullous Skin Diseases
- PI3K/AKT/mTOR signaling in cancer
- Inflammatory Myopathies and Dermatomyositis
- Infection Control in Healthcare
- Urticaria and Related Conditions
- PARP inhibition in cancer therapy
- Celiac Disease Research and Management
- T-cell and B-cell Immunology
- Dermatological and COVID-19 studies
- Cutaneous Melanoma Detection and Management
Union Theological Seminary
2024
Dermatology Surgery & Laser Center
2018-2020
Boston University
2015-2017
National Institutes of Health
2008-2017
National Institute on Aging
2008-2017
Boston Medical Center
2017
American Academy of Dermatology
2016
Philadelphia University
2014
California University of Pennsylvania
2014
Palmetto Hematology Oncology
2014
Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective this trial was to determine maximum tolerated dose (MTD) and HCQ in combination radiation therapy (RT) temozolomide (TMZ) for newly diagnosed glioblastoma (GB). A 3 + phase I design followed by a noncomparative II study conducted GB patients after initial resection. Patients received (200 800 mg oral daily) RT concurrent adjuvant TMZ....
The combination of temsirolimus (TEM), an MTOR inhibitor, and hydroxychloroquine (HCQ), autophagy augments cell death in preclinical models. This phase 1 dose-escalation study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, pharmacodynamics HCQ with TEM cancer patients. In escalation portion, 27 patients advanced solid malignancies were enrolled, followed by a cohort expansion at top level 12 metastatic melanoma. was well tolerated, grade 3 or 4...
The efficacy of proteasome inhibition for myeloma is limited by therapeutic resistance, which may be mediated activation the autophagy pathway as an alternative mechanism protein degradation. Preclinical studies demonstrate that with hydroxychloroquine augments antimyeloma inhibitor bortezomib. We conducted a phase I trial combining bortezomib and relapsed or refractory myeloma. enrolled 25 patients, including 11 (44%) to prior No protocol-defined dose-limiting toxicities occurred, we...
Blocking autophagy with hydroxychloroquine (HCQ) augments cell death associated alkylating chemotherapy in preclinical models. This phase I study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmacokinetics, and pharmacodynamics of HCQ combination dose-intense temozolomide (TMZ) patients advanced solid malignancies. Forty (73% metastatic melanoma) were treated oral 200 to 1200 mg daily TMZ 150 mg/m2 for 7/14 d. was well no recurrent dose-limiting toxicities...
Abstract Background Chronic N -Methyl-D-aspartate (NMDA) administration to rats is reported increase arachidonic acid signaling and upregulate neuroinflammatory markers in rat brain. These changes may damage brain cells. In this study, we determined if chronic NMDA (25 mg/kg i.p., 21 days) would alter expression of pro- anti-apoptotic factors frontal cortex, compared with vehicle control. Results Using real time RT-PCR Western blotting, was shown decrease mRNA protein levels Bcl-2 BDNF,...
Journal Article The Relationship of Menopausal Hot Flushes to Medical and Reproductive Experience Get access Barry M. Sherman, MD, MD 2Dept. Preventive Medicine, Univ. Iowa College MedicineIowa City, IA 52242 Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert B. Wallace, 3Dept. Internal Judy A. Bean, PhD, PhD Yueh Chang, Chang Laurel Schlabaugh Gerontology, Volume 36, Issue 3, May 1981, Pages 306–309, https://doi.org/10.1093/geronj/36.3.306 Published: 01 1981
Purpose Microfocused ultrasound (MFUS) is a safe and effective method for noninvasive skin tightening. Previous clinical studies demonstrate 60–100% patient satisfaction after MFUS. We used an anonymous online platform MFUS to assess satisfaction. Design Patients treated with between January 2013 2016 were invited complete survey at least 4 months post‐treatment. asked rate improvement in tightening as none (0%), mild (0–25%), moderate (26–50%), significant (51–75%), or dramatic (76–100%)...
The pulsed dye laser (PDL) is used for the treatment of a variety vascular and nonvascular disorders, its therapeutic efficacy often depends on purpura as an endpoint. However, post-PDL undesirable side effect it may increase patient dissatisfaction downtime. Recent studies have suggested that repeat with PDL speed resolution post-procedural purpura; however, there paucity data using specifically purpura. We report three cases 585 nm PDL-induced treated 595 clinically significant...
Purpose : The purpose of this study was to evaluate the clinical effect Vitamin C, E, lysozyme, carbazochrome complex medicine(IGATAN(R)) for periodontal disease. Material and Methods performed by double blinded, ramdomized method. Forty two subjects diagnosed as chronic incipient or moderate periodontitis at department periodontology, Yonsei Dental Hospital were included in study. This approved Institutional Review Board, University Hospital. All received scaling their first examination...